Cas no 885519-61-9 (6-Nitro-4-(1H)-indazole-carboxylic Acid)

6-Nitro-4-(1H)-indazole-carboxylic Acid is a nitro-substituted indazole derivative with a carboxylic acid functional group, making it a versatile intermediate in organic synthesis and pharmaceutical research. Its indazole core structure is of particular interest in medicinal chemistry due to its potential biological activity, often serving as a scaffold for drug development. The nitro group enhances reactivity, facilitating further derivatization, while the carboxylic acid moiety allows for conjugation or salt formation. This compound is typically employed in the synthesis of heterocyclic compounds, agrochemicals, and bioactive molecules. Its high purity and well-defined structure ensure reproducibility in research applications. Proper handling is advised due to potential sensitivity to heat or friction.
6-Nitro-4-(1H)-indazole-carboxylic Acid structure
885519-61-9 structure
Product Name:6-Nitro-4-(1H)-indazole-carboxylic Acid
CAS No:885519-61-9
MF:C8H5N3O4
MW:207.143001317978
MDL:MFCD07781677
CID:840439
PubChem ID:24728266
Update Time:2025-09-17

6-Nitro-4-(1H)-indazole-carboxylic Acid Chemical and Physical Properties

Names and Identifiers

    • 6-Nitro-1H-indazole-4-carboxylic acid
    • 6-NITRO-1H-INDAZOL-4-CARBOXYLIC ACID
    • 6-Nitro-4-(1H)indazole carboxylic acid
    • 6-Nitro-4-(1H)indazole carboxylic acid
    • YAHBWBBCYGPFHL-UHFFFAOYSA-N
    • 4325AC
    • 6-Nitro-1H-indazol-4-carboxylicacid
    • AK102176
    • AX8233715
    • DTXSID70646313
    • AS-63036
    • AKOS015856032
    • I11031
    • J-518949
    • MFCD07781677
    • FT-0701382
    • AMY9944
    • 885519-61-9
    • SCHEMBL2919924
    • 6-nitro-1H-indazole-4-carboxylicacid
    • SB39574
    • CS-0315478
    • 6-Nitro-4-(1H)-indazole-carboxylic Acid
    • MDL： MFCD07781677
    • Inchi： 1S/C8H5N3O4/c12-8(13)5-1-4(11(14)15)2-7-6(5)3-9-10-7/h1-3H,(H,9,10)(H,12,13)
    • InChI Key： YAHBWBBCYGPFHL-UHFFFAOYSA-N
    • SMILES： OC(C1=CC(=CC2=C1C=NN2)[N+](=O)[O-])=O

Computed Properties

  • Exact Mass: 207.02800565g/mol
  • Monoisotopic Mass: 207.02800565g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 5
  • Heavy Atom Count: 15
  • Rotatable Bond Count: 1
  • Complexity: 290
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 112
  • XLogP3: 0.9

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6-Nitro-4-(1H)-indazole-carboxylic Acid Suppliers

Suzhou Senfeida Chemical Co., Ltd
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(CAS:885519-61-9)6-Nitro-1H-indazol-4-carboxylic acid
Order Number:sfd837
Stock Status:in Stock
Quantity:200kg
Purity:99.9%
Pricing Information Last Updated:Friday, 19 July 2024 14:32
Price ($):discuss personally

6-Nitro-4-(1H)-indazole-carboxylic Acid Related Literature

Additional information on 6-Nitro-4-(1H)-indazole-carboxylic Acid

6-Nitro-4-(1H)-Indazole-carboxylic Acid: A Comprehensive Overview

6-Nitro-4-(1H)-indazole-carboxylic acid, identified by the CAS number 885519-61-9, is a compound of significant interest in the fields of organic chemistry and pharmacology. This compound belongs to the class of indazole derivatives, which have been extensively studied for their diverse biological activities. The structure of 6-nitro-4-(1H)-indazole-carboxylic acid consists of an indazole ring system with a nitro group at the 6-position and a carboxylic acid group at the 4-position, making it a unique derivative with potential applications in drug discovery and chemical synthesis.

The synthesis of 6-nitro-4-(1H)-indazole-carboxylic acid involves a series of carefully designed reactions, including nitration and carboxylation steps. Recent advancements in synthetic methodologies have enabled researchers to optimize the yield and purity of this compound, making it more accessible for further studies. The nitro group at the 6-position plays a crucial role in modulating the electronic properties of the molecule, while the carboxylic acid group introduces acidity and enhances solubility in polar solvents.

6-Nitro-4-(1H)-indazole-carboxylic acid has been explored for its potential as a pharmacophore in various therapeutic areas. For instance, studies have shown that this compound exhibits significant antioxidant activity, which could be beneficial in combating oxidative stress-related diseases such as neurodegenerative disorders and cardiovascular diseases. Additionally, research has highlighted its potential as an anti-inflammatory agent, with promising results in reducing inflammation in experimental models.

The pharmacokinetic properties of 6-nitro-4-(1H)-indazole-carboxylic acid have also been investigated, revealing favorable absorption and distribution profiles. These findings suggest that the compound could be developed into an orally bioavailable drug. Furthermore, recent studies have explored its ability to modulate key cellular pathways involved in cancer progression, such as the MAPK/ERK pathway, indicating its potential as an anticancer agent.

In terms of structural modifications, researchers have been actively exploring analogs of 6-nitro-4-(1H)-indazole-carboxylic acid to enhance its bioactivity and reduce potential side effects. For example, substituting the nitro group with other electron-withdrawing or donating groups has been shown to significantly alter the compound's pharmacological profile. These efforts are part of a broader trend in medicinal chemistry aimed at designing more effective and safer therapeutic agents.

The application of advanced computational techniques, such as molecular docking and QSAR modeling, has further enhanced our understanding of 6-nitro-4-(1H)-indazole-carboxylic acid's interactions with biological targets. These computational studies have provided valuable insights into the binding modes and key residues responsible for the compound's activity, paving the way for rational drug design.

In conclusion, 6-nitro-4-(1H)-indazole-carboxylic acid, with its unique structure and diverse biological activities, represents a promising lead compound for drug development. Ongoing research continues to uncover new insights into its mechanism of action and therapeutic potential, underscoring its importance in contemporary medicinal chemistry.

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