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Comprehensive Overview of 4-Fluoro-6-nitro-1H-indazole (CAS No. 885520-01-4): Properties, Applications, and Research Insights

4-Fluoro-6-nitro-1H-indazole (CAS No. 885520-01-4) is a fluorinated nitro-indazole derivative that has garnered significant attention in pharmaceutical and agrochemical research due to its unique structural features. This heterocyclic compound belongs to the indazole family, characterized by a fused benzene and pyrazole ring system. The presence of both fluoro and nitro substituents at the 4- and 6-positions, respectively, enhances its reactivity and potential as a building block for advanced molecular designs.

In recent years, the demand for fluorinated compounds like 4-Fluoro-6-nitro-1H-indazole has surged, driven by their applications in drug discovery and material science. Researchers frequently search for terms such as "indazole derivatives synthesis", "fluoro-nitro indazole applications", and "CAS 885520-01-4 supplier", reflecting the compound's relevance in modern chemistry. Its structural versatility allows for modifications that can lead to novel bioactive molecules, particularly in the development of kinase inhibitors and antimicrobial agents.

The physicochemical properties of 4-Fluoro-6-nitro-1H-indazole include a molecular weight of 195.13 g/mol and a melting point range of 180–185°C, making it suitable for high-temperature reactions. Its solubility profile—moderate in polar organic solvents like DMSO and methanol but low in water—aligns with its use in organic synthesis. Analytical techniques such as HPLC, NMR, and mass spectrometry are commonly employed to characterize this compound, ensuring purity and consistency for research purposes.

One of the trending topics in the scientific community is the exploration of sustainable synthesis methods for heterocyclic compounds. 4-Fluoro-6-nitro-1H-indazole has been studied in the context of green chemistry, with researchers investigating catalyst-free reactions and solvent-free conditions to minimize environmental impact. This aligns with the growing interest in "eco-friendly chemical synthesis" and "green pharmaceuticals", which are frequently searched keywords in academic and industrial databases.

Beyond pharmaceuticals, 4-Fluoro-6-nitro-1H-indazole has potential applications in materials science, particularly in the development of organic electronic materials. Its electron-withdrawing nitro group and aromatic system make it a candidate for designing charge-transfer complexes and luminescent materials. Searches for "indazole-based OLED materials" and "nitro-heterocycles in electronics" highlight this emerging interest.

Quality control and regulatory compliance are critical for laboratories handling CAS No. 885520-01-4. Reputable suppliers provide certificates of analysis (CoA) detailing purity (often ≥98%), residual solvents, and heavy metal content. Researchers are advised to verify these parameters, especially when the compound is used in sensitive applications like bioconjugation or high-throughput screening.

In summary, 4-Fluoro-6-nitro-1H-indazole represents a versatile scaffold with broad interdisciplinary relevance. Its integration into drug discovery pipelines and material innovation continues to inspire scientific inquiry, as evidenced by the increasing volume of peer-reviewed publications and patent filings referencing this compound. Future research may focus on optimizing its synthetic routes and expanding its utility in cutting-edge technologies.

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