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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Benzoic acids

Comprehensive Overview of 2-Morpholin-4-ylmethyl-benzoic acid (CAS No. 868543-19-5): Properties, Applications, and Research Insights

2-Morpholin-4-ylmethyl-benzoic acid (CAS No. 868543-19-5) is a specialized organic compound that has garnered significant attention in pharmaceutical and chemical research due to its unique structural features and potential applications. This benzoic acid derivative, characterized by the presence of a morpholine ring, serves as a versatile intermediate in synthetic chemistry. Its molecular formula, C₁₂H₁₅NO₃, and molecular weight of 221.25 g/mol make it a valuable building block for drug discovery and material science.

The compound's morpholinomethyl substitution at the 2-position of the benzoic acid scaffold enhances its solubility and bioavailability, making it a preferred choice for researchers exploring bioactive molecules. Recent studies highlight its role in designing kinase inhibitors and anti-inflammatory agents, aligning with current trends in targeted therapy development. The CAS No. 868543-19-5 is frequently searched in databases like SciFinder and Reaxys, reflecting its relevance in academic and industrial settings.

From a synthetic perspective, 2-Morpholin-4-ylmethyl-benzoic acid is synthesized via nucleophilic substitution reactions between morpholine and halogenated benzoic acid derivatives. Its crystalline form and stability under ambient conditions facilitate handling in laboratory environments. Analytical techniques such as HPLC, NMR, and mass spectrometry are commonly employed to verify its purity, which is critical for high-yield downstream applications.

In the context of green chemistry, researchers are investigating eco-friendly synthesis routes for CAS No. 868543-19-5 to minimize waste and energy consumption. This aligns with global initiatives like the UN Sustainable Development Goals (SDGs), particularly Goal 12 (Responsible Consumption and Production). The compound's potential in biodegradable polymer formulations is another emerging area of interest, addressing the demand for sustainable materials.

Frequently asked questions about 2-Morpholin-4-ylmethyl-benzoic acid include its storage conditions (recommended: 2–8°C in airtight containers), solubility profile (soluble in DMSO, methanol, and slightly in water), and safety data (non-hazardous under standard handling protocols). These details are crucial for laboratories optimizing its use in multi-step syntheses.

Market analyses indicate growing demand for 868543-19-5 in Asia-Pacific regions, driven by expanding pharmaceutical R&D activities. Patent filings related to this compound often cite its utility in cancer therapeutics and neuroprotective agents, reflecting its interdisciplinary importance. Collaborative studies between academia and industry continue to uncover novel derivatives with enhanced efficacy.

In summary, 2-Morpholin-4-ylmethyl-benzoic acid exemplifies how structural modifications of simple aromatic acids can yield compounds with broad scientific utility. Its integration into high-throughput screening libraries and combinatorial chemistry workflows underscores its enduring relevance. Future research may explore its role in AI-driven drug design platforms, merging computational and experimental approaches for accelerated discovery.

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