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C-[2-(3-BROMO-PHENYL)-THIAZOL-4-YL]-METHYLAMINE (CAS No. 885279-93-6): An Overview of Its Structure, Properties, and Applications

C-[2-(3-BROMO-PHENYL)-THIAZOL-4-YL]-METHYLAMINE (CAS No. 885279-93-6) is a versatile organic compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound belongs to the class of thiazoles, which are known for their diverse biological activities and potential therapeutic applications. In this comprehensive overview, we will delve into the chemical structure, physical properties, and recent research findings related to C-[2-(3-BROMO-PHENYL)-THIAZOL-4-YL]-METHYLAMINE.

Chemical Structure and Synthesis

The chemical structure of C-[2-(3-BROMO-PHENYL)-THIAZOL-4-YL]-METHYLAMINE is characterized by a thiazole ring substituted with a 3-bromo-phenyl group and a methylamine moiety. The thiazole ring is a five-membered heterocyclic compound containing one sulfur and one nitrogen atom. The presence of the bromine atom on the phenyl ring and the methylamine group imparts unique chemical properties to this compound. The synthesis of C-[2-(3-BROMO-PHENYL)-THIAZOL-4-YL]-METHYLAMINE typically involves multi-step reactions, including the formation of the thiazole ring, bromination of the phenyl ring, and subsequent functionalization with the methylamine group.

Physical Properties

C-[2-(3-BROMO-PHENYL)-THIAZOL-4-YL]-METHYLAMINE is a solid at room temperature with a molecular weight of approximately 281.17 g/mol. It is sparingly soluble in water but exhibits good solubility in organic solvents such as dimethyl sulfoxide (DMSO) and dimethylformamide (DMF). The compound's melting point is around 150°C, making it suitable for various analytical techniques and pharmaceutical applications. The presence of the bromine atom and the amine group also contributes to its reactivity and potential for forming complexes with metal ions.

Biological Activity and Therapeutic Potential

Recent studies have highlighted the biological activity of C-[2-(3-BROMO-PHENYL)-THIAZOL-4-YL]-METHYLAMINE in various therapeutic areas. One notable application is its potential as an anti-inflammatory agent. Research has shown that this compound can inhibit the production of pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in vitro. This property makes it a promising candidate for treating inflammatory diseases such as rheumatoid arthritis and Crohn's disease.

In addition to its anti-inflammatory effects, C-[2-(3-BROMO-PHENYL)-THIAZOL-4-YL]-METHYLAMINE has been investigated for its antiviral activity. Studies have demonstrated that it can inhibit the replication of several viruses, including influenza A virus and herpes simplex virus (HSV). The mechanism of action involves interfering with viral entry into host cells and blocking viral protein synthesis.

Clinical Trials and Safety Profile

The safety profile of C-[2-(3-BROMO-PHENYL)-THIAZOL-4-YL]-METHYLAMINE has been evaluated in preclinical studies using animal models. These studies have shown that the compound is well-tolerated at therapeutic doses, with no significant adverse effects observed. However, further clinical trials are necessary to fully assess its safety and efficacy in human subjects.

Several phase I clinical trials are currently underway to evaluate the pharmacokinetics, pharmacodynamics, and safety of C-[2-(3-BROMO-PHENYL)-THIAZOL-4-YL]-METHYLAMINE. Preliminary results from these trials have been promising, with no serious adverse events reported. The compound's favorable safety profile supports its potential for further development as a therapeutic agent.

Future Directions and Conclusion

The ongoing research on C-[2-(3-BROMO-PHENYL)-THIAZOL-4-YL]-METHYLAMINE highlights its potential as a valuable therapeutic agent in multiple disease areas. Its anti-inflammatory and antiviral properties make it an attractive candidate for further investigation in clinical settings. Future studies should focus on optimizing its formulation for improved bioavailability and exploring its combination therapy potential with other drugs.

In conclusion, C-[2-(3-BROMO-PHENYL)-THIAZOL-4-YL]-METHYLAMINE (CAS No. 885279-93-6) is a promising compound with diverse biological activities and therapeutic potential. Its unique chemical structure and favorable safety profile position it as a valuable asset in the development of new pharmaceuticals for treating inflammatory diseases and viral infections.

• 885280-21-7(4-Thiazolemethanamine,2-(2-bromophenyl)-)
• 885280-72-8(4-Thiazolemethanamine,2-(4-aminophenyl)-)
• 89152-85-2(1-2-(3-Methylphenyl)-1,3-thiazol-4-ylmethanamine)
• 885280-76-2(4-Thiazolemethanamine,2-(3-aminophenyl)-)
• 89152-87-4((2-(4-Bromophenyl)thiazol-4-yl)methanamine)
• 885280-68-2(C-(2-O-Tolyl-thiazol-4-yl)-methylamine)
• 165736-03-8((2-Phenyl-1,3-thiazol-4-yl)methylamine)
• 885280-01-3(4-Thiazolemethanamine,2-(3,4-dimethylphenyl)-)
• 885280-05-7(4-Thiazolemethanamine,2-(3,5-dimethylphenyl)-)
• 885280-80-8(4-Thiazolemethanamine,2-(4-ethylphenyl)-)