Cas no 885278-66-0 (2-(3-Amino-phenyl)-thiazole-4-carboxylic Acid ethyl ester)

2-(3-Amino-phenyl)-thiazole-4-carboxylic Acid ethyl ester is a versatile heterocyclic compound featuring both an amino-substituted phenyl ring and a thiazole carboxylic acid ethyl ester moiety. Its structural properties make it a valuable intermediate in organic synthesis, particularly in the development of pharmaceuticals and agrochemicals. The presence of the amino group allows for further functionalization, while the thiazole core contributes to its potential bioactivity. This compound exhibits good solubility in common organic solvents, facilitating its use in various reaction conditions. Its well-defined reactivity profile and stability under standard handling conditions make it a practical choice for research and industrial applications requiring precise molecular modifications.
2-(3-Amino-phenyl)-thiazole-4-carboxylic Acid ethyl ester structure
885278-66-0 structure
Product Name:2-(3-Amino-phenyl)-thiazole-4-carboxylic Acid ethyl ester
CAS No:885278-66-0
MF:C12H12N2O2S
MW:248.300881385803
MDL:MFCD06738349
CID:711583
PubChem ID:53403562
Update Time:2025-10-24

2-(3-Amino-phenyl)-thiazole-4-carboxylic Acid ethyl ester Chemical and Physical Properties

Names and Identifiers

    • 4-Thiazolecarboxylicacid, 2-(3-aminophenyl)-, ethyl ester
    • 2-(3-AMINO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
    • 2-(3-AMINOPHENYL)THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER,
    • ethyl 2-(3-aminophenyl)-1,3-thiazole-4-carboxylate
    • 2-(2,4,6-TRIMETHYL-BENZENESULFONYLAMINO)-BENZOIC ACID
    • ETHYL 2-(3-AMINOPHENYL)THIAZOLE-4-CARBOXYLATE
    • ETHYL2-(3-AMINOPHENYL)THIAZOLE-4-CARBOXYLATE
    • DTXSID00695192
    • AB26961
    • FT-0756184
    • 885278-66-0
    • AKOS015059508
    • MFCD06738349
    • CS-0340219
    • DB-077767
    • SY359628
    • 2-(3-Amino-phenyl)-thiazole-4-carboxylic Acid ethyl ester
    • MDL: MFCD06738349
    • Inchi: 1S/C12H12N2O2S/c1-2-16-12(15)10-7-17-11(14-10)8-4-3-5-9(13)6-8/h3-7H,2,13H2,1H3
    • InChI Key: IAWASZVWQFHEHX-UHFFFAOYSA-N
    • SMILES: S1C=C(C(=O)OCC)N=C1C1C=CC=C(C=1)N

Computed Properties

  • Exact Mass: 248.06200
  • Monoisotopic Mass: 248.06194880g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 17
  • Rotatable Bond Count: 4
  • Complexity: 275
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: 2.5
  • Topological Polar Surface Area: 93.4?2

Experimental Properties

  • PSA: 93.45000
  • LogP: 3.15020

2-(3-Amino-phenyl)-thiazole-4-carboxylic Acid ethyl ester Customs Data

  • HS CODE:2934100090
  • Customs Data:

    China Customs Code:

    2934100090

    Overview:

    2934100090. Compounds that structurally contain a non fused thiazole ring(Whether hydrogenated or not). VAT:17.0%. Tax refund rate:9.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

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2-(3-Amino-phenyl)-thiazole-4-carboxylic Acid ethyl ester Related Literature

Additional information on 2-(3-Amino-phenyl)-thiazole-4-carboxylic Acid ethyl ester

Comprehensive Overview of 2-(3-Amino-phenyl)-thiazole-4-carboxylic Acid ethyl ester (CAS No. 885278-66-0)

The compound 2-(3-Amino-phenyl)-thiazole-4-carboxylic Acid ethyl ester (CAS No. 885278-66-0) is a specialized organic molecule that has garnered significant attention in pharmaceutical and agrochemical research. With its unique thiazole core and ester functionality, this compound serves as a versatile intermediate in the synthesis of bioactive molecules. Researchers are particularly interested in its potential applications in drug discovery and material science, given its structural similarity to other heterocyclic compounds known for their biological activity.

In recent years, the demand for custom synthesis and high-purity intermediates like 2-(3-Amino-phenyl)-thiazole-4-carboxylic Acid ethyl ester has surged, driven by advancements in precision medicine and green chemistry. This compound’s amino-phenyl and thiazole moieties make it a promising candidate for targeting specific enzyme inhibitors or receptor modulators, aligning with current trends in personalized therapeutics. Its ethyl ester group further enhances solubility, a critical factor in formulation development.

From a synthetic chemistry perspective, CAS No. 885278-66-0 is often explored for its role in multicomponent reactions (MCRs) and catalyzed transformations. The rise of AI-driven molecular design has also highlighted its utility in virtual screening libraries, where researchers seek novel scaffolds for anti-inflammatory or antimicrobial agents. Questions like *"How to optimize the yield of 2-(3-Amino-phenyl)-thiazole-4-carboxylic Acid ethyl ester?"* or *"What are its stability conditions?"* are frequently searched in academic and industrial forums.

Environmental and regulatory considerations are equally pivotal. The compound’s low toxicity profile (as per available data) and compatibility with sustainable solvents resonate with the global push toward eco-friendly synthesis. Laboratories prioritizing REACH compliance or green metrics often evaluate this ester derivative for its minimal waste generation during production. Such attributes make it a subject of interest in patent literature and industrial white papers.

In summary, 2-(3-Amino-phenyl)-thiazole-4-carboxylic Acid ethyl ester exemplifies the intersection of innovative chemistry and applied research. Its adaptability across life sciences and material engineering ensures its relevance in addressing contemporary challenges, from drug resistance to functional material design. As synthetic methodologies evolve, this compound is poised to remain a cornerstone in high-value chemical development.

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