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Comprehensive Overview of 1-(2-Methoxy-4-pyridinyl)-1-Propanone (CAS No. 880767-50-0): Properties, Applications, and Industry Insights

1-(2-Methoxy-4-pyridinyl)-1-Propanone (CAS No. 880767-50-0) is a specialized organic compound that has garnered significant attention in pharmaceutical and agrochemical research due to its unique structural features. This ketone derivative incorporates a methoxy-substituted pyridine ring, which enhances its reactivity and makes it a valuable intermediate in synthetic chemistry. Researchers frequently search for "synthesis of 1-(2-methoxy-4-pyridinyl)-1-propanone" or "CAS 880767-50-0 applications," reflecting its growing importance in drug discovery pipelines.

The compound's molecular structure (C9H11NO2) combines a propanone backbone with a 2-methoxy-4-pyridinyl group, creating distinct electronic properties that influence its behavior in coupling reactions. Recent studies highlight its role in developing kinase inhibitors, a hot topic in oncology research, as evidenced by rising searches for "pyridine-based drug intermediates 2024." Its moderate polarity (logP ~1.2) and melting point range (78-82°C) make it suitable for diverse reaction conditions, addressing common queries like "solubility of CAS 880767-50-0" in academic forums.

In the context of green chemistry trends, 1-(2-Methoxy-4-pyridinyl)-1-Propanone has been explored in catalytic hydrogenation processes, aligning with industry demands for sustainable synthesis methods. Patent analyses reveal its utility in creating heterocyclic scaffolds for crop protection agents, responding to searches for "agrochemical intermediates with pyridine moieties." The compound's stability under acidic conditions (pH 2-6) further expands its applicability, a feature often questioned in "880767-50-0 stability studies" discussions.

Quality control protocols for CAS 880767-50-0 emphasize HPLC purity (>98%) and spectroscopic characterization (IR: 1685 cm?1 for C=O stretch; 1H NMR δ 8.2 ppm for pyridinyl protons), addressing laboratory professionals' queries about "analytical methods for ketone derivatives." Its compatibility with Pd-catalyzed cross-coupling reactions positions it as a key player in fragment-based drug design, coinciding with rising interest in "small molecule building blocks for drug discovery."

Market intelligence indicates growing demand for 1-(2-Methoxy-4-pyridinyl)-1-Propanone in Asia-Pacific research hubs, particularly for neurodegenerative disease research – a trending search term in 2024. The compound's low ecotoxicity profile (OECD 301D) makes it preferable over halogenated analogs, reflecting environmental concerns captured in queries like "green alternatives to halogenated ketones." Storage recommendations (2-8°C under inert atmosphere) and handling precautions are frequently discussed in technical datasheets, addressing safety-related searches.

Innovative applications include its use as a fluorescence quencher in material science, responding to nanotechnology trends. The methoxy group's directing effects in electrophilic substitutions make it valuable for regioselective functionalization, a concept often explored in "pyridine derivative reactivity" tutorials. Recent publications (2023-2024) describe its incorporation into photoactive polymers, linking to renewable energy research – another high-traffic topic in scientific databases.

For synthetic chemists, the compound's crystallization behavior (orthorhombic system) and scalable production routes are practical considerations, matching search patterns like "process optimization for CAS 880767-50-0." Its role in multi-component reactions demonstrates versatility, while regulatory compliance (REACH registered) ensures global accessibility – factors increasingly important in procurement decisions as seen in "EU-compliant chemical suppliers" search volumes.

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