• 1. Fe3O4/Au/Fe3O4 nanoflowers exhibiting tunable saturation magnetization and enhanced bioconjugation
  Feng Shi,Kunping Yan,Mingli Peng,Xiao Cheng,Yanling Luo,Xuemei Chen,V. A. L. Roy,Zuankai Wang Nanoscale, 2012,4, 747-751
• 2. Evidence that the availability of an allylic hydrogen governs the regioselectivity of the Wacker oxidation
  Matthew J. Gaunt,Jinquan Yu,Jonathan B. Spencer Chem. Commun., 2001, 1844-1845
• 3. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526
• 4. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 5. Fast-Track to Research Data Management in Experimental Material Science-Setting the Ground for Research Group Level Materials Digitalization.
  LarsBanko,AlfredLudwig

Exploring Cytidine,3'-azido-2',3'-dideoxy- (CAS No. 84472-89-9): A Key Nucleoside Analogue in Biomedical Research

In the rapidly evolving field of nucleoside chemistry, Cytidine,3'-azido-2',3'-dideoxy- (CAS No. 84472-89-9) has emerged as a compound of significant interest. This modified nucleoside, often referred to as 3'-azido-2',3'-dideoxycytidine, plays a crucial role in antiviral research and drug development. Its unique structure, featuring an azido group at the 3' position and the absence of hydroxyl groups at both 2' and 3' positions, makes it a valuable tool for scientists exploring novel therapeutic strategies.

The growing demand for nucleoside analogues in pharmaceutical research has put Cytidine,3'-azido-2',3'-dideoxy- in the spotlight. Researchers are particularly interested in its potential applications in studying viral replication mechanisms and developing antiviral agents. With the recent global focus on emerging viral infections, compounds like this are receiving increased attention from both academic institutions and pharmaceutical companies.

From a chemical perspective, Cytidine,3'-azido-2',3'-dideoxy- demonstrates several noteworthy characteristics. The azido modification at the 3' position introduces unique reactivity patterns, while the dideoxy structure affects its interaction with various enzymes. These properties make it particularly useful in mechanistic studies of nucleic acid metabolism and as a potential building block for modified oligonucleotides with specialized functions.

The synthesis and application of 3'-azido-2',3'-dideoxynucleosides have become important topics in medicinal chemistry. Many researchers are investigating how modifications like those in Cytidine,3'-azido-2',3'-dideoxy- can be leveraged to create compounds with improved pharmacological profiles. Current studies focus on optimizing the bioavailability and metabolic stability of such analogues, which are critical factors in drug development.

In the context of biochemical research tools, Cytidine,3'-azido-2',3'-dideoxy- serves multiple purposes. It's frequently used as a chain terminator in nucleic acid synthesis studies, helping scientists understand the intricacies of DNA and RNA polymerization. Additionally, its azido group provides a convenient handle for various bioconjugation techniques, making it valuable in probe development and labeling applications.

The market for specialized nucleoside derivatives like Cytidine,3'-azido-2',3'-dideoxy- has seen steady growth in recent years. Pharmaceutical companies and research institutions are increasingly seeking high-quality, well-characterized compounds for their drug discovery programs. This demand has led to improvements in synthetic methodologies and analytical techniques for producing and characterizing such modified nucleosides.

Quality control is particularly important for Cytidine,3'-azido-2',3'-dideoxy- and similar compounds. Researchers require materials with high chemical purity and well-documented spectroscopic characteristics for their experiments. Advanced analytical methods including HPLC, mass spectrometry, and NMR spectroscopy are routinely employed to ensure the integrity of these sensitive compounds.

From a regulatory perspective, Cytidine,3'-azido-2',3'-dideoxy- is primarily used for research purposes and falls under standard laboratory chemical guidelines. Proper handling procedures should always be followed, particularly due to the presence of the azido functional group, which requires specific safety considerations during storage and use.

The future applications of Cytidine,3'-azido-2',3'-dideoxy- appear promising. As our understanding of nucleic acid biochemistry deepens and new therapeutic targets are identified, modified nucleosides like this will likely play increasingly important roles. Current research directions include exploring its potential in antisense technology, gene silencing, and as a component of novel diagnostic probes.

For researchers working with Cytidine,3'-azido-2',3'-dideoxy-, several practical considerations are worth noting. The compound's stability under various conditions, its solubility characteristics, and optimal storage conditions are all important factors that can affect experimental outcomes. Many laboratories are developing specialized protocols for handling and utilizing this modified cytidine derivative in their specific applications.

In conclusion, Cytidine,3'-azido-2',3'-dideoxy- (CAS No. 84472-89-9) represents an important tool in modern biochemical and pharmaceutical research. Its unique structural features and versatile applications make it valuable for studying nucleic acid metabolism, developing therapeutic agents, and advancing our understanding of molecular biology processes. As research in these areas continues to expand, the significance of well-characterized nucleoside analogues like this one will only grow.

• 130108-76-8(Cytidine,4'-azido-2'-deoxy-)
• 108895-45-0(Cytidine,3'-azido-2',3'-dideoxy-5-methyl-, monohydrochloride (9CI))
• 115913-78-5(Cytidine,3'-azido-2',3'-dideoxy-N-methyl- (9CI))
• 67013-98-3( )
• 478182-28-4(R-1479)
• 876708-03-1(RO-9187)
• 87190-79-2(AzddMeC)
• 114827-22-4(Cytidine, 2'-azido-2',3'-dideoxy-)
• 84472-90-2(3'-Amino-2',3'-dideoxycytidine)
• 51034-68-5(2'-Azido-2'-deoxycytidine)