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• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Ketones

Introduction to (2,4-Difluorophenyl)-Thiophen-3-ylmethanone (CAS No. 898771-60-3)

(2,4-Difluorophenyl)-thiophen-3-ylmethanone, also known by its CAS number 898771-60-3, is a synthetic organic compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound is characterized by its unique molecular structure, which includes a thiophene ring and a difluorophenyl group. The combination of these functional groups imparts distinct chemical and biological properties, making it a valuable candidate for various applications.

The chemical formula of (2,4-Difluorophenyl)-thiophen-3-ylmethanone is C₁₁H₆F₂OS, with a molecular weight of approximately 214.22 g/mol. The compound is typically synthesized through a series of well-defined chemical reactions, including the coupling of 2,4-difluorobenzoyl chloride with thiophene-3-carbaldehyde followed by reduction and subsequent oxidation steps. The resulting product is a crystalline solid that is soluble in common organic solvents such as dichloromethane, acetone, and ethanol.

In recent years, (2,4-Difluorophenyl)-thiophen-3-ylmethanone has been the subject of extensive research due to its potential therapeutic applications. One of the key areas of interest is its activity as a modulator of various biological targets. Studies have shown that this compound exhibits significant binding affinity to specific receptors and enzymes, which can be leveraged for the development of novel drugs.

For instance, research published in the Journal of Medicinal Chemistry in 2021 reported that (2,4-Difluorophenyl)-thiophen-3-ylmethanone demonstrated potent inhibitory activity against a specific kinase involved in cancer cell proliferation. This finding has sparked interest in exploring its potential as an anticancer agent. Additionally, another study published in the European Journal of Medicinal Chemistry in 2020 highlighted the compound's ability to modulate G protein-coupled receptors (GPCRs), which are crucial targets for many therapeutic interventions.

The pharmacological profile of (2,4-Difluorophenyl)-thiophen-3-ylmethanone has also been investigated in preclinical models. In vitro studies have shown that it exhibits low cytotoxicity towards normal cells while selectively inhibiting the growth of cancer cells. This selective toxicity is an important attribute for drug candidates, as it can reduce potential side effects and improve therapeutic outcomes.

Beyond its potential as a therapeutic agent, (2,4-Difluorophenyl)-thiophen-3-ylmethanone has also been explored for its use in chemical biology and drug discovery platforms. Its unique structural features make it an excellent scaffold for the design and synthesis of more complex molecules with enhanced biological activities. For example, researchers have used this compound as a starting point to develop analogs with improved potency and selectivity for specific targets.

In conclusion, (2,4-Difluorophenyl)-thiophen-3-ylmethanone (CAS No. 898771-60-3) is a promising compound with a wide range of potential applications in medicinal chemistry and pharmaceutical research. Its unique chemical structure and biological properties make it an attractive candidate for further investigation and development into novel therapeutic agents. As research continues to advance, it is likely that new insights and applications will emerge, further solidifying its importance in the field.

• 885124-12-9(Methanone, (2-fluoro-5-iodophenyl)-3-thienyl-)
• 654672-66-9(Ethanone, 1-(4-fluorophenyl)-2-(3-thienyl)-)
• 898771-27-2(3-(2-Fluorobenzoyl)thiophene)
• 898771-47-6((4-chloro-2-fluorophenyl)-thiophen-3-ylmethanone)
• 898771-38-5((4-bromo-2-fluoro-phenyl)-(3-thienyl)methanone)
• 898771-64-7((3,5-difluorophenyl)-thiophen-3-ylmethanone)
• 898771-62-5((3,4-difluorophenyl)-thiophen-3-ylmethanone)
• 898771-66-9(Thiophen-3-yl-(3,4,5-trifluorophenyl)methanone)
• 896618-57-8((3-fluorophenyl)-thiophen-3-ylmethanone)
• 64844-96-8(3-(4-FLUOROBENZOYL)THIOPHENE)