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Comprehensive Overview of 4-Amino-1-methyl-cyclohexanol hydrochloride (CAS No. 837377-20-5): Properties, Applications, and Industry Insights

4-Amino-1-methyl-cyclohexanol hydrochloride (CAS No. 837377-20-5) is a specialized organic compound with a molecular formula of C₇H₁₆ClNO. This cyclohexanol derivative features a unique structural combination of an amino group and a methyl group, making it valuable in pharmaceutical and chemical research. The hydrochloride salt form enhances its solubility and stability, which is critical for laboratory and industrial applications. Researchers often refer to it by synonyms such as 1-methyl-4-aminocyclohexanol HCl or 4-AMCH hydrochloride, highlighting its functional groups and salt form.

In recent years, the demand for customized pharmaceutical intermediates like 4-Amino-1-methyl-cyclohexanol hydrochloride has surged due to advancements in drug discovery and small-molecule therapeutics. Its structural versatility allows it to serve as a building block for chiral synthesis and bioactive molecule design, aligning with trends in personalized medicine. Google Scholar and PubMed data reveal growing interest in cyclohexanol-based compounds for their potential in targeting neurological and metabolic pathways, though specific applications of this compound remain under proprietary development.

The synthesis of CAS 837377-20-5 typically involves catalytic hydrogenation or reductive amination of precursor ketones, followed by HCl salt formation. Analytical characterization via HPLC, NMR, and mass spectrometry confirms its high purity (>98%), a key concern for buyers on platforms like ChemSrc and Sigma-Aldrich. Environmental and safety assessments indicate compliance with standard laboratory handling protocols, though users frequently search for "4-Amino-1-methyl-cyclohexanol hydrochloride SDS" to ensure proper storage (2–8°C, desiccated) and avoid hygroscopic degradation.

From an SEO perspective, trending queries such as "buy 4-Amino-1-methyl-cyclohexanol hydrochloride" and "837377-20-5 supplier" reflect commercial interest, while academic searches focus on "mechanism of action of cyclohexanol derivatives." The compound’s role in green chemistry initiatives also garners attention, as industries seek sustainable alternatives to traditional solvents. Notably, its low ecotoxicity profile positions it favorably in regulatory discussions about benign by design chemicals.

Ongoing research explores the stereochemical implications of the methyl group in 4-AMCH hydrochloride, particularly in asymmetric catalysis. Patent databases disclose its utility in pro-drug formulations and enzyme inhibition studies, though detailed mechanisms remain confidential. For quality assurance, vendors emphasize batch-specific COA (Certificate of Analysis) documentation, addressing buyer concerns about consistency—a top-ranked issue in B2B chemical procurement forums.

In summary, 4-Amino-1-methyl-cyclohexanol hydrochloride exemplifies the intersection of structural complexity and application diversity in modern fine chemicals. Its CAS No. 837377-20-5 serves as a critical identifier for researchers navigating the expanding landscape of functionalized cyclohexanes, while industry stakeholders monitor its potential in next-generation therapeutic adjuvants and material science innovations.

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