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3-Cinnolinecarboxylic Acid, 4-Hydroxy-8-Methyl- (CAS No: 90771-19-0)

3-Cinnolinecarboxylic Acid, 4-Hydroxy-8-Methyl- is a biologically active compound with the CAS registry number 90771-19-0. This compound belongs to the class of cinnolinic acids, which are known for their diverse pharmacological properties. The molecule features a cinnoline ring system with a carboxylic acid group at position 3, a hydroxyl group at position 4, and a methyl substituent at position 8. These structural features contribute to its unique chemical and biological properties.

The synthesis of 3-Cinnolinecarboxylic Acid, 4-Hydroxy-8-Methyl- involves multi-step organic reactions, often utilizing cinnoline derivatives as starting materials. Recent advancements in synthetic chemistry have enabled the development of more efficient and scalable methods for its production. Researchers have explored various catalytic systems and reaction conditions to optimize the yield and purity of this compound.

One of the most significant areas of research on 3-Cinnolinecarboxylic Acid, 4-Hydroxy-8-Methyl- is its potential as a lead compound in drug discovery. Studies have shown that this compound exhibits antimicrobial activity, particularly against gram-positive bacteria and certain fungal strains. Its ability to inhibit bacterial growth without causing significant cytotoxicity to mammalian cells makes it a promising candidate for the development of new antibiotics.

Additionally, 3-Cinnolinecarboxylic Acid, 4-Hydroxy-8-Methyl- has been investigated for its anti-inflammatory properties. Preclinical studies suggest that it can modulate inflammatory pathways by inhibiting key enzymes such as cyclooxygenase (COX) and lipoxygenase (LOX). These findings highlight its potential application in treating inflammatory diseases such as arthritis and dermatitis.

The compound has also been studied for its anticancer activity. Research indicates that 3-Cinnolinecarboxylic Acid, 4-Hydroxy-8-Methyl- can induce apoptosis in cancer cells by targeting specific signaling pathways. Its ability to selectively target cancer cells while sparing normal cells underscores its potential as a chemotherapeutic agent.

In recent years, there has been growing interest in the use of 3-Cinnolinecarboxylic Acid, 4-Hydroxy-8-Methyl- as a neuroprotective agent. Studies have demonstrated that it can protect neurons from oxidative stress and inflammation, which are key contributors to neurodegenerative diseases such as Alzheimer's and Parkinson's disease.

The structural versatility of 3-Cinnolinecarboxylic Acid, 4-Hydroxy-8-Methyl-* enables further functionalization to enhance its bioavailability and efficacy. Researchers are exploring various strategies such as prodrug design and nanoparticle delivery systems to improve its pharmacokinetic properties.

In conclusion, 3-Cinnolinecarboxylic Acid, 4-Hydroxy-8-Methyl-* (CAS No: 90771-19-) is a multifaceted compound with significant potential in various therapeutic areas. Its unique chemical structure and diverse biological activities make it an intriguing subject for further research and development in the fields of medicinal chemistry and pharmacology.

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