Cas no 885278-87-5 (2-(4-Hydroxyphenyl)thiazole-4-carbaldehyde)

2-(4-Hydroxyphenyl)thiazole-4-carbaldehyde is a versatile heterocyclic compound featuring a hydroxyphenyl group attached to a thiazole core with a formyl functional group at the 4-position. This structure imparts reactivity suitable for further derivatization, making it valuable in organic synthesis and pharmaceutical research. The presence of both hydroxyl and aldehyde groups allows for selective modifications, enabling applications in the development of bioactive molecules, coordination chemistry, and material science. Its well-defined aromatic and heterocyclic framework contributes to stability and predictable reactivity, facilitating its use as a building block in complex molecular architectures. The compound is typically handled under standard laboratory conditions, with purity and consistency being key considerations for research applications.
2-(4-Hydroxyphenyl)thiazole-4-carbaldehyde structure
885278-87-5 structure
Product Name:2-(4-Hydroxyphenyl)thiazole-4-carbaldehyde
CAS No:885278-87-5
MF:C10H7NO2S
MW:205.233081102371
MDL:MFCD06738378
CID:711600
PubChem ID:135741988
Update Time:2025-05-20

2-(4-Hydroxyphenyl)thiazole-4-carbaldehyde Chemical and Physical Properties

Names and Identifiers

    • 2-(4-Hydroxyphenyl)thiazole-4-carbaldehyde
    • 2-(4-Hydroxy-phenyl)-thiazole-4-carbaldehyde
    • 2-(4-oxocyclohexa-2,5-dien-1-ylidene)-3H-1,3-thiazole-4-carbaldehyde
    • 4-Thiazolecarboxaldehyde,2-(4-hydroxyphenyl)-
    • 2-(4-Hydroxy-phenyl)-thiazole-4-carboxaldehyde
    • SCHEMBL21357610
    • 885278-87-5
    • MFCD06738378
    • AKOS015904344
    • FT-0739501
    • DTXSID10674291
    • AB27034
    • CS-0341906
    • 2-(4-Oxocyclohexa-2,5-dien-1-ylidene)-2,3-dihydro-1,3-thiazole-4-carbaldehyde
    • 2-(4-HYDROXYPHENYL)-1,3-THIAZOLE-4-CARBALDEHYDE
    • MDL： MFCD06738378
    • Inchi： 1S/C10H7NO2S/c12-5-8-6-14-10(11-8)7-1-3-9(13)4-2-7/h1-6,13H
    • InChI Key： HAXXZLBEEWCVAX-UHFFFAOYSA-N
    • SMILES： S1C=C(C=O)N=C1C1C=CC(=CC=1)O

Computed Properties

  • Exact Mass: 205.02000
  • Monoisotopic Mass: 205.01974964g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 14
  • Rotatable Bond Count: 2
  • Complexity: 398
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: 3
  • XLogP3: 1
  • Topological Polar Surface Area: 78.4?2

Experimental Properties

  • PSA: 78.43000
  • LogP: 2.32820

2-(4-Hydroxyphenyl)thiazole-4-carbaldehyde Customs Data

  • HS CODE：2934100090
  • Customs Data：

    China Customs Code:

    2934100090

    Overview:

    2934100090. Compounds that structurally contain a non fused thiazole ring(Whether hydrogenated or not). VAT:17.0%. Tax refund rate:9.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

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2-(4-Hydroxyphenyl)thiazole-4-carbaldehyde Related Literature

Additional information on 2-(4-Hydroxyphenyl)thiazole-4-carbaldehyde

Introduction to 2-(4-Hydroxyphenyl)thiazole-4-carbaldehyde (CAS No. 885278-87-5)

2-(4-Hydroxyphenyl)thiazole-4-carbaldehyde (CAS No. 885278-87-5) is a versatile organic compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound, characterized by its unique thiazole and hydroxyphenyl functionalities, exhibits a range of biological activities that make it a valuable candidate for various therapeutic applications.

The chemical structure of 2-(4-Hydroxyphenyl)thiazole-4-carbaldehyde consists of a thiazole ring attached to a 4-hydroxyphenyl group, with a carbonyl group at the 4-position of the thiazole ring. This structural arrangement imparts the compound with distinct chemical and physical properties, including solubility, stability, and reactivity. These properties are crucial for its potential use in drug development and other chemical applications.

Recent studies have highlighted the biological activities of 2-(4-Hydroxyphenyl)thiazole-4-carbaldehyde. One notable area of research is its antioxidant properties. Antioxidants play a critical role in neutralizing free radicals and preventing oxidative stress, which is implicated in various diseases such as cancer, cardiovascular diseases, and neurodegenerative disorders. In vitro studies have shown that 2-(4-Hydroxyphenyl)thiazole-4-carbaldehyde exhibits potent antioxidant activity, making it a promising candidate for further investigation in this context.

Another important aspect of 2-(4-Hydroxyphenyl)thiazole-4-carbaldehyde is its anti-inflammatory potential. Inflammation is a complex biological response to harmful stimuli and is a key factor in many chronic diseases. Research has demonstrated that 2-(4-Hydroxyphenyl)thiazole-4-carbaldehyde can modulate inflammatory pathways by inhibiting the production of pro-inflammatory cytokines and mediators. This property suggests its potential utility in treating inflammatory conditions such as arthritis and inflammatory bowel disease.

In addition to its antioxidant and anti-inflammatory activities, 2-(4-Hydroxyphenyl)thiazole-4-carbaldehyde has also been explored for its anticancer properties. Cancer remains one of the leading causes of mortality worldwide, and the development of new therapeutic agents is an ongoing challenge. Studies have shown that 2-(4-Hydroxyphenyl)thiazole-4-carbaldehyde can induce apoptosis (programmed cell death) in cancer cells while sparing normal cells. This selective cytotoxicity makes it an attractive candidate for cancer therapy.

The pharmacokinetic properties of 2-(4-Hydroxyphenyl)thiazole-4-carbaldehyde are also an important consideration in its potential therapeutic applications. Pharmacokinetics refers to how the body absorbs, distributes, metabolizes, and excretes a drug. Understanding these properties is crucial for optimizing dosing regimens and minimizing side effects. Preliminary studies suggest that 2-(4-Hydroxyphenyl)thiazole-4-carbaldehyde has favorable pharmacokinetic profiles, including good oral bioavailability and low toxicity.

Furthermore, the synthesis of 2-(4-Hydroxyphenyl)thiazole-4-carbaldehyde has been extensively studied to develop efficient and scalable methods for its production. Various synthetic routes have been reported, including multistep processes involving condensation reactions, cyclizations, and functional group transformations. These synthetic strategies are essential for ensuring the availability of high-purity material for research and development purposes.

In conclusion, 2-(4-Hydroxyphenyl)thiazole-4-carbaldehyde (CAS No. 885278-87-5) is a multifaceted compound with significant potential in medicinal chemistry and pharmaceutical research. Its unique chemical structure endows it with diverse biological activities, including antioxidant, anti-inflammatory, and anticancer properties. Ongoing research continues to uncover new applications and optimize its therapeutic potential, making it an exciting area of study for scientists and researchers worldwide.

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