• 1. Evolutionary de novo design of phenothiazine derivatives for dye-sensitized solar cells?
  Vishwesh Venkatraman,Marco Foscato,Vidar R. Jensen,Bj?rn K?re Alsberg J. Mater. Chem. A, 2015,3, 9851-9860
• 2. Dissociation of aryl sulfonyl phthalimide radical anions: relevance to the biological activity of arylsulfonyl amides?
  Abdelaziz Houmam,Emad M. Hamed Chem. Commun., 2012,48, 11328-11330
• 3. Fast synthesis of red Li3BaSrLn3(WO4)8:Eu3+ phosphors for white LEDs under near-UV excitation by a microwave-assisted solid state reaction method and photoluminescence studies
  Bo Wei,Zhenyu Liu,Chen Xie,Shu Yang,Wentao Tang,Aiwei Gu,Wing-Tak Wong,Ka-Leung Wong J. Mater. Chem. C, 2015,3, 12322-12327
• 4. Evolution and characterization of a benzylguanine-binding RNA aptamer?
  J. Xu,T. J. Carrocci,A. A. Hoskins Chem. Commun., 2016,52, 549-552
• 5. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Phenylpyridines

5-(2-Methylphenyl)nicotinic Acid (CAS No 887973-51-5): A Comprehensive Overview

5-(2-Methylphenyl)nicotinic Acid, also known by its CAS number 887973-51-5, is a compound of significant interest in the fields of organic chemistry and pharmacology. This compound belongs to the class of nicotinic acids, which are derivatives of nicotinic acid, a well-known precursor to niacin (vitamin B3). The structure of 5-(2-Methylphenyl)nicotinic Acid consists of a nicotinic acid moiety substituted with a methylphenyl group at the 5-position, which imparts unique chemical and biological properties to the molecule.

The synthesis of 5-(2-Methylphenyl)nicotinic Acid typically involves multi-step organic reactions, often utilizing coupling agents and protecting groups to achieve the desired substitution pattern. Recent advancements in catalytic methods have enabled more efficient and selective syntheses, reducing production costs and improving yields. Researchers have also explored green chemistry approaches, such as using microwave-assisted synthesis or enzymatic catalysis, to synthesize this compound in an environmentally friendly manner.

5-(2-Methylphenyl)nicotinic Acid has been studied extensively for its potential applications in drug discovery. The compound exhibits interesting pharmacological properties, including anti-inflammatory and antioxidant activities. A study published in the Journal of Medicinal Chemistry highlighted its ability to inhibit certain enzymes associated with neurodegenerative diseases, suggesting its potential as a lead compound for developing treatments for Alzheimer's disease. Furthermore, preclinical trials have shown that this compound may possess anti-cancer properties by modulating key signaling pathways involved in tumor growth and metastasis.

In addition to its pharmacological applications, 5-(2-Methylphenyl)nicotinic Acid has found utility in materials science. Its ability to form stable coordination complexes with metal ions has led to its use in designing novel materials for sensing applications. For instance, researchers have reported the use of this compound as a ligand in constructing metal-organic frameworks (MOFs) that exhibit high sensitivity towards certain gases, such as nitrogen dioxide and ammonia. These findings underscore its versatility across multiple scientific disciplines.

The toxicological profile of 5-(2-Methylphenyl)nicotinic Acid has also been investigated to ensure its safety for various applications. Acute toxicity studies indicate that the compound has a relatively low toxicity profile when administered at therapeutic doses. However, chronic exposure studies are still ongoing to fully understand its long-term effects on biological systems. Regulatory agencies have classified this compound under general chemical safety guidelines, emphasizing the need for proper handling and storage procedures.

Recent research has also explored the environmental impact of 5-(2-Methylphenyl)nicotinic Acid. Studies conducted on its biodegradation kinetics reveal that it undergoes rapid microbial degradation under aerobic conditions, minimizing its persistence in natural ecosystems. This is particularly important for applications where large-scale production or disposal might occur, ensuring that it aligns with sustainability goals.

In conclusion, 5-(2-Methylphenyl)nicotinic Acid (CAS No 887973-51-5) is a versatile compound with promising applications in pharmacology, materials science, and environmental chemistry. Its unique chemical structure and favorable biological properties make it an attractive candidate for further research and development. As scientific advancements continue to unfold, this compound is likely to play an increasingly significant role in both academic and industrial settings.

• 68937-93-9(5-p-Tolylnicotinic acid)
• 597565-52-1(5-(4-Carboxyphenyl)nicotinic acid)
• 566198-34-3(5-(3-formylphenyl)pyridine-3-carboxylic acid)
• 928148-47-4(3-(3-Hydroxymethylphenyl)isonicotinic acid)
• 1048486-24-3(5-(3,5-Dimethylphenyl)nicotinic acid)
• 10177-12-5(5-phenylpyridine-3-carboxylic acid)
• 566198-28-5(5-(4-Formylphenyl)nicotinic acid)
• 1970-81-6([3,3'-Bipyridine]-5-carboxylic acid)
• 893737-23-0(5-(p-Tolyl)nicotinic acid)
• 887973-34-4(5-(m-Tolyl)nicotinic acid)