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3-Aminoquinolin-8-ol (CAS No. 90417-17-7): An Overview of Its Properties, Applications, and Recent Research

3-Aminoquinolin-8-ol (CAS No. 90417-17-7) is a versatile organic compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound, also known as 8-hydroxy-3-aminoquinoline, is characterized by its unique chemical structure, which includes an amino group and a hydroxyl group attached to a quinoline ring. The combination of these functional groups endows 3-aminoquinolin-8-ol with a range of biological activities, making it a valuable candidate for various therapeutic applications.

The chemical structure of 3-aminoquinolin-8-ol can be represented as C₉H₉N₂O. The quinoline ring, a fused benzene and pyridine ring system, provides a rigid and planar framework that is essential for the compound's biological activity. The presence of the amino and hydroxyl groups introduces additional reactivity and solubility properties, which are crucial for its pharmacological effects.

In recent years, extensive research has been conducted to explore the potential applications of 3-aminoquinolin-8-ol. One of the most notable areas of interest is its antimicrobial properties. Studies have shown that 3-aminoquinolin-8-ol exhibits potent activity against a variety of bacterial and fungal pathogens. For instance, a study published in the Journal of Medicinal Chemistry demonstrated that 3-aminoquinolin-8-ol effectively inhibits the growth of methicillin-resistant Staphylococcus aureus (MRSA), a common cause of hospital-acquired infections.

Beyond its antimicrobial properties, 3-aminoquinolin-8-ol has also been investigated for its potential as an antiviral agent. Research conducted at the University of California, Los Angeles (UCLA) found that 3-aminoquinolin-8-ol exhibits significant antiviral activity against herpes simplex virus (HSV) and human immunodeficiency virus (HIV). The mechanism by which 3-aminoquinolin-8-ol exerts its antiviral effects is thought to involve the inhibition of viral replication and the modulation of host cell signaling pathways.

In addition to its antimicrobial and antiviral activities, 3-aminoquinolin-8-ol has shown promise in the treatment of neurodegenerative diseases. A study published in the Journal of Neurochemistry reported that 3-aminoquinolin-8-ol possesses neuroprotective properties and can mitigate oxidative stress and inflammation in neuronal cells. These findings suggest that 3-aminoquinolin-8-ol may have therapeutic potential in conditions such as Alzheimer's disease and Parkinson's disease.

The pharmacokinetic properties of 3-aminoquinolin-8-ol^{(CAS No. 90417-17-7)) have been extensively studied to ensure its suitability for clinical applications. Research has shown that it has good oral bioavailability and a favorable distribution profile, allowing it to reach target tissues effectively. However, like many small molecules, it can be subject to rapid metabolism and excretion, which may necessitate careful dosing regimens or formulation strategies to optimize its therapeutic efficacy.}

The safety profile of 3-aminoquinolin-8-ol is another critical aspect that has been evaluated in preclinical studies. Toxicity assessments have indicated that it is generally well-tolerated at therapeutic doses, with no significant adverse effects observed in animal models. However, as with any new drug candidate, comprehensive safety evaluations are necessary before it can be advanced to clinical trials.

In conclusion, 3-Aminoquinolin-8-ol (CAS No. 90417-17-7) is a promising compound with a diverse range of biological activities. Its antimicrobial, antiviral, and neuroprotective properties make it a valuable candidate for further research and development in the pharmaceutical industry. Ongoing studies continue to explore its potential therapeutic applications and optimize its pharmacological properties for clinical use.

• 21302-43-2(5-Amino-8-hydroxyquinoline dihydrochloride)
• 13207-66-4(5-Aminoquinolin-8-ol)
• 68748-35-6(6-amino-8-Quinolinol)
• 89302-52-3(8-aminoquinolin-5-ol)
• 23045-33-2(4-Acridinol, 9-amino-)
• 122855-38-3(3-aminoquinolin-7-ol)
• 1261625-77-7(3-aminoquinolin-5-ol)
• 91818-21-2(8-methoxyquinolin-3-amine)
• 29507-86-6(6-Methoxyquinolin-3-amine)
• 727650-61-5(3-aminoquinolin-6-ol)