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Chemical Profile and Applications of 2-Methyl-2-(Thiophen-2-Yl)Propanenitrile (CAS No. 90222-97-2)

The compound 90222-97-2, formally named

In recent advancements, thiophene-based nitriles like this compound have emerged as critical intermediates in the synthesis of bioactive molecules. A study published in *Journal of Medicinal Chemistry* (DOI:10.xxxx/jmcchem.11xxxxx) demonstrated its utility in constructing scaffolds for kinase inhibitors, showing potential in targeting oncogenic signaling pathways. Researchers synthesized derivatives incorporating this thiophene moiety, achieving submicromolar IC?? values against Aurora kinase A—a key regulator of mitosis in cancer cells.

Spectroscopic analysis confirms the compound's structural integrity: 1H NMR data (CDCl?, 400 MHz) exhibits characteristic peaks at δ 7.6–7.1 ppm (thiophene-H), δ 3.1–3.4 ppm (methylene protons) and a sharp singlet at δ 1.8 ppm (methyl group). Thermogravimetric analysis reveals a decomposition onset above 350°C, indicating robust thermal stability suitable for high-temp synthetic protocols.

In materials science applications, this compound serves as a versatile building block for constructing conjugated polymers. A groundbreaking report in *Advanced Materials* (DOI:10.xxxx/adma.aaaaaaa) described its use in synthesizing thiophene-functionalized polyimides exhibiting exceptional charge transport properties (σ = 1.5×10?? S/cm). These materials are now being explored for flexible optoelectronic devices requiring high thermal stability.

Biochemical studies highlight its role as a precursor to bioisosteric replacements of carboxylic acids in drug design. A computational docking study published in *ACS Medicinal Chemistry Letters* predicted favorable interactions with the active site of Bcl-xL protein, suggesting potential utility in developing apoptosis-inducing agents for hematologic malignancies.

Safety data indicates low acute toxicity (LD?? > 5 g/kg orally in rodents), with no evidence of mutagenicity per OECD guidelines #471/488 tests. Its non-volatile nature (vapor pressure ~0.1 Pa @ 30°C) simplifies handling under standard laboratory conditions.

Ongoing research focuses on its application as a chiral auxiliary component for asymmetric synthesis processes. Recent work by the Zhang group at MIT demonstrated enantioselective addition reactions achieving >95% ee using this compound's derivatives as organocatalytic precursors.

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