• 1. Exceptional activity of sub-nm Pt clusters on CdS for photocatalytic hydrogen production: a combined experimental and first-principles study?
  Qiyuan Wu,Shangmin Xiong,Peichuan Shen,Shen Zhao,Alexander Orlov Catal. Sci. Technol., 2015,5, 2059-2064
• 2. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126
• 3. Exceptionally high temperature spin crossover in amide-functionalised 2,6-bis(pyrazol-1-yl)pyridine iron(ii) complex revealed by variable temperature Raman spectroscopy and single crystal X-ray diffraction?
  Max Attwood,Hiroki Akutsu,Lee Martin,Toby J. Blundell,Pierre Le Maguere,Scott S. Turner Dalton Trans., 2021,50, 11843-11851
• 4. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502
• 5. Emergence of microfluidic wearable technologies
  Joo Chuan Yeo,Kenry Lab Chip, 2016,16, 4082-4090

Introduction to 2-Chloro-4-tridecanoylpyridine (CAS No. 898784-82-2)

2-Chloro-4-tridecanoylpyridine, with the chemical formula C14H22ClNO, is a significant compound in the field of pharmaceutical chemistry and organic synthesis. This compound, identified by its CAS number 898784-82-2, has garnered attention due to its versatile applications in the development of novel pharmaceutical agents and synthetic intermediates. The unique structural features of this molecule, particularly the presence of a chloro substituent and a tridecanoyl group attached to a pyridine ring, make it a valuable building block for various chemical reactions and biological assays.

The compound's molecular structure consists of a pyridine core, which is a six-membered aromatic heterocycle containing one nitrogen atom. This nitrogen atom is highly reactive and can participate in various coordination and functionalization reactions. The chloro group at the 2-position enhances the electrophilicity of the pyridine ring, making it susceptible to nucleophilic substitution reactions. Meanwhile, the tridecanoyl group at the 4-position introduces a long hydrocarbon chain, which can influence the compound's solubility, lipophilicity, and overall physicochemical properties.

In recent years, 2-Chloro-4-tridecanoylpyridine has been extensively studied for its potential applications in drug discovery and development. The compound's ability to serve as a precursor for more complex molecules has made it a favorite among medicinal chemists. For instance, it can be used to synthesize derivatives that exhibit inhibitory activity against various biological targets. One notable area of research involves its use in developing kinase inhibitors, which are crucial in treating cancers and inflammatory diseases.

Recent studies have highlighted the compound's role in the synthesis of small-molecule inhibitors targeting protein-protein interactions. These interactions are often involved in critical cellular processes and are considered attractive therapeutic targets. The pyridine moiety in 2-Chloro-4-tridecanoylpyridine can be modified to create specific binding pockets that interact with target proteins, leading to the development of potent and selective inhibitors. For example, modifications at the 3-position of the pyridine ring have been explored to enhance binding affinity and reduce off-target effects.

The tridecanoyl group in this compound also plays a crucial role in modulating its pharmacokinetic properties. By introducing a long hydrophobic chain, the compound can exhibit improved solubility in lipophilic environments, which is essential for drug delivery systems. This feature has been exploited in designing prodrugs and nanocarriers that enhance bioavailability and target specificity. Additionally, the presence of both chloro and acyl groups provides multiple sites for further functionalization, allowing for the creation of diverse chemical libraries for high-throughput screening.

Advances in computational chemistry have further enhanced the utility of 2-Chloro-4-tridecanoylpyridine in drug design. Molecular modeling techniques have been employed to predict how different modifications of this compound can affect its binding affinity and selectivity. These predictions have guided experimental efforts, leading to more efficient synthesis routes and optimized drug candidates. For instance, virtual screening has identified novel derivatives with enhanced potency against specific kinases, paving the way for new therapeutic strategies.

The compound's versatility extends beyond pharmaceutical applications. It has also been explored in materials science, particularly in the development of organic electronic materials. The pyridine ring can act as an electron-withdrawing group, influencing charge transport properties in organic semiconductors. Researchers have incorporated derivatives of 2-Chloro-4-tridecanoylpyridine into organic field-effect transistors (OFETs) to improve their performance metrics such as current density and on/off ratio.

In conclusion, 2-Chloro-4-tridecanoylpyridine (CAS No. 898784-82-2) is a multifaceted compound with significant potential in pharmaceuticals and materials science. Its unique structural features enable diverse chemical modifications, making it a valuable intermediate in drug discovery and synthesis. As research continues to uncover new applications for this compound, its importance in advancing scientific knowledge and technological innovation is likely to grow further.

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