• 1. Dissolved oxygen sensor based on fluorescence quenching of oxygen-sensitive ruthenium complexes immobilized in sol–gel-derived porous silica coatings
  Analyst, 1996,121, 785-788
• 2. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)
  Eléonore Resongles,Corinne Casiot,Fran?oise Elbaz-Poulichet,Rémi Freydier,Odile Bruneel,Christine Piot,Sophie Delpoux,Aurélie Volant,Angélique Desoeuvre Environ. Sci.: Processes Impacts, 2013,15, 1536-1544
• 3. Fe(ii)-Assisted one-pot synthesis of ultra-small core–shell Au–Pt nanoparticles as superior catalysts towards the HER and ORR?
  Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466
• 4. Fc microparticles can modulate the physical extent and magnitude of complement activity?
  David White,Sean R. Stowell Biomater. Sci., 2017,5, 463-474
• 5. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazinanes Phenylpiperazines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazinanes Piperazines Phenylpiperazines

Comprehensive Guide to tert-Butyl 3-(2-methoxyphenyl)piperazine-1-carboxylate (CAS No. 886768-01-0)

tert-Butyl 3-(2-methoxyphenyl)piperazine-1-carboxylate (CAS No. 886768-01-0) is a specialized organic compound that has garnered significant attention in pharmaceutical and chemical research. This compound, often referred to as a piperazine derivative, is widely utilized in the synthesis of bioactive molecules and drug intermediates. Its unique structure, featuring a tert-butyl carboxylate group and a methoxyphenyl moiety, makes it a versatile building block in medicinal chemistry.

The molecular formula of tert-Butyl 3-(2-methoxyphenyl)piperazine-1-carboxylate is C₁₆H₂₄N₂O₃, with a molecular weight of approximately 292.38 g/mol. The compound is characterized by its piperazine ring, which is a common scaffold in many pharmaceuticals due to its ability to enhance solubility and bioavailability. The presence of the methoxy group at the ortho position of the phenyl ring further contributes to its reactivity and potential applications.

One of the key reasons for the growing interest in tert-Butyl 3-(2-methoxyphenyl)piperazine-1-carboxylate is its role in the development of CNS-active compounds. Researchers are increasingly exploring its potential in designing molecules that target neurological disorders, such as anxiety and depression. This aligns with the current trend in the pharmaceutical industry, where there is a high demand for novel neuroprotective agents and psychoactive drugs.

In addition to its pharmaceutical applications, tert-Butyl 3-(2-methoxyphenyl)piperazine-1-carboxylate is also used in academic and industrial research as a chemical intermediate. Its stability and reactivity make it an ideal candidate for multi-step synthetic routes, particularly in the preparation of complex heterocyclic compounds. This has led to its inclusion in numerous patent applications and research publications.

The synthesis of tert-Butyl 3-(2-methoxyphenyl)piperazine-1-carboxylate typically involves the reaction of 2-methoxyphenylpiperazine with tert-butyl chloroformate under controlled conditions. The process requires careful optimization to achieve high yields and purity, which are critical for its subsequent use in drug development. Advanced analytical techniques, such as NMR spectroscopy and mass spectrometry, are employed to confirm the structure and purity of the final product.

From a market perspective, the demand for tert-Butyl 3-(2-methoxyphenyl)piperazine-1-carboxylate is expected to rise due to its expanding applications in drug discovery and medicinal chemistry. The compound is often listed in catalogs of specialty chemical suppliers, catering to the needs of research institutions and pharmaceutical companies. Its price and availability may vary depending on the scale of production and the supplier's location.

Safety and handling of tert-Butyl 3-(2-methoxyphenyl)piperazine-1-carboxylate are also important considerations. While it is not classified as a hazardous material, standard laboratory precautions should be followed, including the use of personal protective equipment (PPE) and proper ventilation. Researchers are advised to consult the material safety data sheet (MSDS) for detailed information on its handling and storage.

In summary, tert-Butyl 3-(2-methoxyphenyl)piperazine-1-carboxylate (CAS No. 886768-01-0) is a valuable compound with diverse applications in pharmaceutical research and chemical synthesis. Its unique structural features and reactivity make it a promising candidate for the development of new therapeutic agents. As the demand for innovative drug candidates continues to grow, this compound is likely to remain a focal point of scientific investigation.

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