Cas no 82978-03-8 (4-O-tert-Butyldimethylsilyl Epi Lovastatin)
4-O-tert-Butyldimethylsilyl Epi Lovastatin is a chemically modified derivative of lovastatin, featuring a tert-butyldimethylsilyl (TBDMS) ether group at the 4-hydroxy position. This modification enhances the compound's stability and lipophilicity, making it a valuable intermediate in synthetic organic chemistry, particularly for the development of statin-based pharmaceuticals. The TBDMS protecting group improves selectivity during reactions and facilitates controlled deprotection under mild conditions. This derivative is primarily used in research settings to explore structure-activity relationships or to synthesize analogs with optimized pharmacokinetic properties. Its well-defined chemical properties and compatibility with standard laboratory protocols make it a reliable choice for medicinal chemistry applications.
82978-03-8 structure
Product Name:4-O-tert-Butyldimethylsilyl Epi Lovastatin
CAS No:82978-03-8
MF:C30H50O5Si
MW:518.800510883331
CID:1058773
PubChem ID:71314413
Update Time:2025-05-28
4-O-tert-Butyldimethylsilyl Epi Lovastatin Chemical and Physical Properties
Names and Identifiers
-
- 4-O-tert-Butyldimethylsilyl Epi Lovastatin
- [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-[tert-butyl(dimethyl)silyl]oxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2R)-2-methylbutanoate
- DTXSID40747265
- 82978-03-8
- (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-{[tert-Butyl(dimethyl)silyl]oxy}-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2R)-2-methylbutanoate
-
- Inchi： 1S/C30H50O5Si/c1-10-20(3)29(32)34-26-16-19(2)15-22-12-11-21(4)25(28(22)26)14-13-23-17-24(18-27(31)33-23)35-36(8,9)30(5,6)7/h11-12,15,19-21,23-26,28H,10,13-14,16-18H2,1-9H3/t19-,20+,21-,23+,24+,25-,26-,28-/m0/s1
- InChI Key： YZUJIMXHROAZNZ-LLDGAUDVSA-N
- SMILES： [Si](C)(C)(C(C)(C)C)O[C@H]1CC(=O)O[C@@H](C1)CC[C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC([C@H](C)CC)=O
Computed Properties
- Exact Mass: 518.34300
- Monoisotopic Mass: 518.34275123g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 5
- Heavy Atom Count: 36
- Rotatable Bond Count: 10
- Complexity: 854
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 8
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 61.8?2
Experimental Properties
- PSA: 61.83000
- LogP: 7.22500
4-O-tert-Butyldimethylsilyl Epi Lovastatin Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| TRC | B691355-1mg |
4-O-tert-Butyldimethylsilyl Epi Lovastatin |
82978-03-8 | 1mg |
$ 92.00 | 2023-04-18 | ||
| TRC | B691355-2mg |
4-O-tert-Butyldimethylsilyl Epi Lovastatin |
82978-03-8 | 2mg |
$ 173.00 | 2023-04-18 | ||
| TRC | B691355-2.5mg |
4-O-tert-Butyldimethylsilyl Epi Lovastatin |
82978-03-8 | 2.5mg |
$ 190.00 | 2023-04-18 | ||
| TRC | B691355-5mg |
4-O-tert-Butyldimethylsilyl Epi Lovastatin |
82978-03-8 | 5mg |
$ 345.00 | 2023-04-18 | ||
| TRC | B691355-10mg |
4-O-tert-Butyldimethylsilyl Epi Lovastatin |
82978-03-8 | 10mg |
$ 666.00 | 2023-04-18 | ||
| TRC | B691355-25mg |
4-O-tert-Butyldimethylsilyl Epi Lovastatin |
82978-03-8 | 25mg |
$ 1487.00 | 2023-04-18 | ||
| SHENG KE LU SI SHENG WU JI SHU | sc-396141-2.5mg |
4-O-tert-Butyldimethylsilyl Epi Lovastatin, |
82978-03-8 | 2.5mg |
￥2708.00 | 2023-09-05 | ||
| SHENG KE LU SI SHENG WU JI SHU | sc-396141-2.5 mg |
4-O-tert-Butyldimethylsilyl Epi Lovastatin, |
82978-03-8 | 2.5 mg |
￥2,708.00 | 2023-07-11 |
4-O-tert-Butyldimethylsilyl Epi Lovastatin Related Literature
-
Guang Xu,Wei Zhang,Ying Zhang,Xiaoxia Zhao,Ping Wen,Di Ma RSC Adv., 2018,8, 19353-19361
-
Tao Wang,Yangyang Liu,Yue Deng,Hongbo Fu,Jianmin Chen Environ. Sci.: Nano, 2018,5, 1821-1833
-
Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
-
Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126
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