• 1. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
  Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548
• 2. Exciplex emission from the mixed dimer of naphthalene and 2-cyanonaphthalene in a supersonic jet
  Aloke Das,K. K. Mahato,Chayan K. Nandi,Tapas Chakraborty,Shridhar R. Gadre,Nikhil A. Gokhale Phys. Chem. Chem. Phys., 2002,4, 2162-2168
• 3. Evolution of cellulose into flexible conductive green electronics: a smart strategy to fabricate sustainable electrodes for supercapacitors
  Tengfei Yu,Yuehan Wu,Wei Li,Bin Li RSC Adv., 2014,4, 34134-34143
• 4. Fast-pulsing NMR techniques for the detection of weak interactions: successful natural abundance probe of hydrogen bonds in peptides?
  Amandine Altmayer-Henzien,Valérie Declerck,David J. Aitken,Ewen Lescop,Denis Merlet,Jonathan Farjon Org. Biomol. Chem., 2013,11, 7611-7615
• 5. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126

Comprehensive Guide to tert-Butyl 2-(bromomethyl)piperidine-1-carboxylate (CAS No. 889942-58-9)

tert-Butyl 2-(bromomethyl)piperidine-1-carboxylate (CAS No. 889942-58-9) is a versatile organic compound widely used in pharmaceutical and chemical research. This compound belongs to the class of piperidine derivatives, which are crucial intermediates in the synthesis of various bioactive molecules. With its unique bromomethyl functional group, it serves as a valuable building block in medicinal chemistry and drug discovery.

The molecular structure of tert-Butyl 2-(bromomethyl)piperidine-1-carboxylate features a piperidine ring substituted with a bromomethyl group at the 2-position and a tert-butoxycarbonyl (Boc) protecting group at the nitrogen. This combination enhances its reactivity and stability, making it ideal for multi-step synthetic routes. Researchers often utilize this compound in peptide coupling reactions, cross-coupling chemistry, and the preparation of heterocyclic compounds.

One of the key applications of tert-Butyl 2-(bromomethyl)piperidine-1-carboxylate is in the development of central nervous system (CNS) drugs. The piperidine moiety is a common pharmacophore found in many neurologically active compounds, including antidepressants, antipsychotics, and analgesics. Its bromomethyl group allows for further functionalization, enabling the creation of novel drug candidates with improved efficacy and selectivity.

In recent years, the demand for tert-Butyl 2-(bromomethyl)piperidine-1-carboxylate has surged due to its role in cancer research. Scientists are exploring its potential in designing kinase inhibitors and targeted therapies. The compound's ability to act as a scaffold for drug design has made it a focal point in oncology drug development, aligning with the growing interest in personalized medicine and precision oncology.

Another emerging application of tert-Butyl 2-(bromomethyl)piperidine-1-carboxylate is in the field of agrochemicals. Its structural features make it a promising candidate for developing pesticides and herbicides with enhanced environmental compatibility. As the agricultural industry shifts toward sustainable practices, this compound is gaining attention for its potential to contribute to green chemistry initiatives.

From a synthetic perspective, tert-Butyl 2-(bromomethyl)piperidine-1-carboxylate is valued for its compatibility with modern catalytic methods, such as palladium-catalyzed cross-coupling and photoredox catalysis. These advanced techniques enable efficient and selective transformations, reducing waste and improving yields. The compound's versatility aligns with the increasing demand for atom-economical and eco-friendly synthetic routes in both academia and industry.

Storage and handling of tert-Butyl 2-(bromomethyl)piperidine-1-carboxylate require standard laboratory precautions. It should be kept in a cool, dry place, away from moisture and direct sunlight. Proper personal protective equipment (PPE), including gloves and safety goggles, is recommended when working with this compound to ensure safe laboratory practices.

The market for tert-Butyl 2-(bromomethyl)piperidine-1-carboxylate is expected to grow steadily, driven by its expanding applications in pharmaceuticals, agrochemicals, and material science. With ongoing advancements in synthetic methodology and drug discovery, this compound will likely remain a key player in the fine chemicals sector. Researchers and manufacturers are continually exploring new ways to leverage its unique properties for innovative solutions.

In conclusion, tert-Butyl 2-(bromomethyl)piperidine-1-carboxylate (CAS No. 889942-58-9) is a highly valuable chemical intermediate with broad applications across multiple industries. Its role in drug development, agrochemical innovation, and sustainable chemistry underscores its importance in modern science. As research progresses, this compound will undoubtedly continue to contribute to groundbreaking discoveries and technological advancements.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)