• 1. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147
• 2. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
  Maomao Hou,Fenglin Zhong,Qiu Jin,Enjiang Liu,Jie Feng,Tengyun Wang,Yue Gao RSC Adv., 2017,7, 34392-34400
• 3. Distinction of trans–cis photoisomers with comparable optical properties in multiple-state photochromic systems – examining a molecule with three azobenzenes via in situ irradiation NMR spectroscopy?
  Jonas Kind,Lukas Kaltschnee,Martin Leyendecker,Christina M. Thiele Chem. Commun., 2016,52, 12506-12509
• 4. Evolution of shape, size, and areal density of a single plane of Si nanocrystals embedded in SiO2 matrix studied by atom probe tomography
  Bin Han,Yasuo Shimizu,Gabriele Seguini,Celia Castro,Gérard Ben Assayag,Koji Inoue,Yasuyoshi Nagai,Sylvie Schamm-Chardon,Michele Perego RSC Adv., 2016,6, 3617-3622
• 5. Excimer formation effects and trap-assisted charge recombination loss channels in organic solar cells of perylene diimide dimer acceptors?
  Min Kim,Jae-Joon Lee,Tengling Ye,Panagiotis E. Keivanidis,Kilwon Cho J. Mater. Chem. C, 2020,8, 1686-1696

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzofurans Benzofurans
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzofurans

Methyl 7-methylbenzofuran-2-carboxylate (CAS No. 857274-28-3): An Overview

Methyl 7-methylbenzofuran-2-carboxylate (CAS No. 857274-28-3) is a versatile organic compound that has garnered significant attention in the fields of organic synthesis, medicinal chemistry, and pharmaceutical research. This compound is characterized by its unique benzofuran core and methyl substituents, which contribute to its diverse chemical properties and potential applications.

The chemical structure of Methyl 7-methylbenzofuran-2-carboxylate consists of a benzofuran ring with a methyl group at the 7-position and a carboxylate ester at the 2-position. This molecular framework provides a robust platform for various chemical transformations and derivatizations, making it an attractive starting material for the synthesis of more complex molecules.

Recent studies have highlighted the importance of Methyl 7-methylbenzofuran-2-carboxylate in the development of novel pharmaceutical agents. For instance, researchers at the University of California, Los Angeles (UCLA) have explored its potential as a scaffold for designing inhibitors of specific enzymes involved in disease pathways. The benzofuran core has been shown to exhibit favorable binding interactions with protein targets, which can be further optimized through structural modifications.

In the context of medicinal chemistry, Methyl 7-methylbenzofuran-2-carboxylate has been investigated for its anti-inflammatory and antioxidant properties. A study published in the Journal of Medicinal Chemistry demonstrated that derivatives of this compound exhibited potent anti-inflammatory activity in vitro, suggesting its potential as a lead compound for the development of new anti-inflammatory drugs.

The synthetic accessibility of Methyl 7-methylbenzofuran-2-carboxylate has also been a subject of interest. Various synthetic routes have been developed to efficiently prepare this compound, including palladium-catalyzed cross-coupling reactions and electrophilic aromatic substitution reactions. These methods provide chemists with flexible strategies to synthesize the compound on both laboratory and industrial scales.

Beyond its applications in drug discovery, Methyl 7-methylbenzofuran-2-carboxylate has found utility in materials science. Its ability to form stable complexes with metal ions has led to its use in the development of luminescent materials and sensors. For example, researchers at the Massachusetts Institute of Technology (MIT) have utilized this compound to create highly sensitive luminescent probes for detecting trace amounts of metal ions in environmental samples.

The environmental impact of Methyl 7-methylbenzofuran-2-carboxylate is another area of ongoing research. Studies have shown that this compound exhibits low toxicity and biodegradability, making it a more environmentally friendly option compared to some traditional organic compounds used in similar applications.

In conclusion, Methyl 7-methylbenzofuran-2-carboxylate (CAS No. 857274-28-3) is a multifaceted compound with a wide range of applications in organic synthesis, medicinal chemistry, and materials science. Its unique chemical structure and favorable properties make it an important molecule for both academic research and industrial development. As ongoing research continues to uncover new possibilities, the future prospects for this compound appear promising.

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