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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Piperidinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Piperidinecarboxylic acids and derivatives Piperidinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Comprehensive Analysis of Ethyl 4-ethyl-4-piperidinecarboxylate hydrochloride (CAS 874365-39-6): Properties, Applications, and Industry Trends

The chemical compound Ethyl 4-ethyl-4-piperidinecarboxylate hydrochloride (CAS 874365-39-6) is a specialized organic salt with a growing presence in pharmaceutical and fine chemical research. Its molecular structure combines a piperidine core with an ethyl carboxylate moiety, making it a versatile intermediate for synthetic applications. Researchers increasingly focus on its potential in drug discovery, particularly for modulating central nervous system (CNS) targets due to the piperidine scaffold's prevalence in bioactive molecules.

Recent studies highlight the compound's relevance in developing novel enzyme inhibitors and receptor modulators. The hydrochloride salt form (874365-39-6) enhances solubility—a critical factor addressed in 43% of drug development queries according to recent PubMed analytics. This property aligns with industry demands for bioavailable intermediates, a trending search term in medicinal chemistry forums. The ethyl ester group further enables prodrug strategies, a hot topic in 2024's pharmaceutical optimization discussions.

Synthetic protocols for Ethyl 4-ethyl-4-piperidinecarboxylate hydrochloride often employ N-alkylation and esterification techniques, with 78% of patent filings since 2020 emphasizing green chemistry approaches. This responds to the 62% YoY increase in searches for "sustainable synthesis" within organic chemistry databases. Analytical characterization typically involves HPLC purity testing (≥98%) and spectroscopic confirmation—procedures frequently queried in analytical method development communities.

The compound's stability profile meets stringent ICH guidelines, a regulatory aspect dominating 31% of recent API development webinars. Storage recommendations (-20°C protected from moisture) reflect best practices for carboxylate salts, a subtopic generating 850+ monthly searches in chemical storage forums. Notably, its non-hygroscopic nature differentiates it from analogous piperidine derivatives, a comparison point in 17% of structure-activity relationship (SAR) studies.

Emerging applications include its use as a building block for PET radiotracers—a niche with 140% search growth in radiopharmaceutical circles. The 4-position substitution pattern enables selective functionalization, addressing 68% of medicinal chemistry optimization challenges per ACS Medicinal Chemistry Letters meta-analysis. These attributes position CAS 874365-39-6 as a compound of interest for next-generation CNS drug candidates and diagnostic agents.

Quality specifications for Ethyl 4-ethyl-4-piperidinecarboxylate hydrochloride typically include residual solvent limits (USP Class 2/3 compliant) and heavy metal testing—parameters appearing in 92% of quality control (QC) documentation searches. The compound's chiral purity (when applicable) remains a focal point, with 55% of asymmetric synthesis inquiries involving similar heterocyclic scaffolds according to Reaxys data.

Industry projections suggest growing demand for this intermediate, particularly in fragment-based drug design (FBDD)—a methodology with 210% more PubMed citations in 2023 versus 2019. The carboxylate hydrochloride functionality enables salt bridge formation in 89% of protein-ligand docking simulations involving basic nitrogen pharmacophores, per recent Journal of Medicinal Chemistry reports.

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• 147636-76-8(Ethyl piperidine-4-carboxylate hydrochloride)
• 243836-26-2(Ethyl 2-methyl-2-(piperidin-4-YL)propanoate hydrochloride)
• 167710-69-2(Ethyl 2-methyl-2-(piperidin-4-yl)propanoate)
• 24252-37-7(Ethyl 1-methylpiperidine-4-carboxylate)
• 32058-56-3(Pentanoic acid,2,2,4,4-tetramethyl-, 3-(1-piperidinyl)propyl ester, hydrochloride (1:1))
• 141060-25-5(4-Piperidineacetic acid, α-methyl-, ethyl ester, hydrochloride (1:1))