• 1. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
  ChangjieLiu,PengLiu,XiaofengWang,XiaoqiangLi,JuskeHorita
• 2. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526
• 3. Dissolved oxygen sensor based on fluorescence quenching of oxygen-sensitive ruthenium complexes immobilized in sol–gel-derived porous silica coatings
  Analyst, 1996,121, 785-788
• 4. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
  Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932
• 5. Distinct impact of glycation towards the aggregation and toxicity of murine and human amyloid-β?
  Eunju Nam,Jiyeon Han,Sunhee Choi,Mi Hee Lim Chem. Commun., 2021,57, 7637-7640

• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers Aminophenyl ethers

2-Ethoxy-4-fluoroaniline, Hydrochloride (CAS No. 850568-36-4): An Overview of Its Properties and Applications

2-Ethoxy-4-fluoroaniline, hydrochloride (CAS No. 850568-36-4) is a versatile organic compound that has gained significant attention in the fields of pharmaceutical research and chemical synthesis. This compound is a derivative of aniline, characterized by the presence of an ethoxy group and a fluorine atom, which confer unique chemical and biological properties. The hydrochloride salt form enhances its solubility and stability, making it a valuable intermediate in various synthetic processes.

The molecular structure of 2-Ethoxy-4-fluoroaniline, hydrochloride is represented by the formula C₉H₁₁ClFN₂. The ethoxy group (OCH₂CH₃) and the fluorine atom (F) are strategically positioned on the aromatic ring, which significantly influences its reactivity and functional properties. The presence of these substituents can modulate the electronic properties of the molecule, making it a useful building block for the synthesis of more complex compounds.

In pharmaceutical research, 2-Ethoxy-4-fluoroaniline, hydrochloride has been explored for its potential in drug discovery and development. Recent studies have highlighted its role as a precursor in the synthesis of novel therapeutic agents. For instance, a study published in the Journal of Medicinal Chemistry demonstrated that derivatives of this compound exhibit promising anti-inflammatory and analgesic properties. The researchers found that the ethoxy and fluorine substituents play a crucial role in enhancing the bioavailability and efficacy of the final drug candidates.

The solubility and stability of 2-Ethoxy-4-fluoroaniline, hydrochloride make it particularly suitable for use in aqueous solutions, which is advantageous for both laboratory-scale experiments and industrial-scale production. Its hydrochloride form ensures that it remains stable under a wide range of pH conditions, reducing the risk of degradation during storage and handling. This property is particularly important in pharmaceutical formulations where maintaining the integrity of active ingredients is critical.

In addition to its applications in pharmaceuticals, 2-Ethoxy-4-fluoroaniline, hydrochloride has found use in other areas of chemical research. For example, it serves as an intermediate in the synthesis of dyes and pigments, where its unique electronic properties contribute to color stability and intensity. A study published in the Dyes and Pigments journal reported that derivatives of this compound exhibit excellent lightfastness and colorfastness, making them suitable for use in high-performance coatings and textiles.

The environmental impact of chemical compounds is an increasingly important consideration in their development and application. Research into the environmental fate and toxicity of 2-Ethoxy-4-fluoroaniline, hydrochloride has shown that it degrades readily under natural conditions, minimizing its potential for long-term environmental accumulation. This characteristic aligns with the growing emphasis on sustainable chemistry practices and green chemistry principles.

Safety is another critical aspect when handling chemical compounds like 2-Ethoxy-4-fluoroaniline, hydrochloride. While it is not classified as a hazardous material or controlled substance, proper safety protocols should be followed to ensure safe handling and storage. This includes using appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coats to prevent skin contact and inhalation. Additionally, it should be stored in a well-ventilated area away from incompatible materials to minimize the risk of chemical reactions or accidents.

In conclusion, 2-Ethoxy-4-fluoroaniline, hydrochloride (CAS No. 850568-36-4) is a multifaceted compound with significant potential in various fields of chemistry and pharmaceutical research. Its unique molecular structure confers valuable properties that make it an essential intermediate in synthetic processes. Ongoing research continues to uncover new applications for this compound, further highlighting its importance in advancing scientific knowledge and technological innovation.

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