• 1. Enabling stable MnO2 matrix for aqueous zinc-ion battery cathodes?
  Yiding Jiao,Liqun Kang,Jasper Berry-Gair,Kit McColl,Jianwei Li,Haobo Dong,Hao Jiang,Ryan Wang,Furio Corà,Dan J. L. Brett,Ivan P. Parkin J. Mater. Chem. A, 2020,8, 22075-22082
• 2. Excitable dynamics in the bromate–sulfite–ferrocyanide reaction
  J. Zagora,M. Vosla?,L. Schreiberová,I. Schreiber Phys. Chem. Chem. Phys., 2002,4, 1284-1291
• 3. Exceptionally high temperature spin crossover in amide-functionalised 2,6-bis(pyrazol-1-yl)pyridine iron(ii) complex revealed by variable temperature Raman spectroscopy and single crystal X-ray diffraction?
  Max Attwood,Hiroki Akutsu,Lee Martin,Toby J. Blundell,Pierre Le Maguere,Scott S. Turner Dalton Trans., 2021,50, 11843-11851
• 4. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
• 5. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylcarbamic acid esters

(3-Bromo-4-methyl-phenyl)methylcarbamic Acid tert-Butyl Ester (CAS No. 877064-95-4)

The compound (3-Bromo-4-methyl-phenyl)methylcarbamic Acid tert-Butyl Ester, identified by the CAS registry number 877064-95-4, is a versatile organic compound with significant applications in various fields of chemistry. This compound belongs to the class of carbamates, which are widely used as intermediates in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. The structure of this compound comprises a phenyl ring substituted with bromine and methyl groups, along with a carbamate functional group attached to a tert-butyl ester moiety. This unique combination of functional groups makes it highly reactive and suitable for a range of chemical transformations.

Recent advancements in synthetic chemistry have highlighted the importance of (3-Bromo-4-methyl-phenyl)methylcarbamic Acid tert-Butyl Ester as a key intermediate in the construction of bioactive molecules. For instance, researchers have employed this compound in the synthesis of novel kinase inhibitors, which hold promise in the treatment of various cancers. The bromine substituent on the phenyl ring plays a crucial role in modulating the electronic properties of the molecule, thereby enhancing its binding affinity to target proteins. Additionally, the tert-butyl ester group provides excellent leaving group properties, facilitating various substitution reactions during the synthesis process.

In terms of synthesis, this compound can be prepared via a multi-step process involving nucleophilic aromatic substitution and esterification reactions. The starting material is typically a bromo-substituted aniline derivative, which undergoes alkylation to introduce the methylcarbamate group. Subsequent esterification with tert-butanol yields the final product. The reaction conditions, such as temperature and solvent choice, are critical in ensuring high yields and purity of the product.

The application of (3-Bromo-4-methyl-phenyl)methylcarbamic Acid tert-Butyl Ester extends beyond pharmaceuticals. It has also been utilized in the development of advanced materials, such as high-performance polymers and coatings. The carbamate group imparts hydrophilic properties to the molecule, making it suitable for applications requiring water solubility or improved adhesion characteristics.

From an environmental perspective, recent studies have focused on the biodegradation pathways of this compound. Researchers have found that under aerobic conditions, the tert-butyl ester group undergoes hydrolysis to form carboxylic acids, which are further metabolized by microorganisms. This information is crucial for assessing the environmental impact and designing sustainable synthetic routes for this compound.

In conclusion, (3-Bromo-4-methyl-phenyl)methylcarbamic Acid tert-Butyl Ester (CAS No. 877064-95-4) is a valuable compound with diverse applications in chemistry and materials science. Its unique structure and reactivity make it an essential building block for synthesizing bioactive molecules and advanced materials. As research continues to uncover new applications and improve synthetic methodologies, this compound will undoubtedly remain a cornerstone in modern chemical synthesis.

• 197144-27-7(Carbamic acid, bis(4-bromophenyl)-, 1,1-dimethylethyl ester)
• 57598-34-2(Tert-Butyl 3-Bromophenyl(Methyl)Carbamate)
• 25216-74-4(tert-Butyl N-(3-Bromophenyl)carbamate)
• 515813-02-2((3-Bromo-4-methyl-phenyl)carbamic Acid tert-Butyl Ester)
• 654056-82-3(N-BOC-4-bromo-3-methylaniline)
• 1405128-28-0(Tert-butyl N-(3-bromo-5-methylphenyl)carbamate)
• 221538-03-0(tert-Butyl 3-Bromo-2-methylphenylcarbamate)
• 361436-27-3(N-Boc 4-bromo-3,5-dimethylaniline)
• 639520-70-0(N-Boc 4-Bromo-N-methylaniline)
• 1644434-36-5(Carbamic acid, N-[4-[2-(2-bromophenyl)ethynyl]phenyl]-N-methyl-, 1,1-dimethylethyl ester)