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Comprehensive Guide to O-(2-Iodobenzyl)hydroxylamine hydrochloride (CAS 854382-33-5): Properties, Applications, and Research Insights

O-(2-Iodobenzyl)hydroxylamine hydrochloride (CAS 854382-33-5) is a specialized organic compound widely recognized in pharmaceutical research and chemical synthesis. This compound, featuring an iodobenzyl group and a hydroxylamine moiety, serves as a versatile building block for drug discovery and bioconjugation. Its unique structure enables applications in proteomics, biomarker development, and medicinal chemistry, making it a focal point for researchers exploring targeted therapies and small-molecule inhibitors.

The growing interest in O-(2-Iodobenzyl)hydroxylamine hydrochloride aligns with trends in precision medicine and AI-driven drug design. Searches for "hydroxylamine derivatives in cancer research" or "iodobenzyl compounds for bioconjugation" highlight its relevance. Researchers frequently inquire about its solubility, stability, and reaction mechanisms, particularly in click chemistry and protein labeling. Its CAS number 854382-33-5 is often used to track purity and supplier data, reflecting stringent quality demands in high-throughput screening.

From a synthetic chemistry perspective, this compound’s iodo-substituted aromatic ring facilitates cross-coupling reactions, such as Suzuki-Miyaura or Sonogashira reactions. Its hydroxylamine hydrochloride group is pivotal for forming oxime linkages, a strategy leveraged in antibody-drug conjugates (ADCs). Recent publications emphasize its role in developing PET radiotracers and fluorescent probes, addressing needs in diagnostic imaging and cellular tracking.

Environmental and handling considerations for O-(2-Iodobenzyl)hydroxylamine hydrochloride are also trending topics. Users often search for "safe storage of hydroxylamine salts" or "compatibility with common solvents." The compound’s crystalline powder form requires protection from moisture and light, with recommendations for desiccated storage at controlled temperatures. These protocols ensure optimal performance in long-term studies.

Innovations in green chemistry have spurred interest in optimizing its synthesis. Queries like "eco-friendly routes to iodobenzyl compounds" reflect this shift. Advances in catalytic methods and microwave-assisted synthesis are reducing reliance on harsh reagents, aligning with sustainability goals without compromising yield.

In academic and industrial settings, CAS 854382-33-5 is frequently cited in patents for kinase inhibitors and enzyme modulators. Its utility in fragment-based drug design (FBDD) is another hot topic, with searches for "small fragments for lead optimization" rising. The compound’s molecular weight (291.53 g/mol) and logP values are critical for ADMET predictions, a key step in preclinical development.

To summarize, O-(2-Iodobenzyl)hydroxylamine hydrochloride (CAS 854382-33-5) bridges multiple disciplines, from organic synthesis to biopharmaceuticals. Its adaptability to emerging technologies like AI-aided molecular modeling ensures sustained demand. As research expands into neurodegenerative diseases and immuno-oncology, this compound’s role in next-generation therapeutics will likely grow, solidifying its place in the scientific toolkit.

• 5159-41-1((2-Iodophenyl)methanol)
• 126156-20-5((2-Iodo-4-methylphenyl)methanol)
• 62375-87-5(DIAZENE, (2-IODOPHENYL)METHOXY-, (E)-)
• 169786-59-8(BENZENEMETHANOL, 2,5-DIIODO-)
• 100959-88-4(Benzenemethanol, 2-iodo-3-methyl-)
• 827045-00-1(Benzenemethanol, 2,5-diiodo-4-methyl-)
• 1446093-00-0(Hydroxylamine, O-[(4-iodophenyl)methyl]-, hydrochloride (1:1))
• 1813531-27-9((2-iodo-1,4-phenylene)dimethanol)
• 915706-87-5(1,4-Benzenedimethanol, 2,5-diiodo-)
• 220991-50-4((2-iodo-5-methylphenyl)methanol)