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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Phenylpyridines

Comprehensive Overview of 2-Pyridinecarbonitrile, 3-(2-fluorophenyl)- (CAS No. 868944-81-4)

2-Pyridinecarbonitrile, 3-(2-fluorophenyl)- (CAS No. 868944-81-4) is a specialized organic compound that has garnered significant attention in pharmaceutical and agrochemical research. This compound, characterized by its pyridine core and fluorophenyl substitution, is a key intermediate in the synthesis of bioactive molecules. Its unique structural features make it a valuable building block for drug discovery, particularly in the development of kinase inhibitors and other therapeutic agents targeting chronic diseases.

The growing interest in 3-(2-fluorophenyl)-2-pyridinecarbonitrile is driven by its potential applications in precision medicine and small-molecule drug design. Researchers are increasingly exploring its utility in modulating protein-protein interactions, a hot topic in cancer therapy and neurodegenerative disease research. The compound's fluorine moiety enhances its metabolic stability, a property highly sought after in modern pharmacokinetic optimization strategies.

From a synthetic chemistry perspective, CAS 868944-81-4 represents an interesting case study in heterocyclic compound formation. The cyano group at the 2-position of the pyridine ring offers versatile reactivity for further derivatization, while the 2-fluorophenyl substituent contributes to the compound's overall electronic properties. These characteristics make it particularly valuable for structure-activity relationship (SAR) studies in medicinal chemistry programs.

The compound's relevance extends to green chemistry initiatives, as researchers investigate more sustainable routes for its synthesis. Recent publications have highlighted innovative catalytic methods for constructing the pyridine-fluorophenyl scaffold with improved atom economy and reduced waste generation. This aligns with the pharmaceutical industry's growing emphasis on environmentally friendly synthesis and process intensification.

Analytical characterization of 2-Pyridinecarbonitrile, 3-(2-fluorophenyl)- typically involves advanced techniques such as NMR spectroscopy, mass spectrometry, and X-ray crystallography. These methods confirm the compound's structural integrity and purity, which are critical parameters for its use in high-throughput screening and lead compound development. The fluorine atom's distinct NMR signature provides a convenient handle for reaction monitoring and quality control.

In the context of drug discovery trends, this compound fits well with current interests in fragment-based drug design and covalent inhibitor development. Its moderate molecular weight and balanced physicochemical properties make it an attractive starting point for hit-to-lead optimization campaigns. Several recent patent applications have featured derivatives of 3-(2-fluorophenyl)-2-pyridinecarbonitrile as potential therapeutics for inflammatory disorders and metabolic diseases.

The commercial availability of CAS 868944-81-4 has expanded in recent years to meet growing demand from contract research organizations and academic laboratories. Suppliers now offer the compound in various quantities, from milligram-scale for initial screening to kilogram quantities for process development. This accessibility has accelerated research into its potential applications across multiple therapeutic areas.

From a regulatory standpoint, proper handling and storage of 2-Pyridinecarbonitrile, 3-(2-fluorophenyl)- follow standard laboratory safety protocols. While not classified as hazardous under normal conditions, researchers should employ appropriate personal protective equipment when working with this compound, consistent with good laboratory practices for all chemical substances.

Future research directions for this compound likely include exploration of its bioconjugation potential and investigation of its photophysical properties for possible applications in diagnostic imaging. The combination of its aromatic system and fluorine atom makes it an interesting candidate for development as a molecular probe or PET tracer precursor.

In summary, 2-Pyridinecarbonitrile, 3-(2-fluorophenyl)- (CAS No. 868944-81-4) represents a versatile and valuable compound in modern chemical research. Its unique structural features and multiple points for chemical modification ensure its continued relevance in medicinal chemistry and material science applications. As synthetic methodologies advance and biological screening technologies become more sophisticated, this compound is poised to play an increasingly important role in the development of next-generation therapeutic agents.

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