• 1. Ester-directed orthogonal dual C–H activation and ortho aryl C–H alkenylation via distal weak coordination?
  Manickam Bakthadoss,Tadiparthi Thirupathi Reddy,Vishal Agarwal,Duddu S. Sharada Chem. Commun., 2022,58, 1406-1409
• 2. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198
• 3. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147
• 4. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 5. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
  Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Indoles and derivatives Hydroxyindoles

Comprehensive Overview of 4-Chloro-1H-indol-6-ol (CAS No. 885520-20-7): Properties, Applications, and Research Insights

4-Chloro-1H-indol-6-ol (CAS No. 885520-20-7) is a specialized organic compound belonging to the indole derivatives family, which has garnered significant attention in pharmaceutical and biochemical research. This compound, characterized by its chloro-substituted indole structure, serves as a critical intermediate in the synthesis of bioactive molecules. Its unique chemical properties, including reactivity and solubility, make it a valuable asset in drug discovery and material science. Researchers and industries are increasingly exploring its potential due to its structural versatility and compatibility with modern synthetic methodologies.

The growing interest in 4-Chloro-1H-indol-6-ol aligns with the surge in demand for heterocyclic compounds in medicinal chemistry. Indole derivatives, in particular, are pivotal in designing drugs targeting neurological disorders, inflammation, and metabolic diseases. With the rise of AI-driven drug discovery and high-throughput screening, compounds like 4-Chloro-1H-indol-6-ol are being scrutinized for their binding affinities and pharmacokinetic profiles. This compound’s chloro group enhances its electrophilic properties, enabling precise modifications for tailored applications.

From an industrial perspective, 4-Chloro-1H-indol-6-ol is utilized in the development of fluorescent probes and organic semiconductors. Its electron-rich indole core facilitates charge transport, making it relevant in optoelectronic devices. Additionally, its role in green chemistry initiatives is noteworthy, as researchers seek sustainable synthesis routes to minimize environmental impact. The compound’s stability under varying pH conditions further broadens its utility in bioconjugation and catalysis.

Recent advancements in cryo-EM and X-ray crystallography have enabled detailed structural analyses of 4-Chloro-1H-indol-6-ol complexes, revealing insights into its molecular interactions. These studies are pivotal for optimizing its efficacy in enzyme inhibition and receptor modulation. Furthermore, the compound’s compatibility with click chemistry protocols has expanded its use in biomarker labeling and diagnostic imaging.

In the context of personalized medicine, 4-Chloro-1H-indol-6-ol is being investigated for its potential in targeted therapy. Its ability to act as a scaffold for kinase inhibitors has implications in oncology and immunology. As the scientific community prioritizes drug repurposing, this compound’s multifaceted applications continue to evolve, addressing unmet medical needs.

To conclude, 4-Chloro-1H-indol-6-ol (CAS No. 885520-20-7) exemplifies the convergence of chemistry, biology, and technology. Its adaptability across drug development, material science, and diagnostics underscores its importance in contemporary research. With ongoing innovations in synthetic biology and nanotechnology, this compound is poised to play a transformative role in future scientific breakthroughs.

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