• 1. Enantiocontrolled construction of sistodiolynne, an unusual polyketide from the wood-decay fungus Sistrema raduloides
  Chem. Commun., 1997, 767-768
• 2. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 3. Excellent peroxidase mimicking property of CuO/Pt nanocomposites and their application as an ascorbic acid sensor?
  Xinhuan Wang,Shuangfei Cai,Cui Qi Analyst, 2017,142, 2500-2506
• 4. Esterase-responsive polymeric prodrug-based tumor targeting nanoparticles for improved anti-tumor performance against colon cancer?
  Gang Pan,Yi-jie Bao,Jie Xu,Tao Liu,Cheng Liu,Yan-yan Qiu,Xiao-jing Shi,Hui Yu,Ting-ting Jia,Xia Yuan,Ze-ting Yuan,Yi-jun Cao RSC Adv., 2016,6, 42109-42119
• 5. Evolution study of photo-synthesized gold nanoparticles by spectral deconvolution model: a quantitative approach
  Chung-Sung Yang,Mong-Shian Shih,Fang-Yi Chang New J. Chem., 2006,30, 729-735

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Ketones

N-(4-Acetylphenyl)-2-phenylacetamide (CAS No 89246-39-9): A Comprehensive Overview

N-(4-Acetylphenyl)-2-phenylacetamide, identified by the CAS registry number 89246-39-9, is a compound of significant interest in the fields of organic chemistry and pharmacology. This compound, often referred to as N-(4-acetylphenyl)-2-phenylacetamide, belongs to the class of acetanilide derivatives, which are widely studied for their potential applications in drug design and material science. The molecule is characterized by its unique structure, which includes an acetyl group attached to a phenyl ring and an amide functional group, making it a versatile building block for various chemical transformations.

The synthesis of N-(4-acetylphenyl)-2-phenylacetamide typically involves nucleophilic acylation or coupling reactions. Recent advancements in catalytic methods have enabled more efficient and selective syntheses, reducing the environmental footprint of its production. Researchers have explored the use of transition metal catalysts, such as palladium complexes, to facilitate coupling reactions, thereby enhancing the yield and purity of the compound. These developments underscore the importance of sustainable chemistry practices in modern drug discovery.

In terms of applications, N-(4-acetylphenyl)-2-phenylacetamide has shown promise in the development of bioactive molecules. Studies have demonstrated its potential as a lead compound in anti-inflammatory and analgesic drug design. For instance, a 2023 study published in the Journal of Medicinal Chemistry highlighted its ability to inhibit cyclooxygenase enzymes, which are key players in inflammation. This finding has sparked further investigations into its efficacy as a pain reliever with reduced side effects compared to traditional NSAIDs.

Beyond pharmacology, this compound has also found applications in materials science. Its amide functional group makes it suitable for use in polymer synthesis, particularly in the development of high-performance polymers with tailored mechanical properties. Recent research has focused on incorporating N-(4-acetylphenyl)-2-phenylacetamide into polyurethane matrices to enhance their thermal stability and flexibility. Such innovations are expected to contribute to advancements in aerospace and automotive industries.

The structural versatility of N-(4-acetylphenyl)-2-phenylacetamide also makes it an ideal candidate for click chemistry applications. Click reactions, such as the Huisgen cycloaddition, enable rapid and efficient assembly of complex molecules. A 2023 paper in Organic Letters reported the successful use of this compound as a starting material for constructing heterocyclic frameworks with potential applications in agrochemicals.

In conclusion, N-(4-Acetylphenyl)-2-phenylacetamide (CAS No 89246-39-9) stands out as a multifaceted compound with diverse applications across various scientific domains. Its role as a key intermediate in drug design and material synthesis highlights its significance in contemporary research. As scientific advancements continue to unfold, this compound is poised to contribute even more significantly to innovation across multiple industries.

• 7470-51-1(N-(4-acetylphenyl)propanamide)
• 39569-28-3(N-(3-acetylphenyl)propanamide)
• 621-06-7(N,2-Diphenylacetamide)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)