• 1. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
• 2. Exciplex emission from the mixed dimer of naphthalene and 2-cyanonaphthalene in a supersonic jet
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• 3. Excellent electrochemical performance of LiFe0.4Mn0.6PO4 microspheres produced using a double carbon coating process?
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• 4. Excitable dynamics in the bromate–sulfite–ferrocyanide reaction
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazanaphthalenes Cinnolines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazanaphthalenes Benzodiazines Cinnolines

Comprehensive Guide to 4-Chloro-3-iodocinnoline (CAS No. 82452-99-1): Properties, Applications, and Research Insights

4-Chloro-3-iodocinnoline (CAS No. 82452-99-1) is a halogenated cinnoline derivative that has garnered significant attention in pharmaceutical and materials science research. This compound, characterized by its unique molecular structure combining chlorine and iodine substituents, serves as a versatile intermediate in organic synthesis. Its CAS number 82452-99-1 is frequently searched in chemical databases, reflecting its relevance in modern chemistry.

The growing interest in halogenated heterocycles like 4-Chloro-3-iodocinnoline aligns with current trends in drug discovery, where researchers prioritize compounds with tunable electronic properties. Recent publications highlight its potential in designing kinase inhibitors and fluorescence probes, addressing popular queries about "cinnoline applications in medicine" and "iodine-containing bioactive molecules." The compound's dual halogen functionality enables selective cross-coupling reactions, a topic frequently discussed in synthetic chemistry forums.

From a structural perspective, 4-Chloro-3-iodocinnoline exhibits remarkable stability under ambient conditions, making it suitable for diverse experimental protocols. Analytical studies using NMR spectroscopy and X-ray crystallography confirm its planar aromatic system with distinct bond polarization patterns. These features respond to common search terms like "cinnoline structural analysis" and "halogen bonding in heterocycles," which dominate academic search trends.

In material science applications, this compound has been explored for developing organic semiconductors due to its electron-deficient core. The iodine atom's heavy atom effect makes it valuable in phosphorescent material design, addressing industry demands for efficient OLED components. Such applications correlate with trending searches about "cinnoline-based electronic materials" and "heavy halogen functionalization."

Quality control protocols for CAS 82452-99-1 typically involve HPLC purity verification (>98%) and residual solvent analysis, meeting stringent requirements for research-grade chemicals. Storage recommendations (2-8°C under inert atmosphere) and handling precautions are frequently requested information, reflecting user concerns about compound stability.

The synthetic versatility of 4-Chloro-3-iodocinnoline enables its transformation into various derivatives through Sonogashira coupling, Buchwald-Hartwig amination, and other transition metal-catalyzed reactions. These transformations answer common technical queries about "modifying iodinated cinnolines" and "cross-coupling with chloro-iodo systems." Recent patent literature demonstrates its utility in creating EGFR inhibitors, connecting to popular oncology research topics.

Environmental and safety assessments of 82452-99-1 indicate proper waste disposal methods for halogenated compounds, addressing regulatory concerns in laboratory settings. The compound's structure-activity relationship studies frequently appear in medicinal chemistry publications, particularly regarding heterocyclic drug design principles that dominate current pharmaceutical research discussions.

Future research directions for 4-Chloro-3-iodocinnoline may explore its potential in photoredox catalysis and as a building block for covalent organic frameworks (COFs). These applications respond to emerging trends in sustainable chemistry and advanced materials, topics generating increasing search volume in scientific databases.

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