Cas no 885278-83-1 (1-Cbz-3,5-dimethyl-piperazine)

1-Cbz-3,5-dimethyl-piperazine is a protected piperazine derivative featuring a carboxybenzyl (Cbz) group at the 1-position and methyl substituents at the 3- and 5-positions. This compound serves as a versatile intermediate in organic synthesis, particularly in pharmaceutical and peptide chemistry, where selective protection of the piperazine nitrogen is required. The Cbz group provides stability under basic conditions while allowing for facile deprotection under mild hydrogenolysis. The symmetrical dimethyl substitution enhances steric control in subsequent reactions, improving regioselectivity. Its well-defined structure and reactivity make it valuable for constructing complex heterocyclic frameworks or modifying bioactive molecules. The compound is typically handled under inert conditions due to the sensitivity of the Cbz protecting group.
1-Cbz-3,5-dimethyl-piperazine structure
1-Cbz-3,5-dimethyl-piperazine structure
Product Name:1-Cbz-3,5-dimethyl-piperazine
CAS No:885278-83-1
MF:C14H20N2O2
MW:248.320803642273
MDL:MFCD07371656
CID:993200
PubChem ID:23078633
Update Time:2025-06-08

1-Cbz-3,5-dimethyl-piperazine Chemical and Physical Properties

Names and Identifiers

    • Benzyl 3,5-dimethylpiperazine-1-carboxylate
    • Z-3,5-DIMETHYL-PIPERAZINE
    • 1-Cbz-3,5-dimethyl-piperazine
    • 1-Cbz-3,5-dimethylpiperazine
    • MFCD07371656
    • SCHEMBL4179954
    • SY098361
    • SB39529
    • (3R,5S)-Benzyl 3,5-dimethylpiperazine-1-carboxylate
    • SB22986
    • AS-35013
    • MFCD27988069
    • XYDSFNOXAYIVAR-UHFFFAOYSA-N
    • CS-0137179
    • AKOS022178132
    • 885278-83-1
    • cis-1-Cbz-3,5-dimethylpiperazine
    • SY039132
    • EN300-153574
    • (3S,5S)-1-Cbz-3,5-dimethylpiperazine
    • Z-3,5-DIMETHYL-PIPERAZINE,
    • rel-Benzyl (3R,5S)-3,5-dimethylpiperazine-1-carboxylate
    • BENZYL (3R,5S)-3,5-DIMETHYLPIPERAZINE-1-CARBOXYLATE
    • MDL： MFCD07371656
    • Inchi： 1S/C14H20N2O2/c1-11-8-16(9-12(2)15-11)14(17)18-10-13-6-4-3-5-7-13/h3-7,11-12,15H,8-10H2,1-2H3
    • InChI Key： XYDSFNOXAYIVAR-UHFFFAOYSA-N
    • SMILES： O(CC1C=CC=CC=1)C(N1CC(C)NC(C)C1)=O

Computed Properties

  • Exact Mass: 248.15200
  • Monoisotopic Mass: 248.152477885g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 18
  • Rotatable Bond Count: 4
  • Complexity: 267
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 2
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 1.8
  • Topological Polar Surface Area: 41.6?2

Experimental Properties

  • PSA: 41.57000
  • LogP: 2.27210

1-Cbz-3,5-dimethyl-piperazine Customs Data

  • HS CODE：2933599090
  • Customs Data：

    China Customs Code:

    2933599090

    Overview:

    2933599090. Other compounds with pyrimidine ring in structure(Including other compounds with piperazine ring on the structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1-Cbz-3,5-dimethyl-piperazine Pricemore >>

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Alichem
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JIE DA WEI （ SHANG HAI ） YI YAO KE JI FA ZHAN Co., Ltd.
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1-Cbz-3,5-dimethyl-piperazine
 885278-83-1 96%
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 10388.52CNY 2021-05-08
JIE DA WEI （ SHANG HAI ） YI YAO KE JI FA ZHAN Co., Ltd.
65R0064-500mg
1-Cbz-3,5-dimethyl-piperazine
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JIE DA WEI （ SHANG HAI ） YI YAO KE JI FA ZHAN Co., Ltd.
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