• 1. Emerging investigator series: bacteriophages as nano engineering tools for quality monitoring and pathogen detection in water and wastewater
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• 2. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)
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• 3. Excellent peroxidase mimicking property of CuO/Pt nanocomposites and their application as an ascorbic acid sensor?
  Xinhuan Wang,Shuangfei Cai,Cui Qi Analyst, 2017,142, 2500-2506
• 4. Excimer and exciplex formation in a pair of bright phosphorescent isomers constructed from Cu3(pyrazolate)3 and Cu3I3 coordination luminophores?
  Shun-Ze Zhan,Mian Li,Xiao-Ping Zhou,Dan Li,Seik Weng Ng RSC Adv., 2011,1, 1457-1459
• 5. Emerging investigators
  Polym. Chem., 2015,6, 5501-5502

1-Benzyl-3-(Propan-2-yl)Piperazine

The compound 1-benzyl-3-(propan-2-yl)piperazine (CAS No. 851014-13-6) is a heterocyclic organic compound with a piperazine backbone. Piperazines are six-membered rings consisting of four carbon atoms and two nitrogen atoms, making them a class of azacyclohexanes. The specific structure of this compound includes a benzyl group attached to the first nitrogen atom and an isopropyl group attached to the third carbon atom of the piperazine ring. This unique substitution pattern gives the compound its distinct chemical properties and potential applications in various fields, including pharmaceuticals, agrochemicals, and materials science.

Recent studies have highlighted the importance of piperazine derivatives in drug discovery. The benzyl group in 1-benzyl-3-(propan-2-yl)piperazine contributes to the compound's lipophilicity, which is a critical factor in drug bioavailability. Additionally, the isopropyl group enhances the molecule's stability and may influence its interaction with biological targets. These properties make the compound a promising candidate for further exploration in medicinal chemistry.

In terms of synthesis, 1-benzyl-3-(propan-2-yl)piperazine can be prepared through various methods, including nucleophilic substitution and ring-closing reactions. One common approach involves the reaction of benzylamine with an appropriately substituted aldehyde or ketone, followed by cyclization to form the piperazine ring. The choice of synthetic pathway depends on the availability of starting materials and the desired purity of the final product.

From a structural perspective, the piperazine ring in 1-benzyl-3-(propan-2-yl)piperazine is highly flexible, allowing for diverse conformations that can interact with biological macromolecules such as proteins and enzymes. This flexibility is advantageous in drug design, as it can lead to improved binding affinities and selectivity for specific targets. Recent research has focused on modifying the substituents on the piperazine ring to optimize these interactions.

The benzyl group in this compound also plays a role in modulating its pharmacokinetic properties. For instance, it can influence absorption, distribution, metabolism, and excretion (ADME) profiles, which are critical factors in determining a drug's efficacy and safety. Studies have shown that benzyl-substituted piperazines exhibit favorable pharmacokinetic characteristics, making them attractive for further development.

In addition to its potential in pharmaceutical applications, 1-benzyl-3-(propan-2-yl)piperazine has shown promise in materials science. Its ability to form stable complexes with metal ions makes it a candidate for use in coordination polymers and metal organic frameworks (MOFs). These materials have applications in catalysis, gas storage, and sensing technologies.

Recent advancements in computational chemistry have enabled researchers to predict the behavior of 1-benzyl-3-(propan-2-yl)piperazine under various conditions. Molecular modeling studies have provided insights into its electronic structure, reactivity, and potential interactions with biological systems. These computational tools are invaluable for guiding experimental efforts and accelerating drug discovery processes.

In conclusion, 1-benzyl-3-(propan-2-yli)piperazine (CAS No. 851014777) is a versatile compound with significant potential across multiple disciplines. Its unique structure, combined with recent advances in chemical research, positions it as a valuable tool for developing innovative solutions in medicine and materials science.

• 444892-03-9((S)-1-Benzyl-3-Isobutylpiperazine Hydrochloride Salt)
• 1339673-80-1(1-Benzyl-5-ethyl-2,2-dimethylpiperazine)
• 1431978-13-0(1-Benzyl-5-isopropyl-2,2-dimethylpiperazine)
• 681484-76-4(Piperazine, 3-[(1S)-1-methylpropyl]-1-(phenylmethyl)-, (3S)-)
• 260254-74-8((2R,5S)-1-Benzyl-5-isopropyl-2-methylpiperazine)
• 324748-62-1((3S)-1-benzyl-3-(propan-2-yl)piperazine)
• 78551-90-3(1-BENZYL-2(S)-ISOBUTYL-PIPERAZINE)
• 1341158-71-1(1-Benzyl-5-ethyl-2,2,5-trimethylpiperazine)
• 1429171-94-7(1-Benzyl-5,5-diethyl-2,2-dimethylpiperazine)
• 674791-94-7( )