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• 2. An Appraisal of pH triggered Bacitracin drug release, through composite hydrogel systems
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• 3. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
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• 4. An anti-leakage liquid metal thermal interface material
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• 5. Aggregated-fluorescent detection of PFAS with a simple chip
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• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides

1-(2-Fluorophenyl)cyclopropanamine: A Comprehensive Overview of CAS No. 886366-50-3

1-(2-Fluorophenyl)cyclopropanamine (CAS No. 886366-50-3) is a synthetic compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound, characterized by its unique cyclopropane ring and fluorinated phenyl group, exhibits a range of biological activities that make it a valuable candidate for various therapeutic applications.

The molecular structure of 1-(2-Fluorophenyl)cyclopropanamine is composed of a cyclopropane ring attached to a 2-fluorophenyl group through an amine linkage. The cyclopropane ring, known for its high reactivity due to its strained three-membered ring, imparts unique chemical properties to the molecule. The presence of the fluorine atom in the phenyl group further enhances the compound's stability and bioavailability, making it an attractive target for drug development.

Recent studies have explored the potential of 1-(2-Fluorophenyl)cyclopropanamine in various therapeutic areas. One notable application is in the treatment of neurological disorders. Research has shown that this compound can modulate specific neurotransmitter systems, such as the serotonin and dopamine pathways, which are implicated in conditions like depression and Parkinson's disease. A study published in the Journal of Medicinal Chemistry highlighted the ability of 1-(2-Fluorophenyl)cyclopropanamine to act as a selective serotonin reuptake inhibitor (SSRI), suggesting its potential as an antidepressant agent.

In addition to its neurological effects, 1-(2-Fluorophenyl)cyclopropanamine has been investigated for its anti-inflammatory properties. Inflammation is a key factor in many chronic diseases, including arthritis and cardiovascular disorders. Preclinical studies have demonstrated that this compound can inhibit the production of pro-inflammatory cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), thereby reducing inflammation and associated tissue damage.

The pharmacokinetic profile of 1-(2-Fluorophenyl)cyclopropanamine has also been extensively studied. Its high lipophilicity and low molecular weight contribute to favorable absorption and distribution characteristics, allowing it to readily cross biological membranes, including the blood-brain barrier. This property is particularly advantageous for central nervous system (CNS) disorders where drug delivery to the brain is crucial.

Clinical trials are currently underway to evaluate the safety and efficacy of 1-(2-Fluorophenyl)cyclopropanamine in human subjects. Preliminary results from Phase I trials have shown promising outcomes with minimal adverse effects, paving the way for further investigation in larger patient populations. The compound's favorable safety profile is attributed to its well-characterized metabolic pathways and low toxicity levels.

Beyond its therapeutic applications, 1-(2-Fluorophenyl)cyclopropanamine has also found use as a research tool in academic and industrial laboratories. Its unique chemical structure makes it an excellent model compound for studying cyclopropane ring chemistry and fluorine-substituted aromatic compounds. Researchers have utilized this compound to develop new synthetic methods and explore novel reaction mechanisms, contributing to advancements in organic chemistry.

In conclusion, 1-(2-Fluorophenyl)cyclopropanamine (CAS No. 886366-50-3) represents a promising molecule with diverse applications in medicinal chemistry and pharmaceutical research. Its unique structural features and biological activities make it a valuable candidate for further development as a therapeutic agent. Ongoing research continues to uncover new insights into its mechanisms of action and potential clinical uses, solidifying its position as a key player in modern drug discovery efforts.

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• 1209947-02-3(1-(2,5-difluorophenyl)cyclopropan-1-amine)
• 474709-81-4(1-(2,4-difluorophenyl)cyclopropan-1-amine)
• 1260667-54-6(1-(2,3-difluorophenyl)cyclopropan-1-amine)
• 1186663-18-2(1-(2,4-Difluorophenyl)cyclopropylamine hydrochloride)
• 1168139-58-9((1R)-1-(2-fluorophenyl)propan-1-amine)
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• 473249-01-3(1-(2-FLUOROPHENYL)PROPYLAMINE)
• 1215107-57-5(1-(2-Fluorophenyl)cyclopropan-1-amine hydrochloride)