• 1. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
• 2. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147
• 3. Fatty acid eutectic mixtures and derivatives from non-edible animal fat as phase change materials?
  Pau Gallart-Sirvent,Marc Martín,Gemma Villorbina,Mercè Balcells,Aran Solé,Luisa F. Cabeza,Ramon Canela-Garayoa RSC Adv., 2017,7, 24133-24139
• 4. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
  Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548
• 5. Emerging enantiomeric resolution materials with homochiral nano-fabrications
  Ji-Ping Wei Nanoscale, 2015,7, 11815-11832

4-(4-Chloro-phenyl)-2-p-tolyl-2H-pyrazol-3-ylamine: A Comprehensive Overview

4-(4-Chloro-phenyl)-2-p-tolyl-2H-pyrazol-3-ylamine (CAS No: 895029-27-3) is a fascinating compound with significant potential in various fields of chemistry and materials science. This compound, characterized by its unique structure and properties, has garnered attention from researchers due to its versatility and applicability in advanced chemical systems. The molecule consists of a pyrazole ring system, which is a five-membered aromatic heterocycle containing two nitrogen atoms. This core structure is further substituted with a 4-chlorophenyl group and a p-tolyl group, endowing the compound with distinctive electronic and steric properties.

The synthesis of 4-(4-Chloro-phenyl)-2-p-tolyl-2H-pyrazol-3-ylamine involves a series of well-established organic reactions, including nucleophilic substitution, condensation, and cyclization processes. Recent advancements in catalytic methods have enabled the efficient and selective preparation of this compound, ensuring high purity and yield. The use of transition metal catalysts, such as palladium complexes, has been particularly effective in facilitating key steps in its synthesis.

One of the most notable applications of this compound lies in its role as an intermediate in drug discovery. The pyrazole moiety is known for its ability to interact with various biological targets, making it a valuable component in the development of new pharmaceutical agents. For instance, studies have shown that derivatives of this compound exhibit potent anti-inflammatory and antioxidant activities, suggesting their potential use in treating conditions such as neurodegenerative diseases and cardiovascular disorders.

In addition to its biomedical applications, 4-(4-Chloro-phenyl)-2-p-tolyl-2H-pyrazol-3-ylamine has also found utility in materials science. Its ability to form stable coordination complexes with metal ions makes it an attractive candidate for use in catalysis and sensor technologies. Recent research has highlighted its potential as a ligand in homogeneous catalysis, where it facilitates the selective oxidation of alcohols to ketones under mild conditions.

The electronic properties of this compound are further enhanced by the presence of electron-withdrawing groups like the 4-chlorophenyl substituent. These groups modulate the reactivity of the pyrazole ring, enabling it to participate in various redox reactions. This characteristic has led to its exploration as an electrocatalyst in fuel cell applications, where it promotes efficient oxygen reduction reactions.

From a structural standpoint, the pyrazole ring serves as a versatile scaffold for further functionalization. The substitution pattern at positions 1 and 3 allows for the introduction of diverse functional groups, thereby expanding the scope of potential applications. For example, the introduction of hydroxamic acid groups has been shown to enhance metal-binding capabilities, making such derivatives valuable in chelation therapy.

Recent advancements in computational chemistry have provided deeper insights into the electronic structure and reactivity of 4-(4-Chloro-phenyl)-2-p-tolyl-2H-pyrazol-3-ylamine. Density functional theory (DFT) calculations have revealed that the compound exhibits significant conjugation across its aromatic system, contributing to its stability and reactivity. These findings have been instrumental in guiding experimental efforts toward optimizing its synthesis and application.

In conclusion, 4-(4-Chloro-phenyl)-2-p-tolyl-2H-pyrazol-3-ylamine (CAS No: 895029-27-3) stands out as a multifaceted compound with promising prospects across various domains of chemistry. Its unique structure, coupled with recent breakthroughs in synthesis and application techniques, positions it as a key player in advancing both fundamental research and industrial applications.

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