• 1. An automatic determination of thoria in thoria-urania mixtures
  Analyst, 1966,91, 208-210
• 2. An integrated cathode and solid electrolyte via in situ polymerization with significantly reduced interface resistance?
  Jialiang Yuan,Ran Dong,Yuan Li,Yang Liu,Zhuo Zheng,Yuxia Liu,Yan Sun,Benhe Zhong,Zhenguo Wu,Xiaodong Guo Chem. Commun., 2021,57, 13004-13007
• 3. An asymmetric supercapacitor based on controllable WO3 nanorod bundle and alfalfa-derived porous carbon?
  Kanjun Sun,Fengting Hua,Shuzhen Cui,Yanrong Zhu,Hui Peng,Guofu Ma RSC Adv., 2021,11, 37631-37642
• 4. An artificial blood vessel implanted three-dimensional microsystem for modeling transvascular migration of tumor cells?
  Xue-Ying Wang,Ying Pei,Min Xie,Zi-He Jin,Ya-Shi Xiao,Yang Wang,Li-Na Zhang,Yan Li,Wei-Hua Huang Lab Chip, 2015,15, 1178-1187
• 5. An antioxidative galactomannan extracted from Chinese Sesbania cannabina enhances immune activation of macrophage cells?
  Chongyang Zhu,Xiaojia Bian,Xin Jia,Ning Tang,Yongqiang Cheng Food Funct., 2020,11, 10635-10644

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Phenylpyridines

Introduction to 6-methyl-5-phenylpyridin-2-amine (CAS No. 84596-30-5) and Its Applications in Modern Chemical Research

6-methyl-5-phenylpyridin-2-amine, identified by the Chemical Abstracts Service Number (CAS No.) 84596-30-5, is a significant heterocyclic compound that has garnered considerable attention in the field of pharmaceutical chemistry and medicinal research. This compound belongs to the pyridine family, a class of nitrogen-containing aromatic heterocycles that are widely recognized for their diverse biological activities and industrial applications. The structural features of 6-methyl-5-phenylpyridin-2-amine, characterized by the presence of a methyl group at the 6-position and a phenyl ring at the 5-position, contribute to its unique chemical properties and potential therapeutic benefits.

The pyridine core of 6-methyl-5-phenylpyridin-2-amine is a versatile scaffold that has been extensively explored in drug discovery due to its ability to interact with various biological targets. Pyridine derivatives are known to exhibit a broad spectrum of pharmacological effects, including antimicrobial, anti-inflammatory, and anticancer properties. In recent years, there has been a growing interest in developing novel pyridine-based compounds as lead candidates for therapeutic intervention. The amine functional group at the 2-position of this molecule further enhances its reactivity, making it a valuable intermediate in synthetic chemistry and drug design.

One of the most compelling aspects of 6-methyl-5-phenylpyridin-2-amine is its potential application in the development of targeted therapies. Recent studies have highlighted the importance of pyridine derivatives in modulating enzyme activity and receptor binding. For instance, modifications of the pyridine ring have been shown to improve binding affinity and selectivity towards specific biological targets, which is crucial for minimizing side effects and enhancing therapeutic efficacy. The structural flexibility of 6-methyl-5-phenylpyridin-2-amine allows for further derivatization, enabling researchers to fine-tune its pharmacological profile for specific applications.

In the realm of medicinal chemistry, 6-methyl-5-phenylpyridin-2-amine has been investigated as a precursor for more complex drug molecules. Its ability to serve as a building block for larger scaffolds has made it particularly useful in the synthesis of small-molecule inhibitors and agonists. For example, researchers have utilized this compound to develop novel agents that target kinases and other enzymes involved in cancer progression. The phenyl ring at the 5-position provides a hydrophobic anchor that can enhance membrane permeability, while the methyl group at the 6-position can influence electronic distribution and metabolic stability.

The synthesis of 6-methyl-5-phenylpyridin-2-amine typically involves multi-step organic reactions, often starting from readily available pyridine derivatives. Advances in synthetic methodologies have enabled more efficient and scalable production processes, making this compound more accessible for research purposes. Techniques such as palladium-catalyzed cross-coupling reactions have been particularly useful in constructing the desired pyridine core structure with high precision. These advancements have not only improved yield but also reduced environmental impact, aligning with the growing emphasis on sustainable chemistry.

From a computational chemistry perspective, 6-methyl-5-phenylpyridin-2-amines has been subjected to extensive molecular modeling studies to understand its interactions with biological targets. Computer simulations have provided valuable insights into binding affinities, enzyme kinetics, and drug metabolism. These computational approaches complement experimental data and have accelerated the discovery process by allowing virtual screening of potential drug candidates before costly laboratory synthesis. The integration of machine learning algorithms has further enhanced predictive capabilities, enabling researchers to identify optimal modifications for improved pharmacological activity.

The pharmacological profile of 6-methyl--phenylpyridin--2--amine continues to be explored in preclinical studies aimed at identifying new therapeutic applications. Initial findings suggest that this compound may exhibit promising effects in treating neurological disorders due to its ability to cross the blood-brain barrier and interact with central nervous system receptors. Additionally, its potential anti-inflammatory properties have been observed in cell-based assays, indicating its utility in developing treatments for chronic inflammatory conditions such as arthritis and autoimmune diseases.

In conclusion,6-methyl--phenylpyridin--2--amine (CAS No. 84596--30--5) represents a significant advancement in chemical research with far-reaching implications for pharmaceutical development. Its unique structural features make it a valuable tool for designing novel therapeutics targeting various diseases. As research progresses,this compound is expected to play an increasingly important role in both academic investigations and industrial applications,driving innovation across multiple disciplines within chemical biology and medicinal chemistry.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)