• 1. Emerging investigator series: first-principles and thermodynamics comparison of compositionally-tuned delafossites: cation release from the (001) surface of complex metal oxides?
  Joseph W. Bennett,Diamond T. Jones,Blake G. Hudson,Joshua Melendez-Rivera,Robert J. Hamers,Sara E. Mason Environ. Sci.: Nano, 2020,7, 1642-1651
• 2. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
  Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182
• 3. Emulsion technologies for multicellular tumour spheroid radiation assays?
  Kay S. McMillan,Anthony G. McCluskey,Annette Sorensen,Marie Boyd,Michele Zagnoni Analyst, 2016,141, 100-110
• 4. Emulsion soft templating of carbide-derived carbon nanospheres with controllable porosity for capacitive electrochemical energy storage?
  M. Zeiger,N. J?ckel,P. Strubel,L. Borchardt,R. Reinhold,W. Nickel,J. Eckert,V. Presser,S. Kaskel J. Mater. Chem. A, 2015,3, 17983-17990
• 5. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
  Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Isoxazoles

Isoxazole, 5-(trichloromethyl)- (CAS No. 88283-10-7): A Comprehensive Overview of Its Applications and Recent Research Developments

The compound Isoxazole, 5-(trichloromethyl)- (CAS No. 88283-10-7) is a heterocyclic organic molecule that has garnered significant attention in the field of pharmaceutical and chemical research due to its unique structural properties and potential biological activities. This introduction provides a detailed exploration of the compound, its chemical characteristics, synthetic pathways, and most notably, its applications in contemporary scientific studies.

Isoxazole is a five-membered aromatic ring consisting of three carbon atoms and two oxygen atoms. The presence of a trichloromethyl substituent at the 5-position introduces electrophilic characteristics to the molecule, making it a versatile intermediate in organic synthesis. The CAS number 88283-10-7 uniquely identifies this specific isoxazole derivative, distinguishing it from other isoxazole compounds with different substituents or structural modifications.

The synthesis of Isoxazole, 5-(trichloromethyl)- typically involves multi-step reactions starting from readily available precursors such as chloroacetonitrile and malononitrile. The process often includes cyclization reactions that form the isoxazole core, followed by functional group transformations to introduce the trichloromethyl group. Advanced synthetic techniques, including catalytic hydrogenation and metal-catalyzed cross-coupling reactions, have been employed to optimize yield and purity.

In recent years, Isoxazole, 5-(trichloromethyl)- has been extensively studied for its potential pharmacological properties. Its structural motif is found in several bioactive natural products and drug candidates, suggesting that it may exhibit similar therapeutic effects. Preliminary in vitro studies have indicated that this compound demonstrates inhibitory activity against various enzymes and receptors relevant to inflammatory diseases and cancer.

One of the most promising areas of research involving Isoxazole, 5-(trichloromethyl)- is its application as a scaffold for developing novel antiviral agents. The unique electronic distribution within the isoxazole ring allows for interactions with viral proteases and polymerases, potentially inhibiting viral replication. Recent studies have shown that derivatives of this compound can disrupt the life cycle of certain RNA viruses by targeting critical enzymatic steps.

The compound's reactivity also makes it valuable in materials science applications. For instance, researchers have explored its use in designing advanced polymers with enhanced thermal stability and mechanical strength. The incorporation of the trichloromethyl group into polymer backbones improves cross-linking efficiency, leading to materials with improved durability under harsh conditions.

Eco-friendly synthetic routes for producing Isoxazole, 5-(trichloromethyl)- have also been developed as part of broader efforts to minimize environmental impact. Green chemistry principles have guided the optimization of synthetic pathways to reduce waste generation and energy consumption. For example, solvent-free reactions and microwave-assisted synthesis have been successfully implemented to achieve high yields while maintaining sustainability.

The pharmacokinetic properties of this compound are another focus of ongoing research. Studies have investigated how variations in dosage and administration routes affect its bioavailability and metabolic pathways. Understanding these parameters is crucial for translating preclinical findings into effective therapeutic strategies for human diseases.

In conclusion, Isoxazole, 5-(trichloromethyl)- (CAS No. 88283-10-7) represents a fascinating molecule with diverse applications spanning pharmaceuticals, materials science, and environmental chemistry. Its unique structural features offer opportunities for developing innovative solutions to complex scientific challenges. As research continues to uncover new possibilities for this compound, its significance in advancing both academic knowledge and industrial applications is likely to grow even further.

• 135351-33-6(Isoxazole, 3-methyl-5-(trichloromethyl)-)
• 27930-43-4(Isoxazole, 5-(dichloromethyl)-3-methyl-)
• 57777-33-0(5-(chloromethyl)-1,2-oxazole)
• 169888-53-3(Isoxazole,5-(dichloromethyl)-)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)