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  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
• 2. An atomically efficient, highly stable and redox active Ce0.5Tb0.5Ox (3% mol.)/MgO catalyst for total oxidation of methane?
  Juan J. Sánchez,Miguel López-Haro,Juan C. Hernández-Garrido,Ginesa Blanco,Miguel A. Cauqui,José M. Rodríguez-Izquierdo,José A. Pérez-Omil,José J. Calvino,María P. Yeste J. Mater. Chem. A, 2019,7, 8993-9003
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Halobenzenes Iodobenzenes

1-Bromo-2-fluoro-4-iodo-5-methylbenzene (CAS No 861928-20-3)

1-Bromo-2-fluoro-4-iodo-5-methylbenzene, also known by its CAS registry number 861928-20-3, is a highly specialized aromatic compound with a unique substitution pattern. This compound belongs to the class of polyhalogenated benzenes, which have garnered significant attention in various fields due to their versatile chemical properties. The molecule features a bromine atom at position 1, a fluorine atom at position 2, an iodine atom at position 4, and a methyl group at position 5 on the benzene ring. This specific arrangement of substituents imparts distinctive electronic and steric effects, making it valuable for advanced chemical applications.

The synthesis of 1-bromo-2-fluoro-4-iodo-5-methylbenzene typically involves multi-step organic reactions, often employing electrophilic substitution strategies. Recent advancements in catalytic methods have enabled more efficient and selective syntheses, reducing byproducts and enhancing yield. For instance, researchers have explored the use of palladium-catalyzed coupling reactions to introduce halogen atoms at specific positions on the benzene ring. These methods are not only environmentally friendly but also align with the growing demand for sustainable chemical processes.

One of the most promising applications of this compound lies in its use as an intermediate in pharmaceutical chemistry. The presence of multiple halogen atoms allows for further functionalization, enabling the construction of complex molecular frameworks. For example, recent studies have demonstrated its utility in synthesizing bioactive molecules with potential anticancer properties. The methyl group at position 5 serves as a site for additional modifications, such as alkylation or acylation, further expanding its versatility.

In materials science, 1-bromo-2-fluoro-4-iodo-5-methylbenzene has been investigated as a precursor for advanced materials like organic semiconductors and light-emitting diodes (LEDs). Its electronic properties, influenced by the electron-withdrawing effects of bromine and fluorine atoms, make it suitable for applications requiring precise control over charge transport mechanisms. Recent research has highlighted its potential in developing high-efficiency OLEDs with improved color purity and operational stability.

The physical properties of this compound are equally noteworthy. It exhibits a high melting point due to strong intermolecular forces arising from the halogen atoms. Its solubility in organic solvents is moderate, making it amenable to solution-phase reactions. The compound is stable under normal conditions but requires protection from moisture and light to prevent degradation.

In terms of safety considerations, while handling 1-bromo-2-fluoro-4-iodo-5-methylbenzene, appropriate personal protective equipment should be used to minimize exposure risks. Although it is not classified as a hazardous substance under standard conditions, prolonged or excessive exposure may cause irritation to the eyes and skin.

The demand for this compound has been steadily increasing due to its role in cutting-edge research and industrial applications. Its inclusion in various chemical libraries has facilitated its use in high-throughput screening processes for drug discovery. Furthermore, its compatibility with modern analytical techniques such as NMR spectroscopy and mass spectrometry enhances its utility in structural elucidation studies.

In conclusion, 1-bromo-2-fluoro-4-iodo-5-methylbenzene (CAS No 861928-20) stands out as a valuable compound with diverse applications across multiple disciplines. Its unique substitution pattern, combined with advancements in synthetic methodologies and application-oriented research, positions it as an essential building block in contemporary chemical innovation.

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