Cas no 86938-17-2 (Boc-Glu-OEt·DCHA)

Boc-Glu-OEt·DCHA is a protected derivative of glutamic acid, where the α-amino group is shielded by a tert-butoxycarbonyl (Boc) group and the γ-carboxyl group is esterified as an ethyl ester (OEt). The inclusion of dicyclohexylamine (DCHA) forms a stable salt, enhancing the compound's crystallinity and handling properties. This reagent is widely used in peptide synthesis, particularly for introducing glutamic acid residues while minimizing side reactions. The Boc group allows selective deprotection under mild acidic conditions, while the ethyl ester offers additional stability during synthesis. Its high purity and consistent performance make it a reliable choice for solid-phase and solution-phase peptide chemistry.
Boc-Glu-OEt·DCHA structure
Boc-Glu-OEt·DCHA structure
Product Name:Boc-Glu-OEt·DCHA
CAS No:86938-17-2
MF:C12H21NO6
MW:275.2982442379
MDL:MFCD08702734
CID:706805
PubChem ID:13819298
Update Time:2025-06-13

Boc-Glu-OEt·DCHA Chemical and Physical Properties

Names and Identifiers

    • (S)-4-((tert-Butoxycarbonyl)amino)-5-ethoxy-5-oxopentanoic acid
    • Boc-glu-oet
    • Boc-Glu-OEt · DCHA
    • BOC-GLU-OET DCHA
    • L-Glutamicacid, N-[(1,1-dimethylethoxy)carbonyl]-, 1-ethyl ester
    • (4S)-4-[(tert-Butoxycarbonyl)amino]-5-ethoxy-5-oxopentanoic acid (non-preferred name)
    • (S)-4-((tert-Butoxycarbonyl)amino)-5-ethoxy-5-oxopentanoicacid
    • EN300-12447357
    • LXQBXYDPJVHNPQ-QMMMGPOBSA-N
    • (4S)-4-{[(tert-butoxy)carbonyl]amino}-5-ethoxy-5-oxopentanoic acid
    • 86938-17-2
    • SCHEMBL2301394
    • (S)-2-tert-butoxycarbonylamino-pentanedioic acid 1-ethyl ester
    • DTXSID30550487
    • (4S)-4-[(TERT-BUTOXYCARBONYL)AMINO]-5-ETHOXY-5-OXOPENTANOIC ACID
    • (4S)-5-ethoxy-4-[(2-methylpropan-2-yl)oxycarbonylamino]-5-oxopentanoic acid
    • Boc-Glu-OEt·DCHA
    • MDL： MFCD08702734
    • Inchi： 1S/C12H21NO6/c1-5-18-10(16)8(6-7-9(14)15)13-11(17)19-12(2,3)4/h8H,5-7H2,1-4H3,(H,13,17)(H,14,15)/t8-/m0/s1
    • InChI Key： LXQBXYDPJVHNPQ-QMMMGPOBSA-N
    • SMILES： O(C(N[C@H](C(=O)OCC)CCC(=O)O)=O)C(C)(C)C

Computed Properties

  • Exact Mass: 275.13688739g/mol
  • Monoisotopic Mass: 275.13688739g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 3
  • Hydrogen Bond Acceptor Count: 8
  • Heavy Atom Count: 32
  • Rotatable Bond Count: 12
  • Complexity: 334
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 1
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 1.1
  • Topological Polar Surface Area: 102?2

Boc-Glu-OEt·DCHA Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
Chemenu
CM194752-5g
(S)-4-((tert-butoxycarbonyl)amino)-5-ethoxy-5-oxopentanoic acid
 86938-17-2 97%
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Enamine
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 86938-17-2 95.0%
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Enamine
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(4S)-4-{[(tert-butoxy)carbonyl]amino}-5-ethoxy-5-oxopentanoic acid
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Enamine
EN300-12447357-250mg
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Enamine
EN300-12447357-500mg
(4S)-4-{[(tert-butoxy)carbonyl]amino}-5-ethoxy-5-oxopentanoic acid
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 $271.0 2023-10-02
Enamine
EN300-12447357-1000mg
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 86938-17-2 95.0%
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Boc-Glu-OEt·DCHA Related Literature

Related Categories

Additional information on Boc-Glu-OEt·DCHA

Comprehensive Overview of Boc-Glu-OEt·DCHA (CAS No. 86938-17-2): Properties, Applications, and Industry Insights

Boc-Glu-OEt·DCHA (CAS No. 86938-17-2) is a protected derivative of glutamic acid, widely utilized in peptide synthesis and pharmaceutical research. This compound features a tert-butoxycarbonyl (Boc) protecting group, an ethyl ester (-OEt), and a dicyclohexylamine (DCHA) salt form, enhancing its stability and solubility for laboratory applications. Its molecular structure and functional groups make it a critical intermediate in the production of bioactive peptides, drug candidates, and specialty chemicals.

In recent years, the demand for Boc-Glu-OEt·DCHA has surged due to its role in solid-phase peptide synthesis (SPPS), a technique pivotal for developing therapeutics targeting metabolic disorders, neurodegenerative diseases, and oncology. Researchers frequently search for "Boc-Glu-OEt·DCHA solubility" or "Boc-Glu-OEt·DCHA synthesis protocol," reflecting its technical relevance. The compound’s compatibility with Fmoc/Boc strategies and its low racemization risk further elevate its utility in high-precision applications.

From a commercial perspective, Boc-Glu-OEt·DCHA is often sourced for GMP-grade peptide manufacturing, aligning with stringent regulatory standards. Industry trends highlight growing interest in "sustainable peptide synthesis" and "green chemistry alternatives," prompting suppliers to optimize production processes for this compound. Its high purity (>98%) and consistent performance under anhydrous conditions are key selling points for vendors.

Analytical techniques such as HPLC, NMR, and mass spectrometry are routinely employed to verify the integrity of Boc-Glu-OEt·DCHA. FAQs like "How to store Boc-Glu-OEt·DCHA?" (recommended: 2–8°C under inert gas) or "Boc-Glu-OEt·DCHA vs. Boc-Glu-OH" underscore user concerns about stability and reactivity. The compound’s DCHA counterion also facilitates crystallization, simplifying purification steps.

Emerging applications include its use in linker chemistry for antibody-drug conjugates (ADCs) and protease-resistant peptide design, areas gaining traction in biopharmaceutical R&D. As peptide-based drugs dominate clinical pipelines, Boc-Glu-OEt·DCHA remains a cornerstone for innovators exploring next-generation therapeutics. Its adaptability to automated synthesizers further future-proofs its industrial relevance.

In summary, Boc-Glu-OEt·DCHA (CAS No. 86938-17-2) exemplifies the synergy between chemical innovation and biomedical advancement. With robust demand drivers and evolving applications, it continues to attract academic and commercial attention worldwide.

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