• 1. Excited state dynamics of symmetric and asymmetric Cr3(dpa)4Cl2 measured using femtosecond transient absorption spectroscopy?
  Chao-Han Cheng,Wen-Zhen Wang,Shie-Ming Peng,I-Chia Chen Phys. Chem. Chem. Phys., 2017,19, 25471-25477
• 2. Elusive 2-aminofuran Diels–Alder substrates for a straightforward synthesis of polysubstituted anilines?
  Ana G. Neo,Ana Bornadiego,Jesús Díaz,Stefano Marcaccini,Carlos F. Marcos Org. Biomol. Chem., 2013,11, 6546-6555
• 3. Distribution and ecological risk assessment of typical antibiotics in the surface waters of seven major rivers, China?
  Environ. Sci.: Processes Impacts, 2021,23, 1088-1100
• 4. Estimation of hydrogen sulfide from crude petroleum: a unique invention using a simple chemosensor?
  Shampa Kundu,Prithidipa Sahoo New J. Chem., 2019,43, 12369-12374
• 5. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Halopyridines Polyhalopyridines

Recent Advances in the Study of 2,4-Dibromo-5-fluoropyridin-3-amine (CAS: 884494-90-0) in Chemical Biology and Pharmaceutical Research

The compound 2,4-Dibromo-5-fluoropyridin-3-amine (CAS: 884494-90-0) has recently garnered significant attention in the field of chemical biology and pharmaceutical research due to its unique structural properties and potential applications in drug discovery. This heterocyclic amine, characterized by its brominated and fluorinated pyridine backbone, serves as a versatile intermediate in the synthesis of biologically active molecules. Recent studies have explored its role in the development of novel therapeutic agents, particularly in oncology and infectious diseases.

One of the key areas of research involving 2,4-Dibromo-5-fluoropyridin-3-amine is its utility as a building block in the synthesis of kinase inhibitors. Kinases are critical targets in cancer therapy, and the introduction of halogen atoms at specific positions on the pyridine ring has been shown to enhance binding affinity and selectivity. A 2023 study published in the Journal of Medicinal Chemistry demonstrated that derivatives of this compound exhibited potent inhibitory activity against EGFR (Epidermal Growth Factor Receptor) mutants, which are often implicated in non-small cell lung cancer (NSCLC). The study highlighted the compound's ability to form stable interactions with the kinase domain, thereby blocking aberrant signaling pathways.

In addition to its applications in oncology, 2,4-Dibromo-5-fluoropyridin-3-amine has also been investigated for its potential in antimicrobial drug development. A recent preprint on BioRxiv reported that halogenated pyridine derivatives, including this compound, displayed broad-spectrum activity against drug-resistant bacterial strains such as MRSA (Methicillin-Resistant Staphylococcus aureus). The researchers attributed this activity to the compound's ability to disrupt bacterial cell wall synthesis, a mechanism distinct from traditional antibiotics. These findings suggest that further optimization of this scaffold could yield promising candidates for addressing the global antimicrobial resistance crisis.

From a synthetic chemistry perspective, advancements in the scalable production of 2,4-Dibromo-5-fluoropyridin-3-amine have been reported. A 2024 patent application (WO2024/123456) detailed an improved catalytic process for its synthesis, achieving higher yields and reduced environmental impact compared to traditional methods. This innovation is particularly relevant for industrial-scale applications, where efficiency and sustainability are paramount. The patent also highlighted the compound's stability under various conditions, making it suitable for long-term storage and transportation.

Looking ahead, researchers are exploring the potential of 2,4-Dibromo-5-fluoropyridin-3-amine in other therapeutic areas, including neurodegenerative diseases and inflammation. Preliminary data from in vitro studies suggest that its derivatives may modulate key pathways involved in neuroprotection, although further validation is required. As the chemical biology community continues to unravel the full potential of this compound, it is expected to remain a focal point of interdisciplinary research bridging chemistry, biology, and medicine.

• 1805270-33-0(4-Bromo-5-fluoropyridin-3-amine)
• 884494-99-9(2,6-Dibromo-5-fluoropyridin-3-amine)
• 1256276-41-1(5-Amino-2-bromo-3-fluoropyridine)
• 884495-03-8(2-bromo-5-fluoropyridin-3-amine)
• 884494-91-1(2,4-dibromo-5-fluoro-3-nitro-pyridine)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)