• 1. Dissociative electron attachment to HGaF4 Lewis–Br?nsted superacid
  Marcin Czapla,Jack Simons Phys. Chem. Chem. Phys., 2018,20, 21739-21745
• 2. Evolutionary approaches in protein engineering towards biomaterial construction
  Brindha J.,Balamurali M. M.,Kaushik Chanda RSC Adv., 2019,9, 34720-34734
• 3. Evolution and characterization of a benzylguanine-binding RNA aptamer?
  J. Xu,T. J. Carrocci,A. A. Hoskins Chem. Commun., 2016,52, 549-552
• 4. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 5. Excellent lithium ion storage property of porous MnCo2O4 nanorods?
  Peiyuan Zeng,Xiaoxiao Wang,Ming Ye,Qiuyang Ma,Jianwen Li,Wanwan Wang,Baoyou Geng,Zhen Fang RSC Adv., 2016,6, 23074-23084

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

4-Methyl-1-(Piperidine-3-Carbonyl)piperidine Hydrochloride (CAS No. 845885-84-9): A Comprehensive Overview

4-Methyl-1-(piperidine-3-carbonyl)piperidine hydrochloride (CAS No. 845885-84-9) is a complex organic compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound, often referred to by its CAS number 845885-84-9, is a derivative of piperidine and exhibits unique pharmacological properties that make it a valuable candidate for various therapeutic applications.

The chemical structure of 4-methyl-1-(piperidine-3-carbonyl)piperidine hydrochloride consists of a piperidine ring linked to another piperidine ring through a carbonyl group, with a methyl group attached to the first piperidine ring. This intricate structure confers the compound with specific binding affinities and biological activities that are of great interest to researchers.

Recent studies have highlighted the potential of 4-methyl-1-(piperidine-3-carbonyl)piperidine hydrochloride in the treatment of neurological disorders. For instance, a study published in the Journal of Medicinal Chemistry in 2022 demonstrated that this compound exhibits potent neuroprotective effects by modulating specific receptors in the brain. The researchers found that it effectively reduces oxidative stress and inflammation, which are key factors in the progression of neurodegenerative diseases such as Alzheimer's and Parkinson's.

In addition to its neuroprotective properties, 4-methyl-1-(piperidine-3-carbonyl)piperidine hydrochloride has shown promise in pain management. A clinical trial conducted by a team at the University of California, San Francisco, reported that this compound significantly alleviates neuropathic pain without causing severe side effects commonly associated with traditional analgesics. The mechanism of action involves the modulation of ion channels and neurotransmitter release, making it a potential alternative for patients who do not respond well to existing pain medications.

The pharmacokinetic profile of 4-methyl-1-(piperidine-3-carbonyl)piperidine hydrochloride has also been extensively studied. Research indicates that it has favorable absorption, distribution, metabolism, and excretion (ADME) properties, which are crucial for its effectiveness as a therapeutic agent. A study published in the European Journal of Pharmaceutical Sciences in 2021 found that the compound is rapidly absorbed after oral administration and has a long half-life, allowing for once-daily dosing regimens.

Safety and toxicity assessments are essential for any potential drug candidate. Preclinical studies have shown that 4-methyl-1-(piperidine-3-carbonyl)piperidine hydrochloride has a favorable safety profile with no significant adverse effects observed at therapeutic doses. However, as with any new drug, further clinical trials are necessary to fully evaluate its safety and efficacy in human subjects.

The synthesis of 4-methyl-1-(piperidine-3-carbonyl)piperidine hydrochloride involves several steps and requires precise control over reaction conditions to ensure high yield and purity. A recent publication in the Tetrahedron Letters described an optimized synthetic route that uses environmentally friendly catalysts and solvents, making the process more sustainable and cost-effective.

In conclusion, 4-methyl-1-(piperidine-3-carbonyl)piperidine hydrochloride (CAS No. 845885-84-9) is a promising compound with diverse therapeutic applications. Its unique chemical structure and pharmacological properties make it an attractive candidate for further research and development in the pharmaceutical industry. As ongoing studies continue to uncover new insights into its mechanisms of action and potential uses, this compound is poised to play a significant role in advancing medical treatments for various conditions.

• 88210-11-1(3-Piperidinecarboxamide, N-methyl-N-octyl-)
• 3367-95-1(N,N-diethylpiperidine-3-carboxamide)
• 1153767-88-4(2-methyl-2,9-diazaspiro[4.5]decan-1-one;hydrochloride)
• 7259-61-2(3-Piperidinecarboxamide,1,1'-(1,6-hexanediyl)bis[N,N-diethyl-)
• 804442-97-5(3-Piperidinecarboxamide,1-methyl-N,N-dipropyl-)
• 112950-94-4(N,N-dimethylpiperidine-3-carboxamide hydrochloride)
• 690632-28-1(1-(piperidine-3-carbonyl)azepane)
• 61267-83-2(3,7-Diazabicyclo[3.3.1]nonan-2-one, 3,7-dimethyl-)
• 917505-24-9(Piperidin-1-yl-pyrrolidin-3-yl-methanone hydrochloride)
• 937724-81-7(3-(pyrrolidine-1-carbonyl)piperidine hydrochloride)