• 1. An inter-tangled network of redox-active and conducting polymers as a cathode for ultrafast rechargeable batteries
  Jieun Kim,Han-Saem Park,Tae-Hee Kim,Sung Yeol Kim,Hyun-Kon Song Phys. Chem. Chem. Phys., 2014,16, 5295-5300
• 2. An air-stable organometallic polymer containing titanafluorene moieties obtained by the Sonogashira–Hagihara cross-coupling polycondensation?
  Alvin Tanudjaja,Shinsuke Inagi,Fusao Kitamura,Toshikazu Takata,Ikuyoshi Tomita Dalton Trans., 2021,50, 3037-3043
• 3. An amide probe as a selective Al3+ and Fe3+ sensor inside the HeLa and a549 cell lines: Pictet–Spengler reaction for the rapid detection of tryptophan amino acid?
  Bidyut Kumar Kundu,Rinky Singh,Ritudhwaj Tiwari,Debasis Nayak New J. Chem., 2019,43, 4867-4877
• 4. An alumina stabilized graphene oxide wrapped SnO2 hollow sphere LIB anode with improved lithium storage?
  Xiang Liu,Qian Sun,A. B. Djuri?i?,Maohai Xie,Baohu Dai,Jinyao Tang,Charles Surya,Changzhong Liao,Kaimin Shih RSC Adv., 2015,5, 100783-100789
• 5. An intermolecular C–C coupling reaction of iridium complexes?
  Kathrin Kutlescha,Rhett Kempe New J. Chem., 2010,34, 1954-1960

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzoxazoles Benzoxazoles
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzoxazoles

Introduction to 2-Benzoxazolamine, N-2-propyn-1-yl- (CAS No. 85902-42-7)

2-Benzoxazolamine, N-2-propyn-1-yl-, identified by its Chemical Abstracts Service (CAS) number 85902-42-7, is a specialized organic compound that has garnered significant attention in the field of pharmaceutical chemistry and bioorganic synthesis. This compound belongs to the benzoxazole class, a heterocyclic structure known for its broad spectrum of biological activities. The presence of an alkyne functional group at the 2-position and an amine substituent at the nitrogen atom introduces unique reactivity and potential applications in medicinal chemistry.

The molecular structure of 2-Benzoxazolamine, N-2-propyn-1-yl- consists of a benzene ring fused with an oxygen-containing heterocycle (oxazole), with an amine group (-NH?) attached to the nitrogen atom of the oxazole ring. The propynyl group (-C≡CH) appended to the benzene ring enhances its chemical versatility, making it a valuable intermediate in the synthesis of more complex molecules. This structural motif has been explored in various research avenues, particularly in the development of novel pharmacophores targeting neurological and inflammatory disorders.

In recent years, there has been a surge in interest regarding benzoxazole derivatives due to their demonstrated efficacy as bioactive agents. The amine functionality in 2-Benzoxazolamine, N-2-propyn-1-yl- allows for further derivatization through condensation reactions, leading to the formation of Schiff bases and other nitrogen-containing heterocycles. These derivatives have shown promise in inhibiting enzymes such as cyclooxygenase (COX) and lipoxygenase (LOX), which are pivotal in mediating inflammatory responses.

One of the most compelling aspects of 2-Benzoxazolamine, N-2-propyn-1-yl- is its potential as a scaffold for drug discovery. Researchers have leveraged its structural framework to design molecules with enhanced binding affinity and selectivity towards specific biological targets. For instance, modifications at the propynyl group have been investigated for optimizing pharmacokinetic properties, including solubility and metabolic stability. Such efforts align with the growing emphasis on structure-based drug design, where computational modeling plays a crucial role in predicting molecular interactions.

The alkyne moiety in 2-Benzoxazolamine, N-2-propyn-1-yl- also facilitates cross-coupling reactions, such as Suzuki-Miyaura and Sonogashira couplings, which are widely employed in constructing biaryl systems. These reactions are particularly useful in generating complex aromatic structures that mimic natural products or known bioactive compounds. The ability to introduce diverse substituents at the 2-position via these transformations makes this compound a versatile building block for medicinal chemists.

Recent advancements in synthetic methodologies have further expanded the utility of 2-Benzoxazolamine, N-2-propyn-1-yl-. For example, transition-metal-catalyzed reactions have enabled efficient functionalization of the propynyl group, allowing for the introduction of additional pharmacophoric elements. Such innovations have accelerated the discovery pipeline for novel therapeutic agents, particularly those targeting chronic diseases characterized by complex pathophysiology.

The pharmacological profile of derivatives derived from 2-Benzoxazolamine, N-2-propyn-1-yl- has been extensively studied in preclinical models. Initial findings suggest that certain analogs exhibit potent anti-inflammatory and analgesic effects without significant side effects. These properties make them attractive candidates for further development into clinical candidates. Additionally, the compound's ability to modulate neurotransmitter systems has sparked interest in its potential application as an adjunct therapy for neurological disorders.

In conclusion, 2-Benzoxazolamine,N- propyn_-¹y, CAS No. 85902-42-7, represents a promising entity in pharmaceutical research due to its structural versatility and biological relevance. Ongoing studies continue to uncover new synthetic pathways and pharmacological applications, reinforcing its importance as a key intermediate in drug discovery efforts aimed at addressing unmet medical needs.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)