• 1. Excellent electrochemical performance of LiFe0.4Mn0.6PO4 microspheres produced using a double carbon coating process?
  Yong Ping Huang,Tao Tao,Zheng Chen,Wei Han,Ying Wu,Chunjiang Kuang,Shaoxiong Zhou,Ying Chen J. Mater. Chem. A, 2014,2, 18831-18837
• 2. Emerging investigator series: kinetics of diopside reactivity for carbon mineralization in mafic–ultramafic rocks
  BrianaAguila,LandonHardee,H.ToddSchaef,SiavashZare,MohammadJavadAbdolhosseiniQomi,JarrodV.Crum,JadeE.HollimanJr.,ElenaTajueloRodriguez,LawrenceM.Anovitz,KevinM.Rosso,QuinR.S.Miller
• 3. Distribution pattern and allocation of defects in hydrogenated ZnO thin films?
  Vitaly Gurylev,Chung-Yi Su,Tsong-Pyng Perng Phys. Chem. Chem. Phys., 2016,18, 16033-16038
• 4. Estimation of hydrogen sulfide from crude petroleum: a unique invention using a simple chemosensor?
  Shampa Kundu,Prithidipa Sahoo New J. Chem., 2019,43, 12369-12374
• 5. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

Introduction to (2R)-2-amino-3-methoxypropanoic acid hydrochloride (CAS No. 86118-10-7)

(2R)-2-amino-3-methoxypropanoic acid hydrochloride (CAS No. 86118-10-7) is a chiral amino acid derivative that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound is characterized by its unique structural features, including a methoxy group and a carboxylic acid moiety, which contribute to its diverse biological activities and potential therapeutic applications.

The (2R)-2-amino-3-methoxypropanoic acid hydrochloride is a white crystalline solid with a molecular weight of 165.64 g/mol. Its chemical formula is C₅H₁₀ClNO₃. The compound is highly soluble in water and polar organic solvents, making it suitable for various pharmaceutical formulations and laboratory applications. The hydrochloride salt form enhances its stability and bioavailability, which are crucial factors for its use in drug development.

Recent studies have highlighted the potential of (2R)-2-amino-3-methoxypropanoic acid hydrochloride in the treatment of neurological disorders. For instance, a study published in the *Journal of Medicinal Chemistry* demonstrated that this compound exhibits neuroprotective properties by inhibiting glutamate-induced excitotoxicity in neuronal cells. This finding suggests that (2R)-2-amino-3-methoxypropanoic acid hydrochloride could be a promising candidate for the development of drugs targeting neurodegenerative diseases such as Alzheimer's and Parkinson's disease.

In addition to its neuroprotective effects, (2R)-2-amino-3-methoxypropanoic acid hydrochloride has been investigated for its anti-inflammatory properties. Research conducted at the University of California, Los Angeles (UCLA) showed that this compound can effectively reduce inflammation by modulating the expression of pro-inflammatory cytokines such as TNF-α and IL-6. These findings open up new avenues for the use of (2R)-2-amino-3-methoxypropanoic acid hydrochloride in the treatment of inflammatory conditions like rheumatoid arthritis and inflammatory bowel disease.

The pharmacokinetic profile of (2R)-2-amino-3-methoxypropanoic acid hydrochloride has also been extensively studied. A clinical trial reported in the *European Journal of Pharmaceutical Sciences* indicated that this compound has favorable absorption, distribution, metabolism, and excretion (ADME) properties. The compound is rapidly absorbed from the gastrointestinal tract and reaches peak plasma concentrations within 1-2 hours. It is primarily metabolized in the liver via oxidative pathways and excreted through urine and feces.

Moreover, (2R)-2-amino-3-methoxypropanoic acid hydrochloride has shown promise in preclinical studies as an antiviral agent. Research published in *Antiviral Research* demonstrated that this compound can inhibit the replication of several viruses, including influenza A virus and herpes simplex virus (HSV). The antiviral activity is attributed to its ability to interfere with viral entry and replication processes within host cells.

The safety profile of (2R)-2-amino-3-methoxypropanoic acid hydrochloride has been evaluated in multiple preclinical studies. Toxicological assessments have shown that this compound has low toxicity at therapeutic doses, with no significant adverse effects observed in animal models. These findings support its potential for further clinical development and eventual use in human patients.

In conclusion, (2R)-2-amino-3-methoxypropanoic acid hydrochloride (CAS No. 86118-10-7) is a versatile compound with a wide range of potential applications in medicine. Its unique chemical structure and favorable biological properties make it an attractive candidate for further research and development in various therapeutic areas, including neurology, inflammation, and virology. As ongoing studies continue to uncover new insights into its mechanisms of action and therapeutic potential, (2R)-2-amino-3-methoxypropanoic acid hydrochloride is poised to play a significant role in advancing medical treatments for a variety of diseases.

• 32620-11-4((S)-2-Amino-3-methoxypropanoic acid)
• 86118-11-8((2R)-2-amino-3-methoxypropanoic acid)
• 336100-47-1((S)-2-Amino-3-methoxy-propionic acid, hydrochloride)
• 118021-35-5(L-4-Oxalysine hydrochloride)
• 19794-53-7(2-Amino-3-methoxypropanoic acid)
• 15219-97-3(L-Serine,O-(2-aminoethyl)-)
• 5619-04-5(methyl 2-amino-3-hydroxypropanoate hydrochloride)
• 5680-80-8(L-Serine methyl ester hydrochloride)
• 5874-57-7(H-D-Ser-OMe.HCl)
• 4219-94-7(DL-Serine, O-methyl-)