• 1. An air-stable organometallic polymer containing titanafluorene moieties obtained by the Sonogashira–Hagihara cross-coupling polycondensation?
  Alvin Tanudjaja,Shinsuke Inagi,Fusao Kitamura,Toshikazu Takata,Ikuyoshi Tomita Dalton Trans., 2021,50, 3037-3043
• 2. An integrated microfluidic platform for sensitive and rapid detection of biological toxins?
  Robert J. Meagher,Anson V. Hatch,Ronald F. Renzi,Anup K. Singh Lab Chip, 2008,8, 2046-2053
• 3. An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS?
  Hyejin Moon,Aaron R. Wheeler,Robin L. Garrell,Chang-Jin “CJ” Kim Lab Chip, 2006,6, 1213-1219
• 4. An Aptamer Bio-barCode (ABC) assay using SPR, RNase H, and probes with RNA and gold-nanorods for anti-cancer drug screening
  Chengbin Yang,Hing Lun Tsang,Pui Man Lau,Ken-Tye Yong,Ho Pui Ho,Siu Kai Kong Analyst, 2017,142, 3579-3587
• 5. An insight into the role of side chains in the microstructure and carrier mobility of high-performance conjugated polymers?
  Jianyao Huang,Dong Gao,Zhihui Chen,Weifeng Zhang Polym. Chem., 2021,12, 2471-2480

• Other Chemical Reagents Derivatization Reagents
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Comprehensive Overview of (3-Chloro-4-ethoxy-2-fluorophenyl)boronic acid (CAS No. 909122-50-5)

(3-Chloro-4-ethoxy-2-fluorophenyl)boronic acid (CAS No. 909122-50-5) is a highly versatile boronic acid derivative widely used in pharmaceutical research, organic synthesis, and material science. This compound belongs to the class of arylboronic acids, which are pivotal in Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern synthetic chemistry. With its unique chloro, ethoxy, and fluoro substitutions, this boronic acid offers exceptional reactivity and selectivity, making it a valuable building block for drug discovery and advanced material development.

The growing interest in 909122-50-5 is driven by its applications in targeted drug delivery systems and bioconjugation techniques. Researchers are increasingly exploring its potential in cancer therapeutics, particularly in the design of small-molecule inhibitors and proteolysis-targeting chimeras (PROTACs). The compound’s ability to form stable covalent bonds with diols and other functional groups also makes it a key player in sensor development and diagnostic assays.

In the context of green chemistry, (3-Chloro-4-ethoxy-2-fluorophenyl)boronic acid aligns with the demand for sustainable synthetic routes. Its role in metal-free catalysis and biocompatible reactions has garnered attention, especially as the pharmaceutical industry shifts toward environmentally friendly processes. Recent studies highlight its utility in flow chemistry setups, where its stability and solubility profile enhance reaction efficiency.

From a commercial perspective, the compound’s high purity grades (e.g., >98%) are critical for GMP-compliant manufacturing. Suppliers often emphasize its low toxicity profile and compatibility with aqueous conditions, addressing concerns about safety and scalability. These attributes make it a preferred choice for high-throughput screening and combinatorial chemistry applications.

Emerging trends in AI-driven drug discovery have further amplified the relevance of CAS No. 909122-50-5. Computational models frequently incorporate its structural features to predict bioactivity and ADMET properties. Additionally, its use in DNA-encoded libraries (DELs) underscores its role in next-generation screening platforms.

For researchers seeking custom synthesis or bulk quantities, it’s essential to evaluate supplier reliability and analytical documentation. The compound’s NMR and HPLC data are typically provided to ensure batch-to-batch consistency, a critical factor for reproducible results in academic and industrial settings.

In summary, (3-Chloro-4-ethoxy-2-fluorophenyl)boronic acid (CAS No. 909122-50-5) represents a convergence of innovation, sustainability, and practical utility in chemical research. Its multifaceted applications—from precision medicine to smart materials—position it as a compound of enduring significance in the scientific community.

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