Cas no 88234-77-9 (7-methoxy-1-benzofuran-2-carbaldehyde)

7-Methoxy-1-benzofuran-2-carbaldehyde is a heterocyclic aromatic compound featuring a benzofuran core substituted with a methoxy group at the 7-position and a formyl group at the 2-position. This structure imparts reactivity suitable for further functionalization, making it a valuable intermediate in organic synthesis, particularly in the development of pharmaceuticals, agrochemicals, and fine chemicals. The methoxy group enhances electron density, influencing the compound's reactivity in electrophilic substitution and cross-coupling reactions. Its aldehyde functionality allows for condensation, reduction, or nucleophilic addition, offering versatility in constructing complex molecular frameworks. The compound is characterized by high purity and stability, ensuring consistent performance in synthetic applications.
7-methoxy-1-benzofuran-2-carbaldehyde structure
88234-77-9 structure
Product Name:7-methoxy-1-benzofuran-2-carbaldehyde
CAS No:88234-77-9
MF:C10H8O3
MW:176.168723106384
MDL:MFCD03984484
CID:723501
PubChem ID:3457310
Update Time:2025-10-19

7-methoxy-1-benzofuran-2-carbaldehyde Chemical and Physical Properties

Names and Identifiers

    • 7-Methoxybenzofuran-2-carbaldehyde
    • 2-Benzofurancarboxaldehyde,7-methoxy-
    • 7-methoxy-2-Benzofurancarboxaldehyde
    • 7-METHOXY-BENZOFURAN-2-CARBALDEHYDE
    • 7-methoxy-1-benzofuran-2-carbaldehyde
    • 2-Formyl-7-methoxybenzofuran
    • ZVPJQWBKNUJXSY-UHFFFAOYSA-N
    • AKOS000116467
    • FT-0705948
    • Z56914847
    • 7-methoxy-benzofuran-2-carbaldehyde, AldrichCPR
    • EN300-05536
    • 88234-77-9
    • DTXSID70392661
    • SCHEMBL118870
    • MDL: MFCD03984484
    • Inchi: 1S/C10H8O3/c1-12-9-4-2-3-7-5-8(6-11)13-10(7)9/h2-6H,1H3
    • InChI Key: ZVPJQWBKNUJXSY-UHFFFAOYSA-N
    • SMILES: O1C(C=O)=CC2C=CC=C(C1=2)OC

Computed Properties

  • Exact Mass: 176.047
  • Monoisotopic Mass: 176.047
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 13
  • Rotatable Bond Count: 2
  • Complexity: 193
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 2.1
  • Topological Polar Surface Area: 39.4?2

Experimental Properties

  • Density: 1.24
  • Boiling Point: 296°C at 760 mmHg
  • Flash Point: 132.8°C
  • Refractive Index: 1.619
  • PSA: 39.44000
  • LogP: 2.25390

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Additional information on 7-methoxy-1-benzofuran-2-carbaldehyde

Comprehensive Overview of 7-Methoxy-1-benzofuran-2-carbaldehyde (CAS No. 88234-77-9): Properties, Applications, and Research Insights

7-Methoxy-1-benzofuran-2-carbaldehyde (CAS No. 88234-77-9) is a specialized organic compound belonging to the benzofuran family, characterized by its unique methoxy and aldehyde functional groups. This compound has garnered significant attention in pharmaceutical and material science research due to its versatile chemical structure. With a molecular formula of C10H8O3, it serves as a key intermediate in synthesizing bioactive molecules, including potential antioxidants and anti-inflammatory agents, aligning with current trends in drug discovery and green chemistry.

Recent studies highlight the role of 7-methoxy-1-benzofuran-2-carbaldehyde in flavor and fragrance applications, where its aromatic properties are exploited for creating complex olfactory profiles. Researchers are also exploring its utility in organic electronics, particularly in designing light-emitting diodes (LEDs) and photovoltaic materials, addressing the growing demand for sustainable energy solutions. The compound’s low toxicity and biodegradability further enhance its appeal in eco-conscious industries.

From a synthetic perspective, CAS No. 88234-77-9 is often derived via Vilsmeier-Haack formylation or oxidative coupling reactions, methodologies frequently searched in academic databases. Its crystallographic data and spectroscopic properties (e.g., NMR and IR spectra) are well-documented, making it a reference compound for analytical chemists. The rise of AI-driven molecular modeling has further propelled interest in predicting its reactivity and optimizing synthesis routes, a topic trending in computational chemistry forums.

In the context of consumer safety, regulatory bodies classify 7-methoxy-1-benzofuran-2-carbaldehyde as non-hazardous under standard handling conditions, though proper laboratory protocols are recommended. Its compatibility with green solvents like ethanol and water aligns with the global shift toward sustainable manufacturing, a frequently searched term in industrial chemistry circles. Additionally, its stability under ambient conditions makes it a practical choice for long-term storage.

Future research directions for 88234-77-9 may focus on its potential in nanotechnology and bioconjugation, areas gaining traction in multidisciplinary studies. As the scientific community prioritizes carbon-neutral processes, this compound’s derivatization pathways could contribute to circular economy initiatives. For those seeking high-purity samples, reputable suppliers often provide GC-MS and HPLC certifications, ensuring compliance with ISO standards.

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