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2-Methyl-2-phenylpropanamide (CAS No. 826-54-0): Properties, Applications, and Market Insights

2-Methyl-2-phenylpropanamide (CAS No. 826-54-0) is a specialized organic compound with a unique molecular structure that combines an amide functional group with a phenyl and methyl substituents. This white crystalline solid is gaining attention in pharmaceutical and chemical research due to its versatile applications. The compound's IUPAC name, 2-methyl-2-phenylpropanamide, reflects its precise chemical configuration, while alternative names like α,α-dimethylbenzeneacetamide may appear in older literature.

The molecular formula C₁₀H₁₃NO gives 2-methyl-2-phenylpropanamide a molecular weight of 163.22 g/mol. Its melting point typically ranges between 98-102°C, and it demonstrates moderate solubility in common organic solvents while being sparingly soluble in water. These physical-chemical properties make it particularly interesting for formulation scientists working on drug delivery systems. Recent studies have explored its potential as a building block in medicinal chemistry, especially for CNS-active compounds.

In pharmaceutical applications, 2-methyl-2-phenylpropanamide derivatives have shown promise as intermediates for anticonvulsant drugs. The structural similarity to known pharmacophores has led researchers to investigate its potential in developing new treatments for neurological disorders, a hot topic in medicinal chemistry. While not itself biologically active, the compound serves as a crucial scaffold that medicinal chemists can modify to create targeted therapies.

The synthesis of 2-methyl-2-phenylpropanamide (CAS 826-54-0) typically involves the reaction of 2-methyl-2-phenylpropanoic acid with ammonia or ammonium salts under controlled conditions. Process chemists have developed optimized routes that improve yield and purity while minimizing environmental impact—a key consideration in modern green chemistry initiatives. Recent patents highlight novel catalytic methods that reduce energy consumption during production.

Analytical characterization of 2-methyl-2-phenylpropanamide employs standard techniques including HPLC, GC-MS, and NMR spectroscopy. The compound shows distinctive peaks in ¹H NMR (δ 7.2-7.4 ppm for aromatic protons, δ 1.6 ppm for methyl groups) that aid in quality control. These analytical profiles are crucial for pharmaceutical manufacturers who must meet stringent regulatory requirements for chemical purity standards in drug development.

Beyond pharmaceuticals, 2-methyl-2-phenylpropanamide finds use in specialty chemical applications. Its stability and specific interactions make it valuable in polymer chemistry as a modifier or chain transfer agent. Some studies suggest potential applications in advanced material science, particularly in designing smart materials with responsive properties—an area of growing commercial interest.

The global market for 2-methyl-2-phenylpropanamide (826-54-0) reflects increasing demand from the pharmaceutical sector. Market analysts note steady growth at approximately 4-6% annually, driven by research into neurological drugs and specialty polymers. Major producers have established GMP-compliant manufacturing facilities to serve regulated markets, while smaller suppliers cater to research institutions.

Safety considerations for handling 2-methyl-2-phenylpropanamide follow standard laboratory protocols for organic compounds. While not classified as hazardous under current regulations, proper PPE including gloves and eye protection is recommended. The compound's environmental fate has been studied, showing moderate biodegradability under aerobic conditions—a factor increasingly important to sustainability-focused buyers.

Recent scientific literature highlights novel research directions for 2-methyl-2-phenylpropanamide derivatives. A 2023 study published in the European Journal of Medicinal Chemistry demonstrated its utility in creating dual-action compounds targeting both pain and inflammation. Such developments align with current drug discovery trends toward multifunctional therapeutics, making this compound particularly relevant to modern pharmaceutical research.

For researchers sourcing 2-methyl-2-phenylpropanamide (CAS 826-54-0), quality specifications typically require ≥98% purity by HPLC, with strict limits on residual solvents and heavy metals. Leading suppliers provide comprehensive analytical documentation including certificates of analysis and stability data. The compound is generally stable at room temperature when stored properly in airtight containers protected from light and moisture.

The future outlook for 2-methyl-2-phenylpropanamide appears promising as new applications emerge in material science and drug development. With increasing interest in structure-activity relationships and molecular design, this compound's unique structural features continue to attract research attention. Ongoing studies exploring its potential in agrochemicals and specialty coatings may further expand its commercial significance in coming years.

• 103-81-1(2-Phenylacetamide)
• 4695-13-0(2,2-Diphenylacetamide)
• 13490-74-9((2S)-2-phenylpropanamide)
• 10255-95-5(2-Phenylmalonamide)
• 6212-86-8(Benzeneacetamide,4-methyl-)
• 14182-57-1((2R)-2-phenylpropanamide)
• 59512-17-3(rac-Ibuprofen Amide)
• 1125-70-8(2-phenylpropanamide)
• 828-40-0(Benzeneacetamide, a-ethyl-a-methyl-)
• 127462-35-5(Benzeneacetamide, -alpha-,4-dimethyl-)