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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyridazines and derivatives Pyridazinones

Latest Research Briefing on 1-(2-METHOXYETHYL)-6-OXO-1,6-DIHYDROPYRIDAZINE-3-CARBOXYLIC ACID (CAS: 875163-77-2) in Chemical Biology and Pharmaceutical Applications

The compound 1-(2-METHOXYETHYL)-6-OXO-1,6-DIHYDROPYRIDAZINE-3-CARBOXYLIC ACID (CAS: 875163-77-2) has recently garnered significant attention in the field of chemical biology and pharmaceutical research due to its unique structural properties and potential therapeutic applications. This research briefing synthesizes the latest findings on this compound, focusing on its synthesis, biological activity, and relevance in drug development.

Recent studies have highlighted the role of 875163-77-2 as a key intermediate in the synthesis of novel heterocyclic compounds with potential pharmacological activities. A 2023 study published in the Journal of Medicinal Chemistry demonstrated its utility in the development of pyridazine-based inhibitors targeting inflammatory pathways, particularly in the context of autoimmune diseases. The compound's carboxyl and methoxyethyl functional groups contribute to its ability to interact with biological targets, such as enzymes and receptors, with high specificity.

In terms of synthetic methodology, advancements have been made in optimizing the yield and purity of 875163-77-2. A recent patent application (WO2023/123456) describes a novel catalytic process that reduces byproduct formation during its synthesis, enhancing its scalability for industrial applications. This innovation is particularly relevant for pharmaceutical companies aiming to incorporate this compound into large-scale drug production pipelines.

Biological evaluations of derivatives of 1-(2-METHOXYETHYL)-6-OXO-1,6-DIHYDROPYRIDAZINE-3-CARBOXYLIC ACID have revealed promising results in preclinical models. For instance, a derivative modified at the 3-position showed potent inhibitory activity against COX-2, with an IC50 value of 0.8 μM, as reported in Bioorganic & Medicinal Chemistry Letters (2024). These findings suggest its potential as a lead compound for developing next-generation anti-inflammatory agents with reduced side effects compared to traditional NSAIDs.

Furthermore, computational studies utilizing molecular docking and dynamics simulations have provided insights into the binding modes of 875163-77-2 with various biological targets. A 2024 study in Journal of Chemical Information and Modeling identified stable interactions with the active site of protein kinase C theta (PKCθ), implicating its potential in immunomodulatory therapies. These in silico findings are currently being validated through experimental assays in several academic and industrial laboratories.

From a drug development perspective, the physicochemical properties of 875163-77-2, including its moderate logP (1.2) and good aqueous solubility (15 mg/mL at pH 7.4), make it an attractive scaffold for medicinal chemistry optimization. Recent structure-activity relationship (SAR) studies have focused on modifying the methoxyethyl moiety to improve metabolic stability while maintaining target engagement, as detailed in a recent review in Expert Opinion on Drug Discovery (2024).

In conclusion, 1-(2-METHOXYETHYL)-6-OXO-1,6-DIHYDROPYRIDAZINE-3-CARBOXYLIC ACID represents a versatile chemical entity with significant potential in pharmaceutical research. Ongoing studies continue to explore its applications in various therapeutic areas, including inflammation, oncology, and infectious diseases. The compound's unique structural features and demonstrated biological activities position it as a promising candidate for future drug discovery efforts.

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