• 1. Fast-Track to Research Data Management in Experimental Material Science-Setting the Ground for Research Group Level Materials Digitalization.
  LarsBanko,AlfredLudwig
• 2. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 3. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526
• 4. Evolution study of photo-synthesized gold nanoparticles by spectral deconvolution model: a quantitative approach
  Chung-Sung Yang,Mong-Shian Shih,Fang-Yi Chang New J. Chem., 2006,30, 729-735
• 5. Evidence of rutile-to-anatase photo-induced electron transfer in mixed-phase TiO2 by solid-state NMR spectroscopy?
  Weili Dai,Guangjun Wu,Michael Hunger Chem. Commun., 2015,51, 13779-13782

Recent Advances in the Application of Isodecyl Citrate (CAS 90605-17-7) in Chemical Biology and Pharmaceutical Research

Isodecyl Citrate (CAS 90605-17-7) has emerged as a compound of significant interest in the field of chemical biology and pharmaceutical research due to its versatile applications as a plasticizer, stabilizer, and potential bioactive agent. Recent studies have explored its physicochemical properties, biocompatibility, and therapeutic potential, positioning it as a promising candidate for various biomedical applications. This research brief synthesizes the latest findings on Isodecyl Citrate, focusing on its molecular characteristics, synthesis methods, and emerging roles in drug delivery and medical device development.

A 2023 study published in the Journal of Biomaterials Science investigated the use of Isodecyl Citrate as a plasticizer in polyvinyl chloride (PVC) medical devices. The research demonstrated that Isodecyl Citrate exhibits superior migration resistance and thermal stability compared to traditional phthalate-based plasticizers, addressing critical safety concerns in medical applications. The study employed accelerated aging tests and cytotoxicity assays, revealing that devices plasticized with Isodecyl Citrate maintained mechanical integrity while showing significantly reduced leaching (less than 0.5% after 30 days at 37°C) and excellent biocompatibility (cell viability >95% in L929 fibroblast assays).

In the realm of drug delivery, innovative research has explored Isodecyl Citrate's potential as a component in nanoparticle formulations. A 2024 paper in Advanced Drug Delivery Reviews highlighted its role in stabilizing lipid-based nanocarriers, where its amphiphilic nature contributes to enhanced drug loading capacity and controlled release kinetics. Particularly noteworthy was the compound's ability to improve the bioavailability of hydrophobic anticancer agents, with one formulation showing a 3.2-fold increase in tumor accumulation compared to conventional delivery systems in murine models.

The synthesis and characterization of Isodecyl Citrate derivatives have also seen significant progress. Recent work published in Organic & Biomolecular Chemistry (2024) described a novel enzymatic synthesis route using immobilized lipase B from Candida antarctica, achieving yields exceeding 85% with excellent regioselectivity. This green chemistry approach represents a substantial improvement over traditional chemical synthesis methods, reducing energy consumption by approximately 40% while eliminating the need for toxic catalysts.

From a toxicological perspective, comprehensive safety assessments of Isodecyl Citrate have been conducted to support its pharmaceutical applications. A 2023 regulatory toxicology study following OECD guidelines demonstrated no evidence of genotoxicity (Ames test, micronucleus assay) and established an acceptable daily intake of 10 mg/kg body weight. These findings have facilitated the compound's inclusion in the FDA's Inactive Ingredients Database for certain dosage forms, significantly expanding its potential pharmaceutical applications.

Looking forward, several research groups are investigating Isodecyl Citrate's potential as a bioactive molecule beyond its traditional roles as an excipient. Preliminary studies suggest possible anti-inflammatory properties through modulation of the NF-κB pathway, though these findings require further validation. The compound's unique combination of safety, stability, and potential bioactivity positions it as a multifaceted tool in chemical biology research and pharmaceutical development, warranting continued investigation across multiple applications.

• 77-93-0(Triethyl citrate)
• 77-94-1(Tributyl citrate)
• 24817-92-3(trihexyl O-acetylcitrate)
• 82469-79-2(trihexyl O-butyrylcitrate)
• 144-15-0(Acetyl trioctyl citrate)
• 77-89-4(Triethyl O-Acetylcitrate)
• 19958-02-2(Citric Acid 1,2-Diethyl Ester)
• 1587-20-8(Trimethyl citrate)
• 77-90-7(Tributyl O-Acetylcitrate)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)