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• 2. Excellent lithium ion storage property of porous MnCo2O4 nanorods?
  Peiyuan Zeng,Xiaoxiao Wang,Ming Ye,Qiuyang Ma,Jianwen Li,Wanwan Wang,Baoyou Geng,Zhen Fang RSC Adv., 2016,6, 23074-23084
• 3. Evolutionary de novo design of phenothiazine derivatives for dye-sensitized solar cells?
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers Phenol ethers
• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers

Professional Introduction to 2-Fluoro-4-propoxy-benzaldehyde (CAS No. 883543-14-4)

2-Fluoro-4-propoxy-benzaldehyde, with the chemical identifier CAS No. 883543-14-4, is a specialized organic compound that has garnered significant attention in the field of pharmaceutical chemistry and synthetic biology. This compound belongs to the class of aromatic aldehydes, characterized by the presence of a benzene ring substituted with a fluoro group at the 2-position and a propoxy group at the 4-position. The unique structural features of 2-Fluoro-4-propoxy-benzaldehyde make it a valuable intermediate in the synthesis of various bioactive molecules, particularly in the development of novel therapeutic agents.

The significance of this compound lies in its versatility as a building block for more complex structures. In recent years, there has been a surge in research focused on fluorinated aromatic compounds due to their enhanced metabolic stability, improved binding affinity, and altered pharmacokinetic properties compared to their non-fluorinated counterparts. The introduction of fluorine atoms into aromatic rings can significantly influence the electronic properties and reactivity of these molecules, making them highly desirable for medicinal chemists.

2-Fluoro-4-propoxy-benzaldehyde has been extensively explored in the synthesis of small-molecule drugs targeting various diseases. One notable area of research is its application in the development of kinase inhibitors, which are crucial for treating cancers and inflammatory diseases. The fluoro group at the 2-position enhances the lipophilicity of the molecule, facilitating better cell membrane penetration, while the propoxy group contributes to metabolic stability. These features make 2-Fluoro-4-propoxy-benzaldehyde an excellent candidate for further derivatization into potent and selective kinase inhibitors.

In addition to its role in kinase inhibition, 2-Fluoro-4-propoxy-benzaldehyde has also been utilized in the synthesis of antiviral and antibacterial agents. The structural motif present in this compound allows for easy modification at multiple positions, enabling the creation of libraries of compounds with diverse biological activities. Recent studies have demonstrated its utility in generating novel scaffolds that exhibit inhibitory effects against viral proteases and bacterial enzymes, highlighting its potential as a lead compound in drug discovery.

The synthetic pathways involving 2-Fluoro-4-propoxy-benzaldehyde are another area of active investigation. Researchers have developed efficient methodologies for introducing fluorine and propyl groups onto aromatic rings, leveraging palladium-catalyzed cross-coupling reactions and nucleophilic aromatic substitutions. These techniques not only provide access to 2-Fluoro-4-propoxy-benzaldehyde but also enable the preparation of structurally related compounds with tailored properties. Such advancements in synthetic chemistry are crucial for accelerating the discovery and development of new therapeutic agents.

The pharmacological profile of derivatives derived from 2-Fluoro-4-propoxy-benzaldehyde has been thoroughly examined in preclinical studies. These studies have revealed promising results regarding their efficacy and safety profiles. For instance, certain derivatives have shown potent activity against specific disease targets while maintaining good tolerability in animal models. This underscores the importance of 2-Fluoro-4-propoxy-benzaldehyde as a starting material for generating lead compounds with therapeutic potential.

The future directions for research involving 2-Fluoro-4-propoxy-benzaldehyde are multifaceted. One area involves expanding its applications into other therapeutic areas such as neurodegenerative diseases and metabolic disorders. The unique structural features of this compound make it an attractive candidate for designing molecules that can interact with specific biological targets involved in these conditions. Additionally, there is growing interest in exploring its role in drug delivery systems, where fluorinated compounds can enhance stability and bioavailability.

In conclusion, 2-Fluoro-4-propoxy-benzaldehyde (CAS No. 883543-14-4) represents a significant advancement in pharmaceutical chemistry due to its versatile applications and structural features. Its role as an intermediate in synthesizing bioactive molecules has been well-documented, particularly in the development of kinase inhibitors, antiviral agents, and antibacterial compounds. The ongoing research into its synthetic pathways and pharmacological properties continues to uncover new possibilities for its use in drug discovery and development.

• 477982-20-0
• 456-99-5(Benzaldehyde,2-fluoro-4-(4-methoxyphenoxy)-)
• 141080-74-2(2-[(18)F]-fluoro-4-methoxybenzaldehyde)
• 891842-42-5(Benzaldehyde, 5-ethoxy-2-fluoro-)
• 532965-74-5(4-Ethoxy-2-fluorobenzaldehyde)
• 331-64-6(2-Fluoro-4-methoxybenzaldehyde)
• 256417-10-4(2,6-Difluoro-4-methoxybenzaldehyde)
• 82129-45-1(BENZALDEHYDE, 2-ETHOXY-6-FLUORO-)
• 1373920-93-4(4-Butoxy-2,6-difluorobenzaldehyde)
• 1017779-48-4(4-Ethoxy-2,6-difluorobenzaldehyde)