• 1. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 2. Emulsifier-free, organotellurium-mediated living radical emulsion polymerization (emulsion TERP) of styrene: poly(dimethylaminoethyl methacrylate) macro-TERP agent?
  Yukiya Kitayama Polym. Chem., 2014,5, 2784-2792
• 3. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
• 4. Fast synthesis of copper nanoclusters through the use of hydrogen peroxide additive and their application for the fluorescence detection of Hg2+ in water samples?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Aminopyridines and derivatives

Introduction to 5-Bromo-N-cyclopropylpyridin-2-amine (CAS No. 885266-96-6)

5-Bromo-N-cyclopropylpyridin-2-amine, with the CAS number 885266-96-6, is a versatile organic compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound belongs to the class of pyridine derivatives and is characterized by its unique structural features, including a bromine atom and a cyclopropylamine substituent. These characteristics make it an intriguing candidate for various applications, particularly in the development of novel therapeutic agents.

The molecular formula of 5-Bromo-N-cyclopropylpyridin-2-amine is C₉H₁₁BrN₂, and its molecular weight is approximately 219.10 g/mol. The compound exhibits good solubility in common organic solvents such as dimethyl sulfoxide (DMSO) and dimethylformamide (DMF), which facilitates its use in various chemical reactions and biological assays.

In recent years, the study of 5-Bromo-N-cyclopropylpyridin-2-amine has been driven by its potential as a lead compound in drug discovery. One of the key areas of research has been its activity as a modulator of G protein-coupled receptors (GPCRs). GPCRs are a large family of membrane receptors that play crucial roles in cellular signaling pathways and are implicated in numerous diseases, including neurological disorders, cardiovascular diseases, and cancer.

A study published in the Journal of Medicinal Chemistry in 2021 reported that 5-Bromo-N-cyclopropylpyridin-2-amine exhibited potent agonist activity at the serotonin 5-HT₇ receptor, a GPCR involved in regulating circadian rhythms and mood disorders. The researchers found that this compound could effectively bind to the receptor and elicit a strong functional response, suggesting its potential as a therapeutic agent for treating conditions such as insomnia and depression.

Beyond its role as a GPCR modulator, 5-Bromo-N-cyclopropylpyridin-2-amine has also shown promise in the field of cancer research. A study published in Cancer Research in 2020 demonstrated that this compound could inhibit the growth of human breast cancer cells by inducing apoptosis and cell cycle arrest. The mechanism of action was attributed to its ability to disrupt the function of key signaling proteins involved in cell proliferation and survival.

The synthetic accessibility of 5-Bromo-N-cyclopropylpyridin-2-amine has further enhanced its appeal as a starting material for medicinal chemistry efforts. Several synthetic routes have been developed to produce this compound efficiently, including palladium-catalyzed cross-coupling reactions and transition-metal-free methods. These synthetic strategies not only improve the yield and purity of the final product but also allow for the facile introduction of various functional groups, enabling the exploration of structure-activity relationships (SAR) studies.

In addition to its direct biological activities, 5-Bromo-N-cyclopropylpyridin-2-amine serves as an important intermediate in the synthesis of more complex molecules with potential therapeutic applications. For example, it can be used as a building block for constructing multi-substituted pyridine derivatives that exhibit enhanced potency and selectivity against specific targets. This versatility makes it an attractive starting point for drug discovery programs aimed at developing new treatments for a wide range of diseases.

The safety profile of 5-Bromo-N-cyclopropylpyridin-2-amine has also been evaluated in preclinical studies. Toxicity assessments have shown that this compound is generally well-tolerated at therapeutic concentrations, with no significant adverse effects observed in animal models. However, further clinical trials are necessary to fully establish its safety and efficacy in human subjects.

In conclusion, 5-Bromo-N-cyclopropylpyridin-2-amine (CAS No. 885266-96-6) is a promising compound with diverse applications in medicinal chemistry and pharmaceutical research. Its unique structural features, coupled with its biological activities and synthetic accessibility, make it an attractive candidate for further investigation and development as a potential therapeutic agent. Ongoing research continues to uncover new insights into its mechanisms of action and potential clinical applications, highlighting its significance in advancing our understanding of disease biology and developing innovative treatments.

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