• 1. An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile?
  Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383
• 2. An arsenic trioxide nanoparticle prodrug (ATONP) potentiates a therapeutic effect on an aggressive hepatocellular carcinoma model via enhancement of intratumoral arsenic accumulation and disturbance of the tumor microenvironment?
  Xin Fu,Qing-rong Liang,Rong-guang Luo,Yan-shu Li,Xiao-ping Xiao,Lu-lu Yu,Wen-zhe Shan,Guang-qin Fan J. Mater. Chem. B, 2019,7, 3088-3099
• 3. An insight into the hybridization mechanism of hairpin DNA physically immobilized on chemically modified graphenes
  Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471
• 4. An ionic liquid-mesoporous silica blend as a novel adsorbent for the adsorption and recovery of palladium ions, and its applications in continuous flow study and as an industrial catalyst?
  Shivani Sharma,Chia-Ming Wu,Ranjit T. Koodali,N. Rajesh RSC Adv., 2016,6, 26668-26678
• 5. An artificial photosynthetic system for photoaccumulation of two electrons on a fused dipyridophenazine (dppz)–pyridoquinolinone ligand?
  Philipp Traber,Stephan Kupfer,Stefanie Gr?fe,Isabelle Baussanne,Martine Demeunynck,Jean-Marie Mouesca,Serge Gambarelli,Vincent Artero,Murielle Chavarot-Kerlidou Chem. Sci., 2018,9, 4152-4159

Comprehensive Overview of 1-methyl-4-[(piperidin-3-yl)methyl]piperazine (CAS No. 896054-84-5)

1-methyl-4-[(piperidin-3-yl)methyl]piperazine (CAS No. 896054-84-5) is a specialized organic compound that has garnered significant attention in pharmaceutical and chemical research due to its unique structural properties. This compound belongs to the class of piperazine derivatives, which are widely recognized for their versatility in drug design and medicinal chemistry. The presence of both piperidine and piperazine moieties in its structure makes it a valuable intermediate for synthesizing bioactive molecules targeting neurological and metabolic disorders.

In recent years, the demand for piperazine-based compounds has surged, driven by their applications in developing central nervous system (CNS) drugs and GPCR modulators. Researchers are particularly interested in 1-methyl-4-[(piperidin-3-yl)methyl]piperazine due to its potential role in enhancing blood-brain barrier (BBB) permeability, a critical factor in treating neurodegenerative diseases like Alzheimer's and Parkinson's. Its structural flexibility allows for modifications that can improve drug bioavailability and receptor binding affinity, making it a focal point in preclinical studies.

The synthesis of CAS No. 896054-84-5 involves multi-step organic reactions, including reductive amination and N-alkylation, which are optimized for high yield and purity. Analytical techniques such as HPLC, NMR spectroscopy, and mass spectrometry are employed to characterize this compound, ensuring compliance with pharmaceutical-grade standards. Its molecular weight (211.32 g/mol) and logP value (indicative of lipophilicity) further underscore its suitability for drug discovery pipelines.

Beyond pharmaceuticals, 1-methyl-4-[(piperidin-3-yl)methyl]piperazine is explored in agrochemical research for designing novel pesticide adjuvants. Its ability to modulate enzyme activity and ion channels aligns with the growing trend of green chemistry solutions in agriculture. Additionally, its stability under varying pH conditions makes it a candidate for catalysis and material science applications.

As the scientific community prioritizes sustainable synthesis and AI-driven drug discovery, compounds like CAS No. 896054-84-5 are increasingly studied through computational modeling and machine learning algorithms. These approaches accelerate the identification of structure-activity relationships (SAR), reducing reliance on traditional trial-and-error methods. This aligns with industry trends favoring high-throughput screening and fragment-based drug design.

In summary, 1-methyl-4-[(piperidin-3-yl)methyl]piperazine represents a promising scaffold for innovation across multiple disciplines. Its chemical properties, synthetic accessibility, and broad applicability position it as a key player in advancing life sciences and industrial chemistry. Future research will likely focus on optimizing its derivatives for targeted therapies and environmentally friendly formulations.

• 57184-38-0(1-(2-Ethylbutyl)piperazine)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)