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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Piperidines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines

Comprehensive Overview of (3-Propylpiperidin-3-yl)methanol (CAS No. 915925-19-8): Properties, Applications, and Research Insights

(3-Propylpiperidin-3-yl)methanol (CAS No. 915925-19-8) is a specialized organic compound gaining attention in pharmaceutical and chemical research due to its unique structural features. This piperidine derivative combines a propyl group with a hydroxymethyl substitution at the 3-position, offering versatile reactivity for synthetic applications. Researchers are particularly interested in its potential as a building block for drug discovery, given its ability to modulate biological activity through stereochemical control.

The compound's molecular structure (C9H19NO) features a heterocyclic piperidine ring, which is a common motif in bioactive molecules. Recent studies highlight its relevance in developing central nervous system (CNS) targeting compounds, aligning with current industry focus on neurological therapeutics. Its physicochemical properties—including moderate polarity (logP ~1.8) and water solubility—make it suitable for various formulation approaches, addressing the growing demand for bioavailable small molecules in medicinal chemistry.

In synthetic chemistry, 915925-19-8 serves as a valuable intermediate for constructing chiral scaffolds. The presence of both the piperidine nitrogen and hydroxyl group allows for diverse derivatization pathways, meeting the pharmaceutical industry's need for structural diversity. Current trends in fragment-based drug design have increased interest in such compact, functionalized heterocycles that can serve as molecular fragments for lead optimization.

Analytical characterization of (3-Propylpiperidin-3-yl)methanol typically involves advanced techniques like HPLC-MS and NMR spectroscopy, reflecting the compound's importance in quality-controlled processes. The scientific community has shown particular interest in its stereoisomeric purity, as evidenced by recent publications exploring its resolution methods—a critical consideration for developing enantioselective synthesis routes in modern pharmaceutical manufacturing.

From a commercial perspective, the compound addresses several market needs in the life sciences sector. Its applications span medicinal chemistry, bioconjugation, and material science, making it relevant to current discussions about multipurpose chemical entities. Suppliers often highlight its stability under standard storage conditions (typically 2-8°C), which aligns with industry preferences for easy-to-handle intermediates in research workflows.

Emerging research directions explore the compound's potential in catalysis and asymmetric synthesis, particularly as a ligand precursor. These applications resonate with the growing emphasis on sustainable chemistry practices, where efficient molecular transformations reduce waste. The hydroxymethyl group's versatility enables participation in various bond-forming reactions, a feature frequently searched by synthetic chemists optimizing green chemistry protocols.

Quality specifications for CAS 915925-19-8 typically require ≥95% purity, with rigorous control of process-related impurities—a critical factor for researchers investigating structure-activity relationships. Recent patent analyses reveal its incorporation in several pharmacophore models, particularly for targets involving G-protein coupled receptors (GPCRs), demonstrating its relevance to contemporary drug discovery paradigms.

The compound's safety profile has been documented in standard chemical databases, with appropriate handling precautions for laboratory use. This information addresses frequent queries from EHS (Environment, Health, and Safety) professionals seeking risk assessment data for research chemicals. Its classification as non-hazardous under normal conditions makes it attractive for academic and industrial laboratories focused on benign chemical synthesis.

Future research directions may explore the metabolic stability of derivatives containing this scaffold, responding to the pharmaceutical industry's focus on ADME optimization. The compound's balanced lipophilicity profile positions it well for investigations into blood-brain barrier permeability—a hot topic in CNS drug development circles. Computational chemistry studies are increasingly examining its conformational preferences to inform rational drug design strategies.

From a supply chain perspective, (3-Propylpiperidin-3-yl)methanol is available through specialized fine chemical suppliers, with current market analysis indicating stable availability. Its pricing reflects the technical challenges associated with maintaining chiral integrity during synthesis—an important consideration for cost-sensitive research programs. The compound's shelf life and storage stability data are frequently requested parameters, underscoring its practical utility in long-term research projects.

• 73207-93-9(Piperidinium,3-(hydroxymethyl)-1,1-dimethyl-)
• 5176-22-7(Quinuclidin-3-ylmethanol)
• 205194-35-0((S)-(1-methylpiperidin-3-yl)methanol)
• 54525-19-8((1-Ethylpiperidin-3-yl)methanol)
• 221298-00-6((3-Methylpiperidin-3-yl)methanol)
• 88644-21-7([(3S)-1-azabicyclo[2.2.2]octan-3-yl]methanol)
• 7583-53-1((1-methylpiperidin-3-yl)methanol)
• 205194-11-2((R)-(1-methylpiperidin-3-yl)methanol)
• 230294-57-2(3-Piperidinemethanol,1-methyl-, (-)-)
• 62101-68-2(3-Methyl-2-piperidin-1-ylmethyl-butan-1-ol)