Cas no 847502-88-9 (2,4-Difluoro-3-methylbenzaldehyde)
2,4-Difluoro-3-methylbenzaldehyde Chemical and Physical Properties
Names and Identifiers
-
- 2,4-Difluoro-3-methylbenzaldehyde
- Benzaldehyde, 2,4-difluoro-3-methyl-
- PubChem17004
- KSC495S7L
- MPOSIFXAXWZQED-UHFFFAOYSA-N
- 2,4-difluoro-3-methyl-benzaldehyde
- FCH921526
- CL8245
- AM61656
- ST2415796
- AX8066837
- AB0064173
- Z5177
- 2,4-Difluoro-3-methylbenzaldehyde (ACI)
- MFCD07777152
- J-507201
- AKOS005255017
- DTXSID90478299
- CS-0153671
- 847502-88-9
- DS-2080
- Z1201624179
- DB-005859
- SCHEMBL584614
- EN300-6768764
-
- MDL： MFCD07777152
- Inchi： 1S/C8H6F2O/c1-5-7(9)3-2-6(4-11)8(5)10/h2-4H,1H3
- InChI Key： MPOSIFXAXWZQED-UHFFFAOYSA-N
- SMILES： O=CC1C(F)=C(C)C(F)=CC=1
Computed Properties
- Exact Mass: 156.03900
- Monoisotopic Mass: 156.03867113g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 3
- Heavy Atom Count: 11
- Rotatable Bond Count: 1
- Complexity: 149
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 17.1
- Surface Charge: 0
- Tautomer Count: nothing
- XLogP3: 1.9
Experimental Properties
- Density: 1.241
- Boiling Point: 198℃
- Flash Point: 74℃
- Refractive Index: 1.513
- PSA: 17.07000
- LogP: 2.08570
2,4-Difluoro-3-methylbenzaldehyde Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | B-UL969-200mg |
2,4-Difluoro-3-methylbenzaldehyde |
847502-88-9 | 97% | 200mg |
149.0CNY | 2021-07-12 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | B-UL969-1g |
2,4-Difluoro-3-methylbenzaldehyde |
847502-88-9 | 97% | 1g |
519.0CNY | 2021-07-12 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | B-UL969-5g |
2,4-Difluoro-3-methylbenzaldehyde |
847502-88-9 | 97% | 5g |
1490.0CNY | 2021-07-12 | |
| TRC | D445738-250mg |
2,4-Difluoro-3-methylbenzaldehyde |
847502-88-9 | 250mg |
$64.00 | 2023-05-18 | ||
| TRC | D445738-1g |
2,4-Difluoro-3-methylbenzaldehyde |
847502-88-9 | 1g |
$ 90.00 | 2022-06-05 | ||
| TRC | D445738-50mg |
2,4-Difluoro-3-methylbenzaldehyde |
847502-88-9 | 50mg |
45.00 | 2021-08-14 | ||
| TRC | D445738-100mg |
2,4-Difluoro-3-methylbenzaldehyde |
847502-88-9 | 100mg |
60.00 | 2021-08-14 | ||
| TRC | D445738-500mg |
2,4-Difluoro-3-methylbenzaldehyde |
847502-88-9 | 500mg |
$81.00 | 2023-05-18 | ||
| Fluorochem | 033814-1g |
2,4-Difluoro-3-methylbenzaldehyde |
847502-88-9 | 95% | 1g |
￡42.00 | 2022-03-01 | |
| Fluorochem | 033814-5g |
2,4-Difluoro-3-methylbenzaldehyde |
847502-88-9 | 95% | 5g |
￡140.00 | 2022-03-01 |
2,4-Difluoro-3-methylbenzaldehyde Suppliers
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2,4-Difluoro-3-methylbenzaldehyde Related Literature
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Xixi Li,Nanwei Zhu,Ruohan Li,Qinpu Zhang Anal. Methods, 2020,12, 3376-3381
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Robert J. Meagher,Anson V. Hatch,Ronald F. Renzi,Anup K. Singh Lab Chip, 2008,8, 2046-2053
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Kui Wu,Zhihua Yang,Shilie Pan Dalton Trans., 2015,44, 19856-19864
Additional information on 2,4-Difluoro-3-methylbenzaldehyde
Recent Advances in the Application of 2,4-Difluoro-3-methylbenzaldehyde (CAS: 847502-88-9) in Chemical Biology and Pharmaceutical Research
2,4-Difluoro-3-methylbenzaldehyde (CAS: 847502-88-9) is a fluorinated aromatic aldehyde that has garnered significant attention in recent years due to its versatile applications in chemical biology and pharmaceutical research. This compound serves as a crucial intermediate in the synthesis of various bioactive molecules, including potential drug candidates and agrochemicals. The unique electronic and steric properties imparted by the fluorine atoms and methyl group make it a valuable building block for designing molecules with enhanced pharmacological profiles.
Recent studies have highlighted the role of 2,4-Difluoro-3-methylbenzaldehyde in the development of novel kinase inhibitors and antimicrobial agents. For instance, a 2023 study published in the Journal of Medicinal Chemistry demonstrated its utility in the synthesis of selective JAK2 inhibitors, which show promise for treating myeloproliferative disorders. The fluorine atoms in the compound were found to significantly improve binding affinity and metabolic stability of the resulting inhibitors.
In the field of material science, researchers have explored the use of 2,4-Difluoro-3-methylbenzaldehyde as a precursor for liquid crystal materials. A 2024 publication in Advanced Materials reported that derivatives of this compound exhibit excellent thermal stability and mesomorphic properties, making them suitable for display technologies. The study also noted that the specific substitution pattern (2,4-difluoro-3-methyl) contributes to reduced rotational viscosity in the liquid crystal phase.
From a synthetic chemistry perspective, several innovative methodologies have been developed for the efficient production and further functionalization of 2,4-Difluoro-3-methylbenzaldehyde. A recent breakthrough published in Organic Letters (2024) described a palladium-catalyzed carbonylative approach that allows for gram-scale synthesis with excellent yield and purity. This advancement addresses previous challenges in large-scale production of this valuable intermediate.
The safety profile and environmental impact of 2,4-Difluoro-3-methylbenzaldehyde have also been subjects of recent investigation. Regulatory studies conducted in 2023 indicate that while the compound requires careful handling due to its aldehyde functionality, it demonstrates favorable biodegradation characteristics compared to non-fluorinated analogs. These findings support its continued use in pharmaceutical manufacturing with appropriate safety measures.
Looking forward, the unique properties of 2,4-Difluoro-3-methylbenzaldehyde position it as a key player in the development of next-generation therapeutics and functional materials. Ongoing research is exploring its potential in PROTAC (proteolysis targeting chimera) technology and as a building block for covalent inhibitors. The compound's versatility and the recent methodological advances in its utilization suggest it will remain an important tool in chemical biology and drug discovery efforts.
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