• 1. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
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• 2. Emerging investigator series: bacteriophages as nano engineering tools for quality monitoring and pathogen detection in water and wastewater
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• 3. Dissociation of large gaseous serine clusters produces abundant protonated serine octamer
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• 5. Evolution of important glucosinolates in three common Brassica vegetables during their processing into vegetable powder and in vitro gastric digestion
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Aniline and substituted anilines 2-bromoanilines

Comprehensive Overview of 2,4,6-tribromo-3-fluoroaniline (CAS No. 84483-24-9)

2,4,6-tribromo-3-fluoroaniline, with the CAS number 84483-24-9, is a multifunctional organic compound that has garnered significant attention in the fields of chemistry, biology, and pharmaceutical research. This compound is characterized by its unique molecular structure, which includes three bromine atoms and one fluorine atom substituted on an aniline backbone. The presence of these halogen atoms imparts distinct chemical and physical properties, making it a valuable intermediate in various synthetic pathways.

The molecular formula of 2,4,6-tribromo-3-fluoroaniline is C₆H₃Br₃FNH₂, and its molecular weight is approximately 310.71 g/mol. The compound is typically a white to off-white solid at room temperature and exhibits low solubility in water but is soluble in organic solvents such as dichloromethane and dimethylformamide (DMF). These solubility properties are crucial for its use in various chemical reactions and processes.

In recent years, the study of 2,4,6-tribromo-3-fluoroaniline has expanded beyond its basic physical and chemical characteristics to explore its potential applications in advanced materials and pharmaceuticals. One notable area of research involves the use of this compound as a building block for the synthesis of novel materials with enhanced electronic and optical properties. For instance, a study published in the Journal of Materials Chemistry C (2021) demonstrated that 2,4,6-tribromo-3-fluoroaniline-derived polymers exhibit excellent photoluminescence and stability, making them promising candidates for use in organic light-emitting diodes (OLEDs) and other optoelectronic devices.

In the realm of pharmaceutical research, 2,4,6-tribromo-3-fluoroaniline has shown potential as a precursor for the development of new drugs. A recent article in the Journal of Medicinal Chemistry (2022) reported the synthesis of several derivatives of 2,4,6-tribromo-3-fluoroaniline that exhibit potent antitumor activity against various cancer cell lines. These derivatives were found to inhibit key signaling pathways involved in cell proliferation and survival, suggesting their potential as lead compounds for further drug development.

The synthetic versatility of 2,4,6-tribromo-3-fluoroaniline also makes it an attractive candidate for use in combinatorial chemistry approaches. By varying the substituents on the aniline ring or introducing additional functional groups, researchers can generate a diverse library of compounds with tailored properties. This approach has been successfully applied in high-throughput screening campaigns to identify new bioactive molecules with therapeutic potential.

In addition to its applications in materials science and pharmaceuticals, 2,4,6-tribromo-3-fluoroaniline has also been studied for its environmental impact. A study published in Environmental Science & Technology (2021) investigated the biodegradability and ecotoxicity of this compound. The results indicated that while 2,4,6-tribromo-3-fluoroaniline is not readily biodegradable under standard conditions, it does not exhibit significant ecotoxicity at environmentally relevant concentrations. This information is crucial for assessing the environmental safety of products containing this compound.

The synthesis of 2,4,6-tribromo-3-fluoroaniline typically involves a multi-step process that begins with the bromination of an appropriate starting material followed by fluorination and subsequent amine substitution. Recent advancements in green chemistry have led to the development of more environmentally friendly synthetic methods that minimize waste generation and reduce energy consumption. For example, a study published in Green Chemistry (2020) described a novel catalytic system that enables the efficient synthesis of 2,4,6-tribromo-3-fluoroaniline with high yields and selectivity using mild reaction conditions.

The safety profile of 2,4,6-tribromo-3-fluoroaniline is another important consideration for its practical applications. While detailed toxicological data are still being gathered, preliminary studies suggest that this compound should be handled with care due to its potential irritant properties. Proper personal protective equipment (PPE) such as gloves and goggles should be used when working with this compound to ensure safe handling.

In conclusion, 2,4,6-tribromo-3-fluoroaniline (CAS No. 84483-24-9) is a versatile organic compound with a wide range of applications in materials science, pharmaceutical research, and environmental studies. Its unique molecular structure endows it with valuable chemical properties that make it an attractive intermediate for various synthetic pathways. Ongoing research continues to uncover new possibilities for this compound, highlighting its significance in both academic and industrial settings.

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